Core A: Administrative Core

核心A：行政核心

• 批准号: 10640137
• 负责人: MARY CUSHMAN
• 金额: $ 80.93万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640137
• 关键词: Accountability; Advisory Committees; American; Annual Reports; Attention; Award; Basic Science; Brain Diseases; Budgets; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Clinical; Clinical Investigator; Clinical Sciences; Collaborations; Communication; Communities; Core Facility; Data; Databases; Dementia; Development; Dimensions; Discipline; Disease; Education; Ensure; Equity; Faculty; Fostering; Foundations; Funding; Future; General Population; Goals; Grant; Health; Heart; Image; Impaired cognition; Infrastructure; Institution; Leadership; Medicine; Mentors; Mentorship; Microvascular Dysfunction; Molecular Epidemiology; Outcome; Pathogenesis; Persons; Phase; Physiology; Positioning Attribute; Program Development; Protocols documentation; Research; Research Design; Research Institute; Research Personnel; Resources; Science; Scientist; Services; Specimen; Strategic Planning; Stroke; Teacher Professional Development; Techniques; Underrepresented Minority; Universities; Vermont; Woman; Work; brain health; cardiovascular health; career; career development; cohort; college; cost; disability; experience; faculty mentor; improved; innovation; interest; man; member; multidisciplinary; neurovascular; next generation; operation; peer coaching; programs; prospective; recruit; research and development; success; symposium

Cardiovascular disease, stroke and cognitive impairment / dementia are leading causes of death and disability, and they arise from several common antecedents. The Vermont Center for Cardiovascular and Brain Health (VCCBH) COBRE at the University of Vermont (UVM) will address these diseases by supporting diverse scientists from multiple disciplines who will work together to understand the pathobiology and molecular epidemiology of these diseases. The Administrative Core (Core A), led by COBRE PIs Drs. Mary Cushman and Mark Nelson, will be the heart of the VCCBH. It will provide administrative infrastructure and resources that will produce the next generation of science leaders at UVM. Four junior faculty Project Directors (PDs) are central to our effort. Core A will be accountable for key functions necessary for PD success, for Cores, for engaging prospective PDs to replace the first cohort, and ultimately, for the future sustainability of the VCCBH. Core A will foster innovation by creating a culture of openness, diversity, and collaboration. The Core will administer an Interdisciplinary Strategic Mentoring Initiative to guide PDs to independent status (Aim 1). Multidisciplinary mentoring teams will include two Senior Mentors, a Peer Mentor at the “first independent step” career stage, and an experienced External Mentor. The Peer Mentor will benefit from this early opportunity to provide faculty mentoring. The Core will develop and employ a comprehensive Faculty Development Program (FDP) and Core facilities focused on PDs (Aim 2). The FDP will be highlighted by an institutionally supported Pilot Grant Award program that will provide 4 grants of $200,000 each to pairs of junior faculty with different research backgrounds. The capstone of the FDP will be an annual 2-day research symposium that will highlight PD research and development of new projects. The Core will supervise development of new Cores in “Study Design and Molecular Epidemiology” and “Customized Physiology and Imaging.” The Core will manage the VCCBH budget, and assist and educate the PDs in budget management (Aim 3). Core A will coordinate Internal and External Advisory Boards, develop outcome metrics, and provide semi-annual reports on these to PDs, mentor teams, and Advisory Boards (Aim 4). Finally, the Core will provide communication across the University and beyond on the Center's scientific expertise, Core resources and databases, and resources generated by the VCCBH (data, specimens, study protocols, new techniques, and research results) (Aim 5). A Communications Committee will include professionals from the Office of Communications of the Larner College of Medicine and the UVM Foundation in order to promote philanthropy. By completing the Specific Aims we will: (1) propel 4 early-career scientists to independence; (2) cultivate a pipeline of early career scientists to fill PD positions as original PDs achieve funding; (3) recruit 5 new junior faculty to UVM to enter our pipeline of prospective PDs; (4) promote collaboration amongst faculty and trainees working in cardiovascular and neurovascular research across the colleges of UVM.

心血管疾病、中风和损伤/痴呆是死亡和残疾的主要原因， 它们源于佛蒙特州心血管和大脑健康中心的几个共同背景。 (VCCBH) 佛蒙特大学 (UVM) 的 COBRE 将通过支持多种方式来应对这些疾病 来自多个学科的科学家将共同努力了解病理生物学和分子生物学 这些疾病的流行病学，由 COBRE PI 玛丽·库什曼 (Mary Cushman) 博士领导。 马克·尼尔森 (Mark Nelson) 将成为 VCCBH 的核心，它将提供行政基础设施和资源。 这将培养 UVM 的下一代科学领导者，四名初级教员项目总监 (PD) 是 核心 A 将负责 PD 成功所需的关键职能。 让潜在的 PD 来取代第一批，并最终实现 VCCBH 未来的可持续性。 Core A 将通过创造开放、多元化和协作的文化来促进创新。 管理跨学科战略指导计划，指导 PD 获得独立地位（目标 1）。 多学科指导团队将包括两名高级导师，以及“第一个独立步骤”的同行导师 职业阶段，经验丰富的外部导师将受益于这个早期机会。 核心将制定和采用全面的教师发展计划。 (FDP) 和侧重于 PD 的核心设施（目标 2） FDP 将通过机构支持来强调。 试点补助金奖励计划将为具有不同背景的初级教师提供 4 笔补助金，每人 20 万美元 FDP 的顶峰将是每年一次为期 2 天的研究研讨会。 强调新项目的 PD 研究和开发。核心将监督新核心的开发。 “研究设计和分子流行病学”和“定制生理学和影像学”。 VCCBH 预算，并协助和教育 PD 进行预算管理（目标 3）。 内部和外部顾问委员会制定成果指标，并提供有关这些指标的半年度报告 最后，核心将提供跨部门的沟通。 大学及其他机构关于该中心的科学专业知识、核心资源和数据库以及资源 由 VCCBH 生成（数据、样本、研究方案、新技术和研究结果）（目标 5）。 传播委员会将包括来自拉纳传播办公室的专业人员 医学院和 UVM 基金会通过完成具体项目来促进慈善事业。 我们的目标是：(1) 推动 4 名早期职业科学家走向独立；(2) 培养早期职业科学家的渠道； 当原来的 PD 获得资助时，科学家将填补 PD 职位；(3) 招募 5 名新的初级教员进入UVM； (4) 促进教师和实习生之间的合作 UVM 各学院的心血管和神经血管研究。