PS07-003, Minority HIV/AIDS Research Initiative (MARI)

PS07-003，少数群体艾滋病毒/艾滋病研究计划 (MARI)

• 批准号: 7685385
• 负责人: Emma J Brown
• 金额: $ 23.3万
• 依托单位: CHARM, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685385
• 关键词: PS07; 003; Minority; HIV; AIDS

DESCRIPTION (provided by applicant): The study proposed in this application addresses the second new strategy for HIV prevention under CDC's Advancing HIV Prevention (AHP) initiative; the implementation of new models for diagnosing HIV infections outside medical settings and one of the six research objectives of the RFA, Voluntary HIV testing and counseling of heterosexual Black and Hispanic males. The short-term study objective is to identify barriers and facilitators associated with HIV testing and disclosure of HIV+ test results-- black males18 - 64 who self- identify as heterosexual--determining whether these differ by relationship type (wife, regular outside female sexual partner, causal female sexual partner, male sexual partner) and to determine if providing HIV testing options will result in increase acceptability of HIV testing. The long-term objective is to develop an intervention to promote HIV testing and disclosure of HIV positive status to sexual partners that is cultural, gender, and region specific for rural/small city African American males who self-identify as heterosexual. The study design consists of four phases; Phase 1-Qualitative Descriptive focus groups (n=36) to inform the development of the survey items, Phase 2-Cross-sectional Instrument Developments and Testing (n=300) utilizing a mixed method approach of instruments administration and focus groups, Phase 3-Cross- sectional survey administration (n=3000) and randomized controlled trial at the individual level (n=300) comparing experimental condition with rapid HIV testing procedure (OraQuick Rapid HIV-1/2 Antibody or OraQuick Advance Rapid HIV-1/2 Antibody) via community outreach with the controlled condition/standard non-rapid OraSure or serological test, and Phase 4-Qualitative Descriptive process evaluation utilizing 12 focus groups (N=72, n=36 survey participants who did not participate in the randomized controlled trial and n=36 participants of the randomized controlled trial) to assess attitude toward HIV testing, perception of barriers to and facilitators of HIV testing, perception of assistance needed to improve HIV+ disclosure skills, and perception of strategies to improve HIV testing. The objective of this research has public health relevance to the Black community related to HIV. Three Healthy People 2010 objectives are addressed by this proposed research; 13-7 Increase the number of HIV- positive persons who know their serostatus, 3-13 Increase the proportion of HIV-infected adolescents and adults who receive testing, treatment, and prophylaxis consistent with current Public Health Service treatment guidelines, and 5-8 Reduce HIV infections in adolescent and young adult females aged 13 to 24 years that are associated with heterosexual contact. The objective of this research has public health relevance to the Black community related to HIV. Three Healthy People 2010 objectives are addressed by this proposed research: 13-7, Increase the number of HIV- positive persons who know their serostatus; 3-13, Increase the proportion of HIV-infected adolescents and adults who receive testing, treatment, and prophylaxis consistent with current Public Health Service treatment guidelines; and 5-8, Reduce HIV infections in adolescent and young adult females aged 13 to 24 years that are associated with heterosexual contact.

描述（由申请人提供）：本申请中提出的研究介绍了CDC预防艾滋病毒预防（AHP）倡议的第二种新的艾滋病毒预防策略；实施新模型，用于诊断医疗环境之外的艾滋病毒感染以及RFA的六个研究目标之一，异性恋黑人和西班牙裔男性的自愿艾滋病毒测试和咨询。短期研究的目标是确定与HIV测试和HIV+测试结果相关的障碍和促进因素 - 黑人男性18-64，他们自我识别为异性恋 - 确定这些因素是否会因关系类型而有所不同（妻子，妻子，常规的外在性伴侣，女性性伴侣，因果关系，导致女性性伴侣，男性性伴侣，男性性伴侣，男性性伴侣，男性性伴侣）并确定是否会导致HIV测试能力可接受HIV的能力。长期目标是制定一项干预措施，以促进艾滋病毒测试和披露艾滋病毒阳性地位的性伴侣，这些伴侣是文化，性别和针对自我认同为异性恋的农村/小城市非洲裔美国男性特有的。研究设计包括四个阶段。第1阶段质量描述焦点组（n = 36）为调查项目的发展提供信息，2阶段截面仪器的发展和测试（n = 300）使用仪器给药的混合方法和焦点组的混合方法，第3阶段分段调查管理（n = 3000）（n = 3000）（n = 3000）（n = 3000）以及在个人级别（niv = 300）的级别（n = 300）进行HIV HEIV（n = 300）的随机对照（n = 300）抗体或Oraquick通过社区宣传进行抗体或抗体快速HIV-1/2抗体），具有受控状态/标准的非比值或血清学检验，以及第4阶段的第4阶段质量描述过程评估，利用12个焦点组（n = 72，n = 36个调查参与者，他们都不参与随机对照的试验和n = 36的参与者，以评估36的参与者，并评估n = 36的参与者，以评估n = 36艾滋病毒测试的促进者，提高艾滋病毒+披露技能所需的援助感知以及改善艾滋病毒测试的策略的感知。这项研究的目的与与艾滋病毒有关的黑人社区的公共卫生相关。这项拟议的研究解决了三个健康的2010年目标。 13-7增加了了解其血统的艾滋病毒阳性人数，3-13增加了与当前公共卫生服务治疗指南一致的测试，治疗和预防的艾滋病毒感染的青少年和成年人的比例，而5-8减少了与13至24岁的成年女性相关的与HIRSOSES相关的年轻人的HIV感染。这项研究的目的与与艾滋病毒有关的黑人社区的公共卫生相关。这项拟议的研究解决了三个健康的2010年目标：13-7，增加了了解其血清的艾滋病毒阳性人数； 3-13，增加了与当前公共卫生服务治疗指南一致的测试，治疗和预防的艾滋病毒感染的青少年和成年人的比例；和5-8，减少与异性恋接触有关的13至24岁的青少年和年轻女性的HIV感染。