Defining Human Cortical Functional Areas Using Resting Functional Connectivity

使用静息功能连接定义人类皮质功能区域

• 批准号: 7588068
• 负责人: Alexander Li Cohen
• 金额: $ 2.79万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7588068
• 关键词: Aging; Area; Brain; Clinical; Collection; Development; Functional Imaging; Functional Magnetic Resonance Imaging; Generations; Human; Image Analysis; Individual; Label; Life; Location; Maps; Measures; Methods; Pattern; Population Study; Research; Rest; Signal Transduction; Study Subject; tool

DESCRIPTION (provided by applicant): The objective of this research is to use intrinsic ongoing fluctuations in human brain activity to delineate cortical functional areas in individuals. Defining functional areas in living humans is currently only possible for a small fraction of areas. As such, the generation of cortex-wide maps of functional areas for individuals would allow for more accurate and functionally meaningful distinctions to be utilized without relying on current stereotactic or functional localizer approaches. The current study will utilize spontaneous fluctuations in the resting state fMRI BOLD signal (rs-fcMRI). rs-fcMRI across expanses of cortex show strong localized differences in patterns of correlation strength. These localized differences will then be analyzed using a set of image analysis tools to explore the plausibility of using rs-fcMRI measures to aid in the definition of widespread functional area boundaries. In addition to providing better areal labeling within individuals, this method would allow us to directly examine the variability of area extent, location, and organization across subjects, which is currently extremely difficult, if not impossible, to do with functional imaging. If the full, or even a partial, collection of functional areas can be delineated and characterized across subjects, the study of anatomical and functional differences between groups, including developmental studies, studies of normal or abnormal aging, or clinical population studies will be greatly facilitated.

描述（由申请人提供）： 这项研究的目的是利用人脑活动中的内在持续波动来描述个体的皮质功能区域。目前，只有一小部分地区才有可能定义人类的功能区域。因此，在不依赖当前的立体定位或功能性位置方法的情况下，可以利用个人的功能区域的皮质范围图生成更准确且功能上有意义的区别。当前的研究将利用静止状态fMRI BOLD信号（RS-FCMRI）中的自发波动。跨皮质膨胀的RS-FCMRI在相关强度模式方面表现出很强的局部差异。然后，将使用一组图像分析工具对这些局部差异进行分析，以探讨使用RS-FCMRI测量方法的合理性，以帮助定义广泛的功能区域边界。除了在个人内部提供更好的面积标签外，此方法还可以直接检查跨受试者的区域，位置和组织的变异性，这对于功能成像而言目前极为困难，即使不是不可能。如果可以在受试者中划定和表征全部甚至部分功能区域的收集，那么将在包括发育研究，正常或异常衰老的研究中对解剖学和功能差异进行研究，或者将在很大程度上促进临床人群研究。