Database system for patient-based neuroscience research

基于患者的神经科学研究数据库系统

• 批准号: 7626027
• 负责人: DANIEL Y KIMBERG
• 金额: $ 29.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7626027
• 关键词: Address; Adopted; Agreement; Atlases; Atrophic; Behavioral; Brain; Brain Diseases; Brain imaging; Code; Cognitive; Collaborations; Data; Databases; Diffusion Magnetic Resonance Imaging; Disease; Electronics; Etiology; Exclusion; Functional Imaging; Future; Hand; Health Insurance Portability and Accountability Act; Hospitals; Human; Image; Individual; Informatics; Institution; Lesion; Location; Magnetic Resonance Imaging; Maps; Measures; Methods; Neurodegenerative Disorders; Neurologic; Neuropsychological Tests; Neurosciences Research; Ontology; Patients; Population; Privacy; Probability; Process; Qualifying; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Research Subjects; Research Support; Resolution; Resource Sharing; Resources; Risk; Security; System; Techniques; Testing; base; cognitive function; cost; data management; data sharing; database design; design; executive function; flexibility; improved; injured; interoperability; meetings; neuromechanism; portability; programs; relating to nervous system; software systems; stimulus processing; tool; white matter

Study of brain-injured patients has long been a critical method in understanding cognitive function in humans. However, methods and tools for managing data for patient-based studies - including demographic, behavioral, image, and lesion location data - have lagged behind. Such tools are especially critical to patient-based research given that finding patients who meet the inclusion/exclusion requirements of a given study is often a bottleneck in completing studies. Ideally, such tools should facilitate both local and collaborative research while conforming to regulatory constraints. However, at present many researchers rely on ad-hoc data management approaches that don't support the full range of databasing needs. We propose to develop a free software system for managing patient data, appropriate to the needs of researchers studying cognitive function in neurological populations. Our proposal includes two main components. The first is a portable, free database system designed to be easily adapted to local needs and to facilitate sharing resources to the extent permitted by prevailing regulations. The system is extensible, readily installed on a variety of platforms, and suitable for a range of scales, from desktop use for individual researchers to inter-institutional collaborations. The second component of our proposal is a system for managing and combining lesion location information of widely varying quality, ranging from high-resolution MRI to hand-drawn sketches, by incorporating localization error into the assessment of the probability that a lesion encompasses or overlaps a given region. This system will allow the construction of probabilistic lesion maps for use in research, as well as database search on the basis of lesion location, with probabilistic rather than all-or-none criteria.

长期以来，对脑损伤患者的研究一直是了解人类认知功能的关键方法。但是，用于管理基于患者研究的数据的方法和工具（包括人口统计学，行为，图像和病变位置数据）已落后。对于基于患者的研究，这种工具尤其至关重要，因为发现符合给定研究的纳入/排除要求的患者通常是完成研究的瓶颈。理想情况下，这样的工具应促进本地和协作研究，同时符合监管限制。但是，目前，许多研究人员依靠不支持全部数据表需求的临时数据管理方法。我们建议开发一个自由软件系统来管理患者数据，适合研究神经系统认知功能的研究人员的需求。我们的建议包括两个主要组成部分。首先是一种便携式，免费的数据库系统，旨在轻松适应本地需求，并在盛行法规允许的范围内促进共享资源。该系统是可扩展的，很容易安装在各种平台上，适用于各种规模，从桌面使用供单个研究人员使用到机构间合作。我们提案的第二个组成部分是一个系统，用于管理和组合质量变化的病变位置信息，从高分辨率MRI到手绘草图，通过将定位错误纳入评估病变包含或重叠给定区域的概率的评估中。该系统将允许构建概率病变图在研究中使用，以及根据病变位置的数据库搜索，具有概率而不是全或任何标准。

项目成果

Support for anterior temporal involvement in semantic error production in aphasia: new evidence from VLSM.

• DOI: 10.1016/j.bandl.2010.09.008
• 发表时间: 2011-06
• 期刊: BRAIN AND LANGUAGE
• 影响因子: 2.5
• 作者: Walker, Grant M.;Schwartz, Myrna F.;Kimberg, Daniel Y.;Faseyitan, Olufunsho;Brecher, Adelyn;Dell, Gary S.;Coslett, H. Branch
• 通讯作者: Coslett, H. Branch