CORE--POPULATION STUDIES

核心——人口研究

• 批准号: 7310511
• 负责人: Robert C Young
• 金额: $ 13.71万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7310511
• 关键词: biomedical facility; cancer information system; data management; experimental designs; neoplasm /cancer epidemiology

The number of large and logistically intricate research studies at Fox Chase Cancer Center (FCCC) has been steadily increasing. Many FCCC studies, including those in epidemiology, cancer control and prevention, translational research, human genetics, behavioral medicine and some animal trials employ a variety of designs that are substantially more complex than typical cancer clinical trials at FCCC. The designs of these studies often include: unique questionnaires, clinical and specimen data from large numbers of individuals (ranging from hundreds to tens of thousands); collection of longitudinal data; collection, storage and graphical display of pedigree data; online data entry and retrieval at multiple geographically distant centers; data collection using computer-aided telephone interview systems; development of specimen inventory systems; case-control and nested case-control study designs; distribution of scheduled, personalized mailings, and the collection, integration, coordination and retrieval of information generated from diverse sources and potentially stored in multiple systems. The varied populations studied in these projects and the diversity and complexity of the designs require development of study-specific computer-based tools to provide project management and coordination, and for the collection, validation, storage, and retrieval of data. The Population Studies Facility (PSF) facilitates research conducted by FCCC investigators with peer-reviewed funding by providing them access to a productive team of skilled information systems professionals. PSF personnel have substantial expertise with states-of-the-art software engineering and design as applied to cancer research. The PSF functions include development of: (a) databases for the storage and manipulation of large quantities of questionnaire, clinical, and specimen data; (b) electronic data entry and retrieval systems; (c) report generation software; (d) consistency and quality control systems; and (e) systems that provide integration and controlled exchange of data from diverse sources. The PSF developed information systems that maintain data on over 148,000 study subjects. Over the last five years, the Facility provided services to 40 investigators with peer-reviewed funding in 10 Programs from all three Divisions, representing a 38% increase over the previous funding cycle. 99% of Facility use is by investigators with peer-reviewed funding.

Fox Chase癌症中心的大型和逻辑上复杂的研究的数量 （FCCC）一直在稳步增加。许多FCCC研究，包括流行病学，癌症控制和预防，翻译研究，人类遗传学，行为医学和某些动物试验的研究，采用了多种设计，这些设计比FCCC的典型癌症临床试验要复杂得多。这些研究的设计通常包括：来自大量个体的独特问卷，临床和标本数据（从数百到数万个人不等）；纵向数据的收集；谱系数据的收集，存储和图形显示；在线数据输入和在多个地理遥远的中心检索；使用计算机辅助电话采访系统收集数据；制定标本库存系统；病例对照和嵌套的病例对照研究设计；计划，个性化邮件的分布以及从不同来源生成的信息的收集，集成，协调和检索，并可能存储在多个系统中。这些项目中研究的各种人群以及设计的多样性和复杂性需要开发基于研究的计算机工具，以提供项目管理和协调，并为数据的收集，验证，存储和数据检索。人口研究机构（PSF）通过为他们提供了一支熟练的信息系统专业人员的富有成效的团队，从而促进了FCCC研究人员进行同行评审资金进行的研究。 PSF人员在现状软件方面具有丰富的专业知识 适用于癌症研究的工程和设计。 PSF功能包括： （a）存储和操纵大量问卷，临床和 标本数据； （b）电子数据输入和检索系统； （c）报告生成软件； （d）一致性和质量控制系统； （e）提供来自不同来源数据的集成和控制交换的系统。 PSF开发了信息系统，可维护148,000多名研究对象的数据。在过去的五年中，该设施为40名调查人员提供了服务，并在所有三个部门的10个计划中进行了同行评审的资金，这比以前的资金周期增加了38％。 99％的设施使用是通过同行评审资金进行的调查人员。