CORE

核

• 批准号: 7640625
• 负责人: Michael T Bardo
• 金额: $ 14.25万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7640625
• 关键词: Adolescence; Advocate; Basic Science; Cell physiology; Commit; Communities; Drug abuse; Drug usage; Educational workshop; Electroencephalography; Environment; Esthesia; Faculty; Functional Magnetic Resonance Imaging; Funding; Goals; Human Resources; Human Volunteers; Illicit Drugs; Individual; Individual Differences; Institution; International; Laboratories; Laboratory Rat; Leadership; Link; Measures; Modeling; Neurophysiology - biologic function; Personality; Pharmaceutical Preparations; Positioning Attribute; Prevention; Prevention intervention; Process; Professional Organizations; Publications; Publishing; Range; Research; Research Personnel; Resources; Rewards; Risk; Role; Science; Scientist; Self Administration; Series; Services; Structure; Students; Testing; Thinking; Training; Translating; Translations; Work; base; cohort; college; design; drug abuse prevention; drug reward; high school; implementation science; interdisciplinary collaboration; neurobehavioral; next generation; outreach; programs; psychologic; psychosocial; relating to nervous system; research study; research to practice; response; social; symposium; trait; young adult

The current renewal application for the Center for Drug Abuse Research Translation (CDART) consists of a core and four projects that are linked around the central theme that individual differences in personality are important predictors of drug abuse vulnerability during adolescence and young adulthood. Previous work in our center and other laboratories has identified sensation seeking as a critical personality construct associated strongly with drug use, especially use of illicit drugs. In the current proposal, sensationseeking will be divided into two separate constructs, namely, reward seeking and inhibition, both of which are thought to be associatedwith drug use. In Project 1 (Bardo, PI), a laboratory rat model will be used to determine if individual differences in reward seeking and inhibition are associated with stimulant drug self-administration and mesocorticolimbic cellular processes. In Project 2 (Kelly, PI), human volunteers will be used to assess if individual differences in reward seeking and inhibition are associated with differences in drug self- administration and neural function as measured by fMRI and EEC. In Project 3 (Lynam, PI), a cohort of students transitioning from high school to college will be used to determine if individual differences in reward seeking and inhibition are associated with the initiation, escalation and/or cessation of drug use in a longitudinal design. In Project 4 (Zimmerman, PI), students will be used in experimental reserch designed to evaluate if individuals who vary in reward seeking and inhibition show a differential response to televised anti-drug public service announcements. There are three specific aims in the Core: one scientific, one organizational, and one that involves continuing and expanding leadership in translating the prevention science and drug abuse research communities. In relation to the four projects, some key functions of the Core are to: (1) provide thematic scientific integration of the different projects around the constructs of reward seeking and inhibition; (2) create synergy across the four proposed projects and other ongoing projects on campus; (3) facilitate interdisciplinary collaboration among basic and prevention sciences using both neurobehavioral and psychosocial levels of analysis; and (4) oversee the long-range goal of translating our basic research into practice by designing more effective anti-drug public service announements that target at-risk young adults.

目前的药物滥用研究中心申请（CDART）由 核心和四个围绕中心主题链接的项目，个性个性差异是 青春期和成年期间药物滥用脆弱性的重要预测因素。以前的工作 我们的中心和其他实验室已经确定了寻求的感觉是一种关键的个性构建 与吸毒的强烈相关，尤其是使用非法药物。在当前的提案中，轰动会 将分为两个独立的构造，即寻求和抑制，这两者都被认为 与吸毒相关。在项目1（Bardo，PI）中，将使用实验室大鼠模型来确定是否是否 寻求奖励和抑制的个体差异与刺激性药物自我管理有关 和中质体细胞过程。在项目2（凯利，PI）中，将使用人类志愿者来评估是否存在 寻求奖励和抑制的个体差异与药物自我差异有关 通过fMRI和EEC测量的给药和神经功能。在项目3（Lynam，pi）中 从高中过渡到大学的学生将用于确定奖励的个体差异是否存在 寻求和抑制与A中的启动，升级和/或停止使用 纵向设计。在项目4（Zimmerman，pi）中，学生将用于实验性的研究中 评估在寻求奖励和抑制方面有所不同的个人是否对电视转播有所不同 反毒品公共服务公告。 核心中有三个具体目标：一个科学，一个组织，一个涉及 继续和扩大领导才能翻译预防科学和药物滥用研究 社区。关于四个项目，核心的一些关键功能是：（1）提供主题 围绕寻求奖励和抑制的构建的不同项目的科学整合； （2） 在校园内的四个拟议项目和其他正在进行的项目中创造协同作用； （3）便利 使用神经行为和预防科学之间的跨学科合作 社会心理分析水平； （4）监督将我们的基础研究转化为 通过设计更有效的防毒公共服务宣布，以针对危险的年轻人进行练习。