Risk Factors for Hot Flashes in Mid-Life Women

中年女性潮热的危险因素

• 批准号: 7664974
• 负责人: Jodi A. Flaws
• 金额: $ 54.6万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664974
• 关键词: 3-Hydroxysteroid Dehydrogenases; Acute; Androgen Receptor; Androgens; Androstenedione; Anxiety; Aromatase; Attenuated; Biological Assay; Blood specimen; Boxing; CYP1A1 gene; CYP1B1 gene; Candidate Disease Gene; Caring; Catechol Estrogens; Catechols; Chills; Cytochrome P450; Cytochromes; Data; Development; Enzymes; Estradiol; Estriol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Estrone; Event; Face; Failure; Flushing; Funding; Future; Gene Frequency; Genes; Genetic Polymorphism; Genotype; Glucuronides; Goals; Gonadal Steroid Hormones; Heating; Hormones; Hot flushes; Knowledge; Lead; Life; Link; Logistic Regressions; Longitudinal Studies; Measurement; Measures; Mediating; Medical; Menopause; Metabolism; Methods; Modeling; Non obese; Obesity; Ovarian; Ovarian Follicle; Palpitations; Pathway interactions; Perimenopause; Phase; Predisposing Factor; Prevention strategy; Principal Investigator; Progesterone; Public Health; Publications; Quality of life; Questionnaires; Radioimmunoassay; Regression Analysis; Reporting; Research Design; Research Personnel; Risk; Risk Factors; Serum; Sex Hormone-Binding Globulin; Side; Skin; Sleep disturbances; Statistical Models; Steroids; Survival Analysis; Sweat; Sweating; Symptoms; Testing; Testosterone; Time; Tissues; Transferase; Transvaginal Ultrasound; United States; Upper arm; Visit; Woman; Work; base; case control; cigarette smoking; dehydroepiandrosterone; depression; design; experience; medical attention; middle age; neutrophil; novel strategies; prevent; programs; receptor; response; sex; steroid hormone receptor

DESCRIPTION (provided by applicant): Hot flashes pose a significant public heath problem because they are the most common perimenopausal symptom reported by women in the United States and the primary reason that women seek medical care during the menopausal transition. Despite the public health importance of hot flashes, little is known about the factors that predispose women to hot flashes. During the previous funding period, new preliminary data were obtained that indicate that obesity increases the risk of perimenopausal hot flashes. Thus, the overall goal of this renewal application is to examine the mechanism by which obesity increases the risk of hot flashes. Specifically, the proposed work will test the hypothesis that obesity is associated with hot flashes through mechanisms that involve early ovarian failure, altered sex steroid hormone levels, and selected genetic polymorphisms in steroidogenic enzymes and steroid hormone receptors. The specific aims are to determine whether: 1) obesity is associated with early ovarian follicle loss and altered levels of sex steroid hormones, 2) obesity is associated with selected polymorphisms in genes that encode enzymes that synthesize and degrade sex steroids and/or receptors that respond to sex steroids, 3) selected polymorph- isms are associated with sex steroid hormone levels, and 4) the association between obesity and hot flashes is mediated by early ovarian follicle loss, altered hormone levels, and/or selected genetic polymorphisms. To complete these aims, obese and non-obese perimenopausal women with and without hot flashes will complete questionnaires, receive transvaginal ultrasounds for measurement of ovarian volume and follicle numbers, and provide blood samples for measurement of selected sex steroid hormones and genetic polymorphisms in steroidogenic enzymes and steroid hormone receptors. Ovarian volume, follicle numbers, sex steroid hormone levels, and the odds of having selected genetic polymorphisms will be compared in obese and non-obese women using appropriate statistical tests. Further, statistical models will be used to determine whether the association between obesity and hot flashes is attenuated by adjustment for ovarian volume, follicle numbers, sex steroid hormone levels, and selected genetic polymorphisms. The results of this study will provide information about risk factors for perimenopausal hot flashes. In turn, this information may be useful for the future development of novel strategies to prevent or treat hot flashes.

描述（由申请人提供）：潮热引起了一个重大的公共荒地问题，因为它们是美国妇女报告的最常见的围绝经症状，也是妇女在绝经期间寻求医疗护理的主要原因。尽管公众健康的潮流具有重要的重要性，但对使女性易受潮热的因素知之甚少。在上一个融资期间，获得了新的初步数据，表明肥胖会增加围绝经内闪光的风险。因此，这种更新应用的总体目标是检查肥胖增加潮热风险的机制。具体而言，提出的工作将检验以下假设：肥胖与涉及早期卵巢衰竭，性类固醇激素水平改变的机制以及在类固醇激素和类固醇激素受体中选择的遗传多态性有关。具体目的是确定：1​​）肥胖是否与早期卵巢卵泡损失和性类固醇激素水平改变有关，2）肥胖与编码合成和降解性固醇和/或受体的基因中选定的多态性有关对性类固醇的反应，3）选定的多态性ISM与性类固醇激素水平相关，4）肥胖和潮热之间的关联是由早期卵巢卵泡损失，激素水平改变和/或选择的遗传多态性介导的。为了完成这些目的，有或没有潮热的肥胖和非肥胖围绝经儿童将完成问卷调查，接受经阴道的超声检查以测量卵巢量和卵泡数量，并提供血液样本，以测量选定的性类固醇激素和遗传性甲酶的遗传学多态性的血液样本和类固醇激素受体。使用适当的统计检验，将比较肥胖和非肥胖女性中选择遗传多态性的卵巢量，卵泡数量，性类固醇激素水平以及选择遗传多态性的几率。此外，将使用统计模型来确定肥胖和潮热之间的关联是否通过调整卵巢量，卵泡数量，性类固醇激素水平以及选定的遗传多态性而减弱。这项研究的结果将提供有关围绝经内闪光的风险因素的信息。反过来，此信息可能对预防或治疗潮热的新型策略的未来发展可能很有用。