Intervening with HIV+ Alcohol Abusers: Influence of Neuro-Behavioral Factors

对艾滋病毒酗酒者进行干预：神经行为因素的影响

• 批准号: 7652453
• 负责人: ROBERT Michael MALOW
• 金额: $ 78.93万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7652453
• 关键词: AIDS prevention; AIDS/HIV problem; Acute; Address; Adherence; Adult; Affect; African American; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Area; Behavior; Behavior Therapy; Behavioral; Biological; Blood Tests; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Chronic; Cognitive; Collaborations; Communication; Consensus; Diffusion; Dopamine; Drug abuse; Drug usage; Epidemic; Equilibrium; Ethics; Evidence based intervention; Female; Genetic; Genetic Determinism; HIV; HIV Seropositivity; Health; Health Promotion; Hispanics; Holistic Health; Hour; Hygiene; Individual; Informed Consent; Intervention; Intervention Studies; Life; Link; Low income; Manuals; Mediating; Memory; Minority; Modeling; Molecular Genetics; Moods; Motivation; Outcome; Patient Self-Report; Pharmaceutical Preparations; Play; Population; Poverty; Prevention; Prevention approach; Preventive; Preventive Intervention; Problem Solving; Problem behavior; Procedures; Protocols documentation; Psychiatric Social Work; Quality of life; Randomized; Randomized Controlled Trials; Recommendation; Recording of previous events; Recovery; Research; Research Design; Research Personnel; Resources; Risk; Risk Behaviors; Risk Reduction; Role; Safe Sex; Sampling; Schedule; Screening procedure; Self Management; Serotonin; Services; Sexual Transmission; Site; Social support; Specific qualifier value; Subgroup; Target Populations; Testing; Therapeutic; Time; Uninsured; Violence; Woman; Work; alcohol and other drug; base; biological research; cognitive function; cohort; community based treatment; community setting; comparison group; condoms; coping; design; evidence base; executive function; experience; follow up assessment; follow-up; health care service utilization; health disparity; improved; information processing; insight; intervention effect; male; medication compliance; men; multidisciplinary; neuropsychological; neurotransmission; post intervention; primary outcome; programs; prospective; psychosocial; response; safer sex; secondary outcome; sex risk; skills; theories; therapy design; transmission process; treatment effect; urban area

DESCRIPTION (provided by applicant): The proposed randomized controlled study will attempt to reduce HIV sexual transmission risk and substance use, increase the utilization of primary HIV care services, and improve psychosocial health among a sample of 320 alcohol abusing, HIV+ individuals. The experimental intervention will include an adaptation of the Holistic Health Recovery Program (HHRP; Margolin et al., 2003) that is the only evidence-based, HIV+ intervention for improving sexual risk and adherence outcomes for an addicted population. For this study, the intervention will be adapted for use in a culturally diverse, alcohol abusing sample. HHRP will be compared to a Health Promotion Comparison (HPC) condition, which addresses common health problems, including personal hygiene and healthy living. Specific aims include: 1) comparing the adapted HHRP to the HPC condition to evaluate if HHRP reduces HIV sexual transmission risk, alcohol and other drug use, and improves the utilization of primary HIV care services and psychosocial health; 2) evaluating how Information, Motivation, Behavioral Skills mediate intervention effects on safe sex outcome; and 3) evaluating how key neuropsychological and molecular-genetic factors moderate the effect of the intervention on HIV transmission risk outcomes. Recruitment sites are primarily located in densely populated, multicultural, low income, urban areas of Miami with high rates of AOD abuse, HIV, violence and poverty, with the vast majority of the population being uninsured and suffering from multiple health disparities. The study is a prospective, randomized by cohort two-group design. The scheduled sequence of procedures will be: a) informed consent, screening, and baseline assessment; b) a 120 minute group session of HHRP or HPC sessions administered once a week for 12 consecutive weeks; and c) a post- intervention assessment. Follow-up assessment protocols will be administered at 3, 6, and 12 months post-intervention. Neuropsychological and blood tests for molecular/genetic typing will also be conducted to assist in identifying factors which may influence the impact of the intervention study. The proposed study will attempt to reduce HIV sexual transmission risk and substance use among a sample of alcohol abusing, HIV+ individuals. In studying the memory, information processing, executive functioning as well as genetic factors of the individuals of this study, researchers will be better able to discern those factors which may have an impact on treatment effects. This study therefore has the potential to identify individual characteristics that may contribute to specific reductions in risky behaviors in this sample.

描述（由申请人提供）：拟议的随机对照研究将试图减少HIV性传播风险和药物使用，增加原发性HIV护理服务的利用，并改善320个滥用酒精的HIV+个体样本中的社会心理健康。实验干预措施将包括对整体健康恢复计划的改编（HHRP； Margolin等，2003），该计划是唯一基于证据的HIV+干预措施，用于改善上瘾人群的性风险和依从性结果。在这项研究中，干预措施将用于用于滥用饮酒样本的文化多样性。将HHRP与健康促进比较（HPC）条件进行比较，该条件解决了常见的健康问题，包括个人卫生和健康生活。具体目的包括：1）将改编的HHRP与HPC条件进行比较，以评估HHRP是否降低了HIV性传播风险，酒精和其他药物的使用，并改善对原发性HIV护理服务和心理社会健康的利用； 2）评估信息，动机，行为能力如何介导干预对安全性结果的影响； 3）评估关键神经心理学和分子遗传因素如何适应干预对HIV传播风险结果的影响。招聘场所主要位于人口稠密，多元文化，低收入，迈阿密城市地区，其AOD滥用，艾滋病毒，暴力和贫困率很高，绝大多数人口都没有保险，并且患有多种健康差异。该研究是一项前瞻性，由队列两组设计随机分配。预定的程序顺序将是：a）知情同意，筛选和基线评估； b）每周一次进行120分钟的HHRP或HPC会话，连续12周进行； c）干预后评估。后续评估方案将在干预后3、6和12个月下进行。还将进行分子/遗传分类的神经心理学和血液测试，以帮助识别可能影响干预研究影响的因素。 拟议的研究将试图减少滥用酗酒的HIV+个体样本中的HIV性传播风险和物质使用。在研究本研究个体的记忆，信息处理，执行功能以及遗传因素时，研究人员将更好地辨别可能会影响治疗效果的因素。因此，这项研究有可能确定可能导致该样本中风险行为的特定特征的个体特征。