Improve the diagnostic accuracy of CBCT for oral lesions

提高CBCT对口腔病变的诊断准确性

• 批准号: 10427072
• 负责人: OTTO Z ZHOU
• 金额: $ 51.23万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-02 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427072
• 关键词: Algorithms; Cancer Patient; Carbon Nanotubes; Clinical; Collimator; Computer software; Data Set; Dental; Dental Clinics; Dental Prosthesis; Dentistry; Detection; Development; Devices; Diagnosis; Diagnostic Neoplasm Staging; Dose; Early Diagnosis; Early treatment; Exposure to; Goals; Healthcare Systems; Image; Imaging Device; Imaging technology; Iodine; Magnetic Resonance Imaging; Malignant Neoplasms; Medical Imaging; Metals; Modeling; Modification; Morphologic artifacts; Neoplastic Processes; Oral Diagnosis; Patient imaging; Patients; Performance; Production; Prognosis; Radiation Scattering; Radiation exposure; Research; Resolution; Roentgen Rays; Role; Scientist; Screening for Oral Cancer; Source; Specificity; Spottings; Staging; Survival Rate; System; Technology; Translating; United States; X-Ray Computed Tomography; base; bone invasion; cancer imaging; cancer type; clinical practice; cone-beam computed tomography; contrast enhanced; cost; design; design and construction; detection sensitivity; detector; diagnostic accuracy; driving force; experience; imaging capabilities; imaging modality; improved; malignant mouth neoplasm; maxillofacial; multidisciplinary; oral lesion; prototype; radiologist; reconstruction; screening; soft tissue; spectral energy; tumor; virtual

ABSTRACT Oral cancer accounts for 2.5% of all cancers in the United States. It has one of the lowest five-year survival rates among the major cancer types. Early diagnosis and treatment are critical to improve the prognosis of oral cancer patients. Contrast enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are currently the most widely accepted imaging modalities for diagnosis and staging of oral cancer. However, because of their high cost, high patient radiation exposure (CT), and large footprint, CT and MRI are not the standard imaging modalities used in dental clinics. In addition, oral lesions in the CT images are frequently obscured by metal artifacts caused by dental prostheses, reducing the sensitivity and increasing false diagnosis. CT is known to have a high specificity but low sensitivity for detection of oral cancers. Cone beam CT (CBCT) reduces the radiation exposure to the patient, the cost to purchase and to operate, as well as the footprint, compared to CT. It has found wide applications in dentistry. However, CBCT’s role in oral cancer imaging and staging is currently limited, despite its wide availability. This is primarily due to its poor soft tissue contrast resolution, which makes it difficult to visualize the tumor mass, and neoplastic processes are frequently overlooked. The role of CBCT in preoperative assessment of bone invasion from oral cancer has been evaluated in only a few studies with inconsistent results. The presence of strong metal artifacts also degrades the quality of the CBCT images, as in the case of CT. We propose a multisource spectral volumetric CT (mSCT) technology to 1) increase the soft tissue contrast of dental CBCT; 2) reduce the image metal artifacts; and 3) improve the tumor delineation in contrasted CT imaging. These will be achieved by 1) retrofitting the conventional CBCT with a unique carbon nanotube (CNT) x-ray source array invented by our team; and 2) incorporating dual energy CT (DECT) and virtual monoenergetic image (VMI) capabilities at low cost. The device maintains all the clinical functionality and utility of CBCT and its desirable attributes. The technology has the potential to not only enable precision imaging of oral lesions using the widely available CBCT after modification, reducing the cost and patient radiation exposure compared to the current clinical practice, but also improve earlier detection of oral cancer through either screening or/and opportunistic imaging. The Specific Aims are: 1) Optimizing mSCT to achieve high soft tissue contrast resolution; 2) Reducing metal artifacts and improving tumor delineation by incorporating spectral filter based dual-energy and virtual monoenergetic imaging; 3) Constructing a prototype mSCT scanner and characterizing its system performance; and 4) Demonstrating increased soft tissue contrast, reduced metal artifact and improved oral lesion delineation in mSCT compared to CBCT.

抽象的 口腔癌占美国所有癌症的 2.5%，是五年生存率最低的癌症之一。 主要癌症类型的早期诊断和治疗对于改善口腔预后至关重要。 癌症患者进行对比增强计算机断层扫描 (CT) 和磁共振成像 (MRI)。 目前最广泛接受的口腔癌诊断和分期成像方式。 由于成本高、患者辐射暴露 (CT) 高且占地面积大，CT 和 MRI 并不适用 此外，CT 图像中经常出现口腔病变。 被假牙造成的金属伪影掩盖，降低了灵敏度并增加了误诊。 众所周知，CT 对于口腔癌的检测具有较高的特异性，但敏感性较低。 锥形束 CT (CBCT) 减少了患者的辐射暴露、购买和操作成本， 与 CT 相比，它在牙科领域有着广泛的应用。 尽管口腔癌成像和分期广泛可用，但目前仍有限，这主要是由于其较差。 软组织对比度分辨率，这使得肿瘤块的可视化变得困难，并且肿瘤过程是 CBCT 在口腔癌骨侵犯术前评估中的作用经常被忽视。 仅在少数研究中进行了评估，结果也不一致。 与 CT 一样，会降低 CBCT 图像的质量。 我们提出了一种多源能谱体积 CT (mSCT) 技术来 1) 增加软组织对比度 牙科 CBCT；2) 减少图像金属伪影；3) 改善对比 CT 中的肿瘤勾画； 这些将通过以下方式实现：1) 用独特的碳纳米管 (CNT) 改造传统的 CBCT。 我们团队发明的X射线源阵列；2）结合双能CT（DECT）和虚拟单能 该设备以低成本保留了 CBCT 的所有临床功能和实用性。 该技术不仅有潜力实现口腔病变的精确成像。 使用经过修改后广泛使用的CBCT，与相比降低了成本和患者辐射暴露 根据当前的临床实践，还可以通过筛查或/和提高口腔癌的早期检测 机会成像。 具体目标是： 1) 优化 mSCT 以实现高软组织对比度分辨率 2) 减少金属； 通过结合基于光谱滤波器的双能和虚拟技术来消除伪影并改善肿瘤轮廓 单能成像；3）构建原型 mSCT 扫描仪并表征其系统性能； 4) 展示软组织对比度的增加、金属伪影的减少以及口腔病变轮廓的改善 mSCT 与 CBCT 相比。

项目成果

Evaluation of the feasibility of a multisource CBCT for maxillofacial imaging.

评估颌面成像多源 CBCT 的可行性。

• 发表时间: 2023-08-14
• 影响因子: 3.5
• 作者: Xu, Shuang;Li, Boyuan;Inscoe, Christina R;Bastawros, Daniel;Tyndall, Donald A;Lee, Yueh Z;Lu, Jianping;Zhou, Otto
• 通讯作者: Zhou, Otto

Improving the accuracy of bone mineral density using a multisource CBCT.

使用多源 CBCT 提高骨矿物质密度的准确性。

• 发表时间: 2024-02-16
• 影响因子: 4.6
• 作者: Hu, Yuanming;Xu, Shuang;Li, Boyuan;Inscoe, Christina R;Tyndall, Donald A;Lee, Yueh Z;Lu, Jianping;Zhou, Otto
• 通讯作者: Zhou, Otto

Volumetric computed tomography with carbon nanotube X-ray source array for improved image quality and accuracy.

采用碳纳米管 X 射线源阵列的体积计算机断层扫描可提高图像质量和准确性。

• 发表时间: 2023
• 作者: Xu, Shuang;Hu, Yuanming;Li, Boyuan;Inscoe, Christina R;Tyndall, Donald A;Lee, Yueh Z;Lu, Jianping;Zhou, Otto
• 通讯作者: Zhou, Otto