Neural and behavioral correlates of deliberate emotion regulation in early childhood: testing unique links to emerging irritability.

幼儿期刻意情绪调节的神经和行为相关性：测试与新出现的烦躁的独特联系。

• 批准号: 10228731
• 负责人: Adam Grabell
• 金额: $ 17.28万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228731
• 关键词: Age; Anger; Behavior; Behavioral; Child; Clinical; Data; Development; Diagnostic; Dimensions; Early Intervention; Electroencephalography; Emotional; Etiology; Facial Expression; Foxes; Frequencies; Frustration; Future; Growth; Heterogeneity; Individual Differences; Intervention; Link; Literature; Major Mental Illness; Measures; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Mission; Near-Infrared Spectroscopy; Nursery Schools; Parents; Population; Predisposition; Prefrontal Cortex; Property; Psychopathology; Regulation; Research; Research Design; Sampling; Severities; Signal Transduction; Specificity; Stimulus; Symptoms; Testing; Training; Translating; Treatment Efficacy; Visit; Work; associated symptom; design; early childhood; effective therapy; emotion regulation; executive function; follow-up; innovation; interest; longitudinal design; member; neuroimaging; neuroregulation; novel; novel strategies; peer; programs; protective factors; recruit; relating to nervous system; response; skills; statistics; translational research program

7. Project Summary. Irritability is a relative predisposition for angry responses to frustration that exists, at some level, in every member of the population, but at the severe end is a symptom transversing the internalizing and externalizing spectra and forecasting future mental illness. There has been increased interest in elucidating the specific deficits that 1) discriminate early irritability that is and is not prodromal to mental illness, and 2) could be reduced through novel intervention. Irritability is modulated by emotion regulation, which can be parsed into non-mutually exclusive automatic (immediate, reactive) and deliberate (longer-unfolding, effortful) response types. Deliberate emotion regulation, more so than automatic, requires greater prefrontal cortex activation and engagement of executive function for successful implementation, and thus may be a better auger of irritability severity and course and a more viable clinical target. However, deliberate emotion regulation is difficult to measure in early childhood and has been under-researched. The proposed Mentored Patient-Oriented Research Career Development Award will train the candidate to probe deliberate regulation in preschoolers ranging from low to severe irritability, over a period of rapid development, and connect findings to translational implications. The candidate's current expertise includes differentiating the normal:abnormal spectrum of emergent psychopathology, with a focus on early disruptive behavior, multivariate statistics, and some basic skills in acquiring and analyzing EEG and functional Near Infrared Spectroscopy (fNIRS) data. To launch a translational program of research that connects a detailed understanding of emotion regulation to emerging psychopathology and more effective treatments, the candidate seeks advanced training in 1) a multi-level approach linking emerging emotion regulation with irritability, 2) developing more refined treatment implications, and 3) longitudinal research. The candidate's mentorship team, Drs. Perlman, Wakschlag, Huppert, Kolko, Molina, and Fox, provide expertise in child neuroimaging, emotion regulation, and irritability, longitudinal design, and child treatment efficacy. The proposed study will examine early deliberate emotion regulation, its association with level of concurrent irritability, and changes in irritability, internalizing, and externalizing symptoms one year later. Children ages 3 and 5 years (n = 50) ranging from low to severe irritability will complete a validated automatic emotion regulation task followed by a novel deliberate emotion regulation task. An innovative multi-level approach will be used to isolate deliberate from automatic emotion regulation by simultaneously recording dorsolateral prefrontal cortex activation via fNIRS and facial expression via video. Children will complete the paradigm again one year later and parents will rate their child's irritability, internalizing, and externalizing symptoms at baseline and follow-up. The proposed study is designed to shift the field to focusing on deliberate emotion regulation, inform future longitudinal work, and spur novel interventions for early irritability. !

7. 项目概要。 烦躁是对挫折做出愤怒反应的相对倾向，在某种程度上存在于每个人身上。 人口中的一员，但最严重的是一种跨越内化和外化的症状 光谱并预测未来的精神疾病。人们越来越有兴趣阐明具体的 缺陷：1）区分早期的烦躁，它是和不是精神疾病的前兆，2）可能是 通过新颖的干预措施减少。烦躁是通过情绪调节来调节的，情绪调节可以解析为 非相互排斥的自动（立即，反应性）和深思熟虑（较长时间展开，努力）响应 类型。刻意的情绪调节，比自动的更需要更多的前额皮质激活和 执行职能的参与才能成功实施，因此可能会更好地缓解烦躁情绪 严重程度和病程以及更可行的临床目标。然而，刻意的情绪调节却很难 儿童早期的测量，但尚未得到充分研究。 拟议的以患者为导向的研究职业发展奖将培训候选人 探究学龄前儿童在一段快速的时期内从低度到严重烦躁的刻意调节 发展，并将发现与转化意义联系起来。候选人目前的专业知识包括 区分正常：突发精神病理学的异常谱，重点是早期破坏性 行为、多元统计以及获取和分析脑电图和功能性近场的一些基本技能 红外光谱 (fNIRS) 数据。启动一项转化研究计划，将详细的 对情绪调节的理解对新兴的精神病理学和更有效的治疗， 候选人寻求以下方面的高级培训：1）将新兴情绪调节与 烦躁，2）开发更精细的治疗意义，3）纵向研究。候选人的 导师团队，博士。 Perlman、Wakschlag、Huppert、Kolko、Molina 和 Fox 提供儿童方面的专业知识 神经影像学、情绪调节和烦躁、纵向设计和儿童治疗功效。 拟议的研究将检查早期刻意的情绪调节及其与情绪水平的关系 并发的烦躁，以及一年后烦躁、内化和外化症状的变化。 3 岁和 5 岁的儿童 (n = 50) 烦躁程度从低到重度不等，将完成经过验证的自动测试 情绪调节任务之后是新颖的刻意情绪调节任务。创新的多层次 方法将用于通过同时记录来隔离故意情绪调节和自动情绪调节 通过 fNIRS 激活背外侧前额皮质，通过视频激活面部表情。孩子们将完成 一年后再次进行范式，父母会对孩子的易怒性、内化性和外化性进行评分 基线和随访时的症状。拟议的研究旨在将领域转向有意的研究 情绪调节，为未来的纵向工作提供信息，并刺激针对早期烦躁的新颖干预措施。 ！