Systems Biology: A Foundation for Interdisciplinary Careers

系统生物学：跨学科职业的基础

• 批准号: 10229407
• 负责人: German Andres Enciso
• 金额: $ 29.99万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10229407
• 关键词: Area; Biological Sciences; Biology; Biomedical Research; Collaborations; Communication; Complex; Data Analyses; Data Set; Educational process of instructing; Educational workshop; Engineering; Exercise; Faculty; Fellowship; Female; Financial Support; Fostering; Foundations; Gene Expression Regulation; Generations; Goals; Growth; Individual; Information Dissemination; Infrastructure; Instruction; Interdisciplinary Study; Knowledge; Laboratories; Light; Logistics; Mathematics; Mentors; Methodology; Methods; Minority; Modeling; Modernization; Molecular; Morphogenesis; National Institute of General Medical Sciences; Nature; Output; Participant; Pattern Formation; Physics; Postdoctoral Fellow; Preparation; Professional Competence; Research; Research Activity; Research Personnel; Scientist; Signal Transduction; Site; Software Tools; Statistical Models; Students; Systems Biology; Technical Expertise; Testing; Training; Training Activity; Underrepresented Minority; United States National Institutes of Health; Visit; Vocabulary; Woman; Work; biological research; career; career development; cohort; community building; complex biological systems; computer science; data acquisition; design; experience; follow-up; genome-wide analysis; graduate student; imaging properties; innovation; interdisciplinary approach; laboratory experiment; laboratory module; lectures; mathematical model; member; online resource; outreach; programs; receptor; recruit; research and development; skill acquisition; skills; symposium; synthetic biology; theories; tool

We propose a program to enhance the training and career development of scientists who seek to undertake interdisciplinary biological and biomedical research that draws upon ideas and tools from mathematics, physics, engineering and computer science, as embodied by the young field of Systems Biology. The program is centered upon a three-week intensive course at UC Irvine, followed by one to two years of follow-up mentoring and career development activity. The course is intended for graduate students, postdocs and more advanced scientists, both those with backgrounds in experimental biology—who typically need additional preparation in mathematics and computation—and those with backgrounds in mathematics, physics, engineering or computer science—who usually need additional preparation in the foundations of biology. We aim to train around 20 individuals each year. The proposed program begins with a one-week preparatory workshop, followed by a two-week core course in which lectures and laboratory modules will expose participants to cutting-edge interdisciplinary methodologies and research topics. The program will also feature extensive mentoring and career-skill building activities, including panel discussions, presentations, mentored team projects, and individually-guided development of research or fellowship proposals. These activities will involve 27 UCI faculty with research and teaching expertise in mathematics, physics, computer science, engineering and the biological sciences. Outreach activities include dissemination of information through online resources and a systems biology regional conference, as well as participation in workshops at interdisciplinary and minority conferences. The specific goals of the course include (i) conveying an understanding of Systems Biology and its interdisciplinary nature; (ii) filling gaps in technical expertise and vocabulary, and developing a deep understanding of mathematical models; (iii) acquainting participants with the challenges of collaboration and communication in interdisciplinary research, (iv) fostering community building, and (v) enhancing career development. Lecture materials (video-recorded), training datasets, and software tools will be made freely available through on-line distribution to maximize outreach. Course administration and logistics will be handled by the UC Irvine Center for Complex Biological Systems (CCBS), an NIH-designated National Center for Systems Biology.

我们提出了一项计划，以加强科学家的培训和职业发展，这些科学家寻求 开展跨学科的生物学和生物医学研究，借鉴来自以下领域的想法和工具 数学、物理、工程和计算机科学，如系统生物学这个年轻领域所体现的那样。 该项目以加州大学欧文分校为期三周的强化课程为中心，随后是一到两年的进修课程。 该课程面向研究生、博士后。 以及更先进的科学家，他们都有实验生物学背景，通常需要 数学和计算方面的额外准备——以及具有数学、物理、 工程学或计算机科学——通常需要在生物学基础上进行额外的准备。 目标是每年培训约20人。 拟议的计划首先是为期一周的预备研讨会，然后是为期两周的核心课程 其中讲座和实验室模块将使参与者接触最前沿的跨学科 该计划还将提供广泛的指导和职业技能建设。 活动，包括小组讨论、演示、指导团队项目和个人指导 这些活动将涉及 27 名 UCI 教员进行研究和研究。 数学、物理、计算机科学、工程和生物科学方面的教学专业知识。 外展活动包括通过在线资源和系统生物学传播信息 区域会议，以及参加跨学科和少数群体会议的研讨会。 该课程的具体目标包括（i）传达对系统生物学及其相关知识的理解。 跨学科性质；（ii）填补技术专业知识和词汇方面的空白，并发展深入的知识 了解数学模型；（iii）让参与者熟悉协作和 跨学科研究中的交流，(iv) 促进社区建设，以及 (v) 提升职业生涯 免费制作讲座材料（视频录制）、培训数据集和软件工具。 课程管理和后勤工作将通过在线分发进行。 由加州大学欧文分校复杂生物系统中心 (CCBS) 负责，该中心是 NIH 指定的国家中心 系统生物学。