Heritability of CP/CPPS and its Association with Posttraumatic Stress Disorder

CP/CPPS 的遗传性及其与创伤后应激障碍的关系

基本信息

批准号：
7928823
负责人：
Niloofar Afari
金额：
$ 9.7万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7928823
关键词：
Acute myocardial infarction Address Age Benign Prostatic Hypertrophy Cardiovascular Diseases Characteristics Chronic Prostatitis Clinical assessments Communities Congestive Heart Failure Consultations Data Data Element Databases Diabetes Mellitus Educational Status Environmental Risk Factor Epidemiologic Studies Epidemiology Etiology Event Fatigue Funding Future Genetic Habits Health Healthcare Heritability Hypertension Increased frequency of micturition Infection Inflammatory Bowel Diseases Knowledge Literature Low income Malignant neoplasm of prostate Mental disorders Myocardial Infarction Outpatients Pain Patient Self-Report Patients Pelvic Pain Pelvis Physiological Population Post-Traumatic Stress Disorders Prevalence Prostate Psyche structure Psychiatric Diagnosis Quality of life Recording of previous events Recruitment Activity Registries Reporting Research Research Personnel Research Priority Risk Risk Factors Role Sampling Social support Socioeconomic Status Staging Surveys Symptoms Syndrome Telephone Interviews Twin Multiple Birth Twin Studies Universities Vietnam Washington base chronic pain chronic pelvic pain cohort cooperative study depression design disability experience functional status genetic epidemiology health care service utilization interdisciplinary approach interest longitudinal course lower urinary tract symptoms male men nervous system disorder programs psychiatric disability psychologic psychosocial repository response self-reported functional status urologic

Acute myocardial infarction Address Age Benign Prostatic Hypertrophy Cardiovascular Diseases Characteristics Chronic Prostatitis Clinical assessments Communities Congestive Heart Failure Consultations Data Data Element Databases Diabetes Mellitus Educational Status Environmental Risk Factor Epidemiologic Studies Epidemiology Etiology Event Fatigue Funding Future Genetic Habits Health Healthcare Heritability Hypertension Increased frequency of micturition Infection Inflammatory Bowel Diseases Knowledge Literature Low income Malignant neoplasm of prostate Mental disorders Myocardial Infarction Outpatients Pain Patient Self-Report Patients Pelvic Pain Pelvis Physiological Population Post-Traumatic Stress Disorders Prevalence Prostate Psyche structure Psychiatric Diagnosis Quality of life Recording of previous events Recruitment Activity Registries Reporting Research Research Personnel Research Priority Risk Risk Factors Role Sampling Social support Socioeconomic Status Staging Surveys Symptoms Syndrome Telephone Interviews Twin Multiple Birth Twin Studies Universities Vietnam Washington base chronic pain chronic pelvic pain cohort cooperative study depression design disability experience functional status genetic epidemiology health care service utilization interdisciplinary approach interest longitudinal course lower urinary tract symptoms male men nervous system disorder programs psychiatric disability psychologic psychosocial repository response self-reported functional status urologic

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项目摘要

This study addresses the MAPP Research Network requirements for an epidemiological study and an examination of the genetic contributions to one of the conditions termed "urologic chronic pelvic pain syndromes" (UCPPS) by the MAPP initiative. Our objective in designing this project, and the University of Washington (UW) Discovery Center as a wholejs to enhance the growing body of knowledge about UCPPS by using a focused yet integrated multidisciplinary approach. Our approach will provide critical knowledge about the underlying genetic and environmental factors that promote CP/CPPS and its primary symptom of pain. One strength of this project is its response to multiple Research Priorities outlined in the MAPP RFA. Our primary aim is to determine the heritability of CP/CPPS by using genetic epidemiological strategies. A secondary aim is to address the phenotypic characteristics of CP/CPPS by examining current and historical demographic and psychosocial characteristics, psychiatric symptoms, and functional status. By identifying a cohort of middleaged twins with CP/CPPS, we also will set the stage for future projects that more comprehensively examine genetic and physiological factors in this cohort.

这项研究解决了流行病学研究的MAPP研究网络要求和检查对所谓的“泌尿科慢性骨盆疼痛”之一的遗传贡献 MAPP倡议的综合症（UCPPS）。我们设计该项目的目的华盛顿（UW）Discovery Center作为一个整体，以增强对UCPPS的知识的增长采用集中但集成的多学科方法。我们的方法将提供有关的批判知识促进CP/CPP及其主要疼痛症状的基本遗传和环境因素。一该项目的优势是它对MAPP RFA中概述的多个研究优先级的反应。我们的主要目的是通过使用遗传流行病学策略来确定CP/CPP的遗传力。第二个目标是通过检查当前和历史人口以及社会心理特征，精神病症状和功能状况。通过识别中间的队列带有CP/CPP的双胞胎，我们还将为未来的项目奠定舞台，以更全面地研究该队列中的遗传和生理因素。