Center for Adolescent Reward, Rhythms and Sleep (CARRS)

青少年奖赏、节奏和睡眠中心 (CARRS)

基本信息

批准号：
10217066
负责人：
Colleen A McClung
金额：
$ 293.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10217066
关键词：
Academy Adolescence Adolescent Adolescent Development Adult Affect American Animals Beds Biological Biology Brain Cells Centers of Research Excellence Child Chronic Circadian Rhythms Circadian desynchrony Clinical Cognition Communities Community Outreach Complement Data Development Discipline Drug abuse Education and Outreach Electronics Electrophysiology (science)Ensure Environmental Risk Factor Epidemic Funding Future Genetic Goals Grant Health Home environment Hormones Human Impulsivity Individual Institutes Intervention Jet Lag Syndrome Label Lead Life Style Methods Modeling Molecular Molecular Target National Institute of Drug Abuse Neurons Neurosciences Outcome Parents Pediatrics Phase Phenotype Pilot Projects Population Prevention strategy Process Psychiatry Puberty Public Health Rattus Recording of previous events Reproducibility Research Research Personnel Research Training Resources Rewards Risk Risk-Taking Rodent Role Schools Scientist Site Sleep Sleep Deprivation Sleep disturbances Social Interaction Students Substance Use Disorder Substance abuse problem Synapses System Teenagers Testing Therapeutic Intervention Time Time Factors Training Training Programs Training and Education Translational Research United States Universities Variant Work addiction adolescent brain development biobank circadian cognitive control cortico-limbic circuits cost effectiveness data management experience high school human study innovation junior high school neuronal circuitry novel peer preference prevent response reward circuitry social social factors statistics substance use teacher therapeutic development therapy development time use trait young adult

项目摘要

PROJECT SUMMARY We are proposing a NIDA Research Center of Excellence (P50) entitled, Center for Adolescent Reward, Rhythms and Sleep (CARRS). Adolescence is a vulnerable time for substance abuse. This risk reflects the heightened reward system of adolescence, which is found regardless of cultural upbringing or home environment, relative to both adults and children. In addition, genetic, social and environmental factors influence the amount of sleep and circadian rhythm misalignment experienced by the adolescent brain. The goal of CARRS is to integrate human and rodent studies to understand the impact of adolescent sleep and circadian rhythm changes (both biologically and environmentally induced) on reward circuitry and substance use (SU)- relevant outcomes. We will use experimental manipulations to further examine how sleep and circadian rhythms affect reward function and SU-related outcomes, with the ultimate goal of developing novel prevention or intervention strategies. Late sleep timing, short sleep duration and circadian misalignment are associated with increased substance use in teenagers and young adults. The central hypothesis of the Center is that adolescent development acts on underlying sleep and circadian traits to modify homeostatic sleep drive, circadian phase, and circadian alignment, which in turn impact cortico-limbic functions critical to substance use risk (e.g., reward and cognitive control). We further hypothesize that specific manipulations of sleep and circadian rhythms during adolescence will affect reward responsivity and cognitive control in either positive or negative directions. These manipulations will provide experimental support for our model, and proof of concept for novel clinical interventions to reduce the risk of substance use disorders. In turn, abuse of drugs will also impact the circadian, reward and sleep systems, creating a vicious cycle. Interventions that help stabilize the circadian and sleep systems, or reduce the damage done by these disruptions, may be protective against substance abuse in vulnerable individuals. The goals of the center are to 1) Determine the role of sleep and circadian rhythms in reward sensitivity and substance use (SU) in adolescence. 2) Conduct translational research aimed at the development of interventions to reduce risk in at-risk individuals. 3) Partner with other Centers and the addiction research community to inform and complement ongoing research. 4) Provide training and education on sleep, circadian rhythms, and substance use.

项目概要我们提议建立一个 NIDA 卓越研究中心 (P50)，名为“青少年奖励中心”，节律和睡眠（CARRS）。青春期是药物滥用的脆弱时期。这种风险反映了青春期强化奖励制度，无论文化背景或家庭背景如何环境，无论是成人还是儿童。此外，遗传、社会和环境因素也会影响青少年大脑经历的睡眠量和昼夜节律失调。目标是 CARRS 将整合人类和啮齿动物研究，以了解青少年睡眠和昼夜节律的影响奖赏回路和物质使用 (SU) 的节律变化（生物和环境引起的）- 相关成果。我们将使用实验操作来进一步检查睡眠和昼夜节律如何影响奖励功能和 SU 相关结果，最终目标是开发新的预防或干预策略。睡眠时间晚、睡眠时间短和昼夜节律失调与青少年和年轻人的物质使用增加。该中心的中心假设是青少年发育作用于潜在的睡眠和昼夜节律特征，以改变稳态睡眠驱动、昼夜节律阶段，和昼夜节律调整，这反过来又影响对药物使用风险至关重要的皮质边缘功能（例如，奖励和认知控制）。我们进一步假设，在睡眠期间对睡眠和昼夜节律的特定控制青春期会以积极或消极的方式影响奖赏反应和认知控制。这些操作将为我们的模型提供实验支持，并为新型临床提供概念证明降低物质使用障碍风险的干预措施。反过来，滥用药物也会影响昼夜节律，奖励和睡眠系统，形成恶性循环。有助于稳定昼夜节律和睡眠的干预措施系统，或减少这些中断造成的损害，可能有助于防止药物滥用弱势个体。该中心的目标是 1) 确定睡眠和昼夜节律在青春期的奖励敏感性和物质使用（SU）。 2) 开展转化研究制定干预措施以降低高危人群的风险。 3）与其他中心和成瘾合作研究界为正在进行的研究提供信息和补充。 4）提供睡眠方面的培训和教育，昼夜节律和物质使用。