Mental Retardation and Developmental Disabilities Research Centers 2008

精神发育迟滞和发育障碍研究中心 2008 年

• 批准号: 7670295
• 负责人: MICHAEL F CATALDO
• 金额: $ 127.84万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7670295
• 关键词: Mental; Retardation; Developmental; Disabilities; Research

DESCRIPTION (provided by applicant): This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-07-012. The MRDDRC consists of the Administrative Core (Core A) with four subdivisions, and four research cores (Cores B, C, D, and E). Core A (Administrative), provides overall leadership, management, and organizational support to the Center, operates the educational component (lectures and seminars), links users to biostatistical services (a research subdivision), assists with preparation of IRB materials, monitors issues of human research protection, and develops participant registries. Core B (Genetics) provides centralized tissue culture, amino acid/organic acid analyses, standard and molecular cytogenetics, specialized molecular genetics (DNA and RNA analyses) microarrarys and bioinformatics. Core C (Neuroscience) provides synaptic neurochemistry (focusing on histology imaging and high performance liquid chromatography) and lipid biochemistry (lipid metabolism, fatty acid analysis, and mass spectrometry services). Core D (Neuroimaging) provides for acquisition and quantitative analysis of data derived from functional, volumetic, diffusion tensor, and spectroscopic MR imaging. Core E (Behavior Science) offers training of subjects for cooperation with research protocols, selection and administration of standardized tests (developmental, cognitive, and functional), direct observations of behavior, design of activation paradigms for fMRI, and motion analysis (e.g., quantitative computer-assisted methods of documenting gaits, reaching, and learning behaviors within the motor domain). The core units serve 156 projects representing current direct annual NIH support totaling over $104 million dollars. The program addresses 30 of the 31 priority areas set forth in the RFA-HD-07-012, featuring interdisciplinary collaboration and a central theme, brain mechanisms whereby genotypes result in specific cognitive and behavioral phenotypes of mental retardation or developmental disability.

描述（由申请人提供）：肯尼迪·克里格研究所（Kennedy Krieger Institute）和约翰·霍普金斯大学（Johns Hopkins University）的持续支持21年至25年的申请支持RFA-HD-HD-07-012。 MRDDRC由具有四个细分的行政核心（核心A）和四个研究核心（核B，C，D和E）组成。 核心A（行政）为中心提供总体领导，管理和组织支持，运营教育组成部分（讲座和研讨会），将用户与生物统计学服务（研究细分）联系起来，有助于准备IRB材料，监视人类研究保护的问题，并开发参与者注册。 核B（遗传学）提供集中的组织培养，氨基酸/有机酸分析，标准和分子细胞遗传学，专业的分子遗传学（DNA和RNA分析）微倒立和生物信息学。 Core C（神经科学）提供突触神经化学（侧重于组织学成像和高性能液相色谱）和脂质生物化学（脂质代谢，脂肪酸分析和质谱服务）。 核心D（神经影像学）提供了对源自功能，体积，扩散张量和光谱MR成像的数据的获取和定量分析。 核心E（行为科学）提供了与研究协议，标准化测试（发展，认知和功能）合作的主题培训，直接观察fMRI的激活范例的设计以及运动分析（例如，定量计算机辅助的方法可以记录Gaits，与Motory domain domain domain）。 核心单位为156个项目提供服务，代表当前直接年度NIH支持，总计超过1.04亿美元。 该计划介绍了RFA-HD-07-012中提出的31个优先领域中的30个，该领域具有跨学科的合作和中心主题，大脑机制，基因型会导致特定的认知和行为智能表型或发育障碍。