Vitamin D Status and Incident Type 2 Diabetes

维生素 D 状况和 2 型糖尿病事件

• 批准号: 7492213
• 负责人: Anastassios G Pittas
• 金额: $ 23.09万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7492213
• 关键词: Adult; Age; Ancillary Study; Animals; Area; Award; Blood; Body Weight decreased; C-reactive protein; Calcium; Caring; Case-Control Studies; Clinical; Clinical Research; Cross-Sectional Studies; Data; Data Analyses; Data Set; Development; Diabetes Mellitus; Diagnosis; Dietary Intervention; Disease; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Fasting; Foundations; Future; Goals; Homeostasis; Incidence; Individual; Inflammation; Insulin; Intake; Interleukin-6; Intervention; Kidney Diseases; Knowledge; Lead; Measures; Mediating; Medical; Modality; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Nurses' Health Study; Nutritional; Obesity; Observational Study; Outcome; Plasma; Population; Prevention; Prevention intervention; Preventive; Randomized Controlled Clinical Trials; Range; Rate; Receptors, Tumor Necrosis Factor, Type II; Research; Research Design; Risk; Risk Factors; Seasons; Serum; TNF gene; Techniques; Testing; Therapeutic; Vitamin D; Weight; Woman; Work; base; clinical effect; cohort; cost; design; diabetes risk; expectation; falls; human study; innovation; insulin sensitivity; novel; prevent; prospective

DESCRIPTION (provided by applicant): The incidence of type 2 diabetes mellitus is increasing at an alarming rate both nationally and worldwide with more than 1 million new cases per year diagnosed in the US alone. Although weight-loss has been shown to be successful in delaying diabetes, it is difficult to achieve and maintain long-term. Therefore, identification of weight-independent environmental and easily modified risk factors is urgently needed to prevent the increase in the incidence of type 2 diabetes. Vitamin D is a nutritional factor that has been suspected as a modifier of diabetes risk based on animal and human studies including our own preliminary observational data. However, there are critical gaps in our knowledge about the magnitude of the clinical effect of vitamin D on diabetes risk. Currently, this lack of data limits the usefulness of vitamin D as a feasible nutritional intervention for prevention of type 2 diabetes. The central hypothesis of the proposed study is that, vitamin D insufficiency is a risk factor for the development of type 2 diabetes. We plan to test our main hypothesis and accomplish the objectives of this application by pursuing an ancillary study to an ongoing observational study to assess the magnitude of the association between vitamin D status and risk of developing type 2 diabetes. The working hypothesis is that vitamin D status, as measured by serum 25OHD level, is inversely associated with type 2 diabetes risk. The association will be quantified in a nested case-control study design in healthy women in a large prospective cohort, the Nurses' Health Study (600 t2DM cases and 600 controls - matched by age and season of blood draw). We will adjust for potential diabetes confounders (demographic, medical and nutritional) that have been measured and we will also examine whether the association is modified by BMI or calcium intake.

描述（由申请人提供）：2型糖尿病的发病率在全国和全球范围内以惊人的速度增加，仅在美国就被诊断出了超过100万个新病例。尽管减肥已被证明在延迟糖尿病方面取得了成功，但很难实现和维持长期。因此，迫切需要确定不依赖重量的环境和易于改变的风险因素，以防止2型糖尿病的发生率增加。维生素D是一种营养因素，基于动物和人类研究，包括我们自己的初步观察数据，被怀疑是糖尿病风险的修饰剂。但是，关于维生素D对糖尿病风险的临床作用的大小，我们的知识存在关键的差距。目前，缺乏数据限制了维生素D作为可行的营养干预措施来预防2型糖尿病。拟议的研究的中心假设是，维生素D功能不全是2型糖尿病发展的危险因素。我们计划通过对正在进行的观察性研究进行辅助研究来评估维生素D状态与患上2型糖尿病风险之间的关联幅度，以测试我们的主要假设并实现本应用的目标。工作假设是，通过血清25OHD水平衡量的维生素D状态与2型糖尿病风险成反比。该关联将在健康女性的嵌套病例对照研究中进行量化，该研究在一个大型的前瞻性队列中，护士健康研究（600 T2M病例和600个对照组 - 按年龄和抽血的年龄和季节匹配）。我们将调整已测量的潜在糖尿病混杂因素（人口统计，医学和营养），我们还将检查该关联是否通过BMI或钙摄入进行了修改。