ADOLESCENT ANXIETY: A LONGITUDINAL TWIN STUDY PERSPECTIVE

青少年焦虑：纵向双胞胎研究的视角

• 批准号: 7628813
• 负责人: Harold Hill Goldsmith
• 金额: $ 29.51万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7628813
• 关键词: Adolescence; Adolescent; Affective; Age; Anxiety; Anxiety Disorders; Behavior; Behavioral; Biometry; Birth; Birth Records; Bone callus; Categories; Child; Childhood; Class; Classification; Clinical; Cognitive; Comorbidity; DSM-IV; Data; Depressed mood; Diagnosis; Diagnostic; Dimensions; Family; Foundations; Functional Magnetic Resonance Imaging; Gene Family; Genetic; Genetic Variation; Growth; Heritability; Heterogeneity; Hydrocortisone; Image; Individual; Interview; Laboratories; Linear Regressions; Magnetic Resonance Imaging; Measures; Mental Depression; Methods; Modeling; Mothers; Multivariate Analysis; Neurosecretory Systems; Pattern; Performance; Phenotype; Pregnancy; Principal Investigator; Problem behavior; Process; Protocols documentation; Psychopathology; Qualifying; Reaction Time; Risk Factors; Sampling; Sampling Studies; Specific qualifier value; Stress; Structure; Subgroup; Telephone Interviews; Temperament; Testing; Trier Social Stress Test; Twin Multiple Birth; Twin Studies; base; childhood anxiety; disease classification; follow-up; hypothalamic pituitary axis; improved; neuroimaging; programs; relating to nervous system; sex

Project 3 seeks to understand the longitudinal pattern of behavioral problems in twin children by following up a sample previously systematically ascertained from birth records. The project uses genetic latent class analysis applied to 3-occasion, longitudinal data (age 7-8 years, 12-13 years, and 15-16 years) as a foundation for understanding temperamental and family risk factors, as well as to provide a sample for studying neural correlates of adolescent anxiety in Project 4. We predict that the child's standing on a profile of seven dimensions (depressed, socially anxious, worried/obsessive, inattentive, impulsive, hyperactive, defiant/aggressive/callous) assessed with multiple methods will reveal heterogeneity within existing DSM-IV diagnostic categories and commonality among subgroups of children with different DSM-IV diagnoses. Several risk factors will be examined within the context of latent growth curve analysis, including basal and reactive cortisol patterns studied longitudinally, allelic variants of 8 genes, family stress and observed family interaction patterns, pregnancy and birth complications, and childhood temperament. Operationally, the project involves conducting telephone interviews of both twins and their mothers for a sample over 1,200 twins and their mothers, extensive statistical analyses of the longitudinal data, and a laboratory-based assessment of a subsample who qualify for a diagnosis of anxiety disorder or depression. The laboratory-based assessment battery will include a structured psychiatric interview, cognitive/affective assessments (reaction time and other performance-based measures), and the Trier Social Stress Test as protocol to activate the HPA axis. Results should improve understanding of (1) nosology of childhood anxiety problems; (2) how risk factors act over a substantial period of childhood and adolescence; and (3) cognitive and other processes that may form the substrate of anxious behavior.

项目3试图通过跟进双胞胎儿童的行为问题的纵向模式 先前从出生记录中系统地确定的样本。该项目使用遗传潜伏类 分析适用于3次锻造，纵向数据（年龄7-8岁，12-13岁和15-16岁） 理解气质和家庭风险因素的基础，并为 研究项目4中的青春期焦虑的神经相关性。我们预测孩子站在个人资料上 在七个维度（沮丧，社交焦虑，忧虑，不专心，冲动，多动，多动， 使用多种方法评估的反抗/积极/冷酷）将揭示现有DSM-IV中的异质性 具有不同DSM-IV诊断的儿童亚组之间的诊断类别和共同点。 将在潜在的增长曲线分析的背景下检查几个危险因素，包括基础和 纵向研究的反应性皮质醇模式，8种基因的等位基因变体，家族应力和观察到的家族 相互作用模式，怀孕和出生并发症以及童年的气质。 在操作上，该项目涉及对双胞胎及其母亲进行电话采访 样本超过1,200个双胞胎及其母亲，对纵向数据的广泛统计分析，A 基于实验室的评估子样本有资格诊断焦虑症或抑郁症。 基于实验室的评估电池将包括结构化的精神访谈，认知/情感 评估（反应时间和其他基于绩效的措施），以及Trier社会压力测试 激活HPA轴的协议。 结果应提高对（1）儿童焦虑问题的疾病的理解； （2）风险因素如何行为 在大量的童年和青春期； （3）可能形成的认知和其他过程 焦虑行为的基材。