STRESS EXPOSURE, HPA ACTIVITY AND RISK FOR ADOLESCENT INTERNALIZING DISORDERS

压力暴露、HPA 活动和青少年内化障碍的风险

• 批准号: 7628811
• 负责人: Marilyn J Essex
• 金额: $ 29.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7628811
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Age; Amygdaloid structure; Anisotropy; Behavioral; Birth; Child; Childhood; Clinical; Clinical assessments; Communities; Comorbidity; Data; Data Set; Development; Diagnostic; Disease; Emotions; Family Study; Functional Magnetic Resonance Imaging; Funding; HPSE gene; Hydrocortisone; Impairment; Individual; Interview; Laboratories; Life; Maintenance; Mental Health; Mothers; Nature; Prefrontal Cortex; Principal Investigator; Psychopathology; Recording of previous events; Recovery; Reporting; Research; Research Personnel; Risk; Role; Salivary; Sampling; Sex Characteristics; Stress; Stress Tests; Symptoms; System; Telephone; Trier Social Stress Test; Wisconsin; Work; base; biological adaptation to stress; cohort; emotion regulation; experience; hypothalamic-pituitary-adrenal axis; infancy; innovation; neural circuit; neuroimaging; novel; prenatal; programs; relating to nervous system; stressor; teenage mother; white matter

Adolescence is a period of rapid change, marked by increased stress and emotion regulation difficulties, and concomitant increases in stress-related psychopathology. Although much research has been devoted to understanding the role of stress response systems, especially the HPA axis, in the development and maintenance of internalizing disorders, very little research has focused on the vulnerable adolescent period and none has been conducted prospectively beginning in infancy. Over the past 17 years, a large cohort of children participating since birth in the Wisconsin Study of Family and Work has been intensively studied to examine longitudinal associations of early stress exposure, HPA activity, and the development of childhood mental health problems. Based on these unique developmental data, the present proposal affords an unprecedented opportunity to follow this sample through adolescence, addressing novel questions regarding the role of early stress exposure in the sensitization of the HPA axis to later stress, associations with neural correlates of emotion dysregulation, and the development and course of internalizing psychopathology during this vulnerable period. To extend the existing longitudinal dataset to late adolescence, 300 adolescents and their mothers will be interviewed in grade 12 (approximate age 18). In addition, a,subset of 120 adolescents - selected on high vs. low early (age 41/¿) and later (ages 11,13 and 15) cortisol levels - will participate in an intensive laboratory assessment of HPA reactivity and, as part of Projects 4 and 5, neural bases of emotion regulation. Major aims are 1) to investigate the stress sensitization hypothesis in a community sample experiencing the normative stressors of adolescence; 2) to test the stress sensitization hypothesis in a formal laboratory paradigm (the Trier Social Stress Test) with high salience for adolescents; and 3) to identify the stress exposure, HPA, other stress reactivity, and neural circuitry factors, and their combinations, which best discriminate individuals with internalizing disorders by late adolescence. Relevance: This work is highly innovative, integrating the strengths of longitudinal field research with those of laboratory approaches to understand the development of the HPA stress response system and the neural circuitry implicated in adolescent vulnerability to develop stress-related psychopathology, thus providing much needed information for researchers, clinicians, and policymakers.

青春期是一个快速变化的时期，以增加压力和情绪调节困难的增加，以及 与压力相关的心理病理学的同时增加。尽管已经致力于 了解压力响应系统，尤其是HPA轴，在开发中的作用 维持内在疾病，很少的研究集中在脆弱的青少年时期 并且没有一个从婴儿期开始进行的。在过去的17年中，一大批 自从出生以来，儿童参加了威斯康星州的家庭和工作研究，一直在研究 检查早期压力暴露，HPA活性和童年发展的纵向关联 心理健康问题。基于这些独特的发展数据，本提案提供了一个 前所未有的机会，可以通过青少年遵循该样本，解决有关 早期应力暴露在HPA轴对后期压力的敏感性中的作用，与中性的关联 情绪失调的相关性以及内在精神病理学的发展和过程 在这个脆弱的时期。为了将现有的纵向数据集扩展到后期的青春期晚期，300 青少年及其母亲将在12年级（大约18岁）接受采访。另外，一个子集 120名青少年 - 在高早期（年龄41/€）和更高的（11,13和15岁）皮质醇水平上选出 - 选择 - 将参加HPA反应性的密集实验室评估，作为项目4和5的一部分 情绪调节的神经基础。主要目的是1）研究应力敏感性假设 社区样本经历青少年正常压力源； 2）测试应力敏感性 正式的实验室范式（Trier社会压力测试）中的假设具有很高的显着性； 3）确定压力暴露，HPA，其他压力反应性和神经回路因子及其 组合，最能通过青少年晚期来区分患有内在疾病的人。 相关性：这项工作具有很高的创新性，将纵向现场研究的优势与之相结合 实验室方法了解HPA应力响应系统的发展和中性 在青少年脆弱性中实施的电路，以发展与压力相关的心理病理学，从而提供 研究人员，临床医生和政策制定者急需的信息。