The Role of Food Insecurity and Sensitization in Excess Weight Gain in Adolescents from Low to Moderate Income Households

粮食不安全和敏感性在低收入和中等收入家庭青少年体重过度增加中的作用

• 批准号: 10387806
• 负责人: Jennifer L Temple
• 金额: $ 66.34万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10387806
• 关键词: 3-Dimensional; Adolescent; Adult; Behavioral; Body Weight Changes; Body mass index; Cardiovascular system; Caregivers; Child; Chronic Disease; Communities; Complex; Consumption; Data; Development; Eating; Education; Effectiveness; Energy Intake; Enrollment; Environmental Risk Factor; Etiology; Family dynamics; Food; Food Access; Goals; Healthy Eating; Home; Household; Income; Individual; Intake; Intervention; Longevity; Low income; Mediating; Neighborhoods; Nutritional; Obesity; Occupations; Overweight; Palate; Parents; Perception; Periodicity; Phenotype; Play; Population; Prevention strategy; Public Health; Reporting; Research; Role; Sampling; Secure; Self Efficacy; Socioeconomic Status; Testing; Time; Weight; Weight Gain; Work; behavioral phenotyping; behavioral study; cohort; discounting; disorder risk; energy density; ethnic minority population; evidence base; excessive weight gain; experience; feeding; food environment; food insecurity; food resource; food security; high risk; high risk population; individualized medicine; lower income families; member; novel; obesity prevention; parental influence; perceived stress; prospective; racial and ethnic; racial minority; social; social determinants; social health determinants; treatment strategy

Abstract: The etiology of obesity is complex and is driven by different factors in different populations, including across developmental stages, in different racial and ethnic communities, and at different levels of socioeconomic status (SES). It is important to identify the factors that promote excess energy intake in the highest risk populations to develop evidence-based, effective obesity prevention and treatment strategies. Over the past decade, it has become apparent that studying behavioral phenotypes that predict overweight, obesity, and weight change across the lifespan is critical for developing individualized intervention strategies with a high degree of efficacy and effectiveness. One novel phenotype that has been identified and characterized is sensitization of the relative reinforcing value (RRV) of food. This is defined as an increase in the RRV of a food after repeated, daily consumption of high energy density (HED) food for two weeks. In adults, sensitization is positively associated with BMI and prospectively predicts weight gain over time. The cross-sectional relationship between zBMI and sensitization has been replicated in a cohort of adolescents enrolled in the UBSNAK study and recent data have shown that, as in adults, sensitization prospectively predicts zBMI change in adolescents. It is also known, from preliminary work, that the relationship between food insecurity and zBMI is associated with other individual, behavioral, and environmental factors, such as delay discounting, perceived stress, and self-efficacy for healthy eating. The goals of the proposed study are 1) to investigate the relationship between food insecurity and sensitization 2) to determine the role of sensitization in determining zBMI and zBMI change in a population of moderate to low-income adolescents and 3) to determine how adolescent food insecurity interacts with household food insecurity to moderate the relationship between sensitization and zBMI change. The first aim will test the hypothesis that food insecurity is related to sensitization and that this relationship is mediated by individual, behavioral, and environmental factors. The second aim will test the hypothesis that household food insecurity moderates the relationship between sensitization and zBMI change over time in adolescents. The third aim will test the hypothesis that adolescent food insecurity interacts with household food insecurity to moderate the relationship between sensitization and zBMI change and that one factor that impacts this relationship is adolescent eating autonomy. When taken together, this study will help to identify and characterize novel intervention targets in a population of adolescents at higher risk for overweight and obesity.

摘要： 肥胖的病因复杂，不同人群受不同因素影响， 包括不同的发展阶段、不同的种族和族裔社区以及不同的发展水平 社会经济地位（SES）。重要的是要确定促进体内能量摄入过多的因素。 最高风险人群制定基于证据的、有效的肥胖预防和治疗策略。 在过去的十年中，很明显，研究预测超重的行为表型， 肥胖和整个生命周期的体重变化对于制定个性化干预策略至关重要 具有高度的功效和效果。已鉴定出一种新的表型 其特征是食物的相对强化值（RRV）的敏化。这被定义为增加 连续两周每天重复食用高能量密度 (HED) 食物后食物的 RRV。在 对于成年人来说，敏化与 BMI 呈正相关，并且可以前瞻性地预测体重随时间的增加。这 zBMI 与敏化之间的横截面关系已在青少年队列中得到复制 参加了 UBSNAK 研究，最近的数据表明，与成人一样，前瞻性敏化 预测青少年 zBMI 变化。从初步工作中还知道，之间的关系 粮食不安全和 zBMI 与其他个人、行为和环境因素相关，例如 延迟折扣、感知压力和健康饮食的自我效能。拟议研究的目标是 1) 调查粮食不安全与过敏之间的关系 2) 确定 确定中低收入青少年群体 zBMI 和 zBMI 变化的敏感性 3) 确定青少年粮食不安全如何与家庭粮食不安全相互作用，以缓解 敏化与 zBMI 变化之间的关系。第一个目标将检验粮食不安全的假设 与敏化有关，这种关系是由个人、行为和环境介导的 因素。第二个目标将检验家庭粮食不安全会缓和这种关系的假设 青少年的敏化和 zBMI 之间的关系随着时间的推移而变化。第三个目标将检验以下假设： 青少年粮食不安全与家庭粮食不安全相互作用，以调节两者之间的关系 敏感度和 zBMI 发生变化，影响这种关系的一个因素是青少年饮食 自治。综合起来，这项研究将有助于确定和描述新的干预目标 超重和肥胖风险较高的青少年群体。