Neural Mechanisms Underlying MBSR in Socially Phobic Individuals

社交恐惧症患者 MBSR 背后的神经机制

基本信息

批准号：
7661349
负责人：
JAMES J GROSS
金额：
$ 19.17万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2010-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this proposal is to identify the neural mechanisms underlying changes associated with Mindfulness-Based Stress Reduction (MBSR). Clinical research has shown that MBSR reduces psychological distress and increases well-being, but the mechanisms underlying these changes in not well described. Basic research has examined the neural bases of emotion and emotion regulation, but this research has not examined changes following MBSR. To integrate clinical and basic research literatures, we employ a translational framework that characterizes the impact of MBSR on emotion regulation in terms of interactions between ventral emotion-generative brain regions and dorsal emotion-regulatory brain regions. Within this framework, we propose to compare the effects of MBSR and an active control condition (ACC) in participants with generalized social phobia (SP). SP will be randomly assigned to MBSR or ACC and assessed using self-report inventories and functional magnetic resonance imaging (fMRI) before and after MBSR and the ACC. Three aims will be investigated: Aim 1 investigates the effects of MBSR on anxiety and well-being. For the MBSR participants, we expect significant (a) decreases in anxiety, and (b) increases in well-being at immediately post-intervention and at the 3-month follow-up compared to pre-intervention. For the ACC participants, we expect no change in anxiety or well-being from pre- to post-intervention. Aim 2 investigates the effects of MBSR on attentional and cognitive emotion regulation. We expect MBSR participants to show improvements in attentional regulation (the focus of MBSR), but no change in cognitive regulation (not the focus of MBSR) from pre- to post-intervention, as indicated by (a) greater reductions in negative emotion ratings, (b) greater reductions in ventral emotion-generative brain regions, as well as (c) greater increases in attention-related dorsal emotion-regulatory brain regions. We do not expect ACC participants to show changes in either form of regulation from pre- to post-ACC. Aim 3 investigates whether MBSR-related changes in attentional emotion regulation mediate MBSR treatment response (decreases in anxiety and increases in well-being) at post-treatment and at the 3-month follow-up.

描述（由申请人提供）：该提案的总体目标是确定与基于正念的压力减轻（MBSR）相关的神经机制。临床研究表明，MBSR减少了心理困扰并增加了幸福感，但是这些变化的机制却没有很好地描述。基础研究检查了情绪和情感调节的神经基础，但是这项研究尚未检查MBSR后的变化。为了整合临床和基础研究文献，我们采用了一个翻译框架在腹侧情绪产生大脑区域和背部情绪调节大脑区域之间的相互作用方面，MBSR对情绪调节的影响。在此框架内，我们建议比较MBSR的影响和积极的控制条件（ACC）对具有广义社会恐惧症（SP）的参与者的影响。 SP将随机分配给MBSR或ACC，并在MBSR和ACC之前使用自我报告清单和功能磁共振成像（fMRI）进行评估。将研究三个目标：AIM 1研究MBSR对焦虑和福祉的影响。对于MBSR参与者，我们预计焦虑症的显着（a）会显着减少，并且（b）在干预后立即和3个月的随访时（b）增加了福祉，与干预前相比。对于ACC参与者，我们预计从干预前到干预后的焦虑或福祉不会改变。 AIM 2研究了MBSR对注意力和认知情绪调节的影响。我们期望 MBSR参与者表现出注意力调节的改善（MBSR的重点），但在干预前到干预后的认知调节（不是MBSR的重点）没有变化，如（a）负面情绪评级的降低，（b）更大的腹部情绪生成大脑区域的降低较大，以及较大的脑部脑部的减少（C）较大的脑部（C）提高了（C）提高（C）的注意力（c）引起了人们的注意力（无异常）。我们不希望ACC参与者以ACC前到ACC的两种形式的法规形式显示变化。 AIM 3调查了与MBSR相关的注意情绪调节的变化是否介导MBSR治疗反应（减少焦虑和健康状况增加）和在3个月的随访中。