Emergence of SIB in Developmentally Delayed Individuals

发育迟缓个体中 SIB 的出现

• 批准号: 7581084
• 负责人: CURT ALAN SANDMAN
• 金额: $ 47.92万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-20 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7581084
• 关键词: Address; Adrenal Glands; Affect; Behavior; Behavioral; Biological; Biological Factors; Blood; Chronic; Computer Assisted; Critiques; Data; Dependence; Dependency; Dimensions; Environment; Equilibrium; Evaluation; Event; Exhibits; Frequencies; Genetic; Hydrocortisone; Hypothalamic structure; Individual; Laboratories; Life; Living Arrangement; Longevity; Maintenance; Measures; Mentally Disabled Persons; Methods; Motivation; Naltrexone; Outcome; Pattern; Pharmacological Treatment; Phenotype; Pituitary Gland; Population; Predisposition; Probability; Procedures; Recording of previous events; Regulation; Reporting; Residential Facilities; Self-Injurious Behavior; Sleep; Staging; Stress; System; Testing; Time; Time Series Analysis; Validation; base; behavior change; cohort; endogenous opioids; environmental change; improved; in vivo; injured; novel; premature; response

Self-injuring behavior (SIB) surprisingly prevalent among neurodevelopmentally delayed and mentally retarded individuals, has no known cause and no agreed upon treatment. Expression of SIB may persist throughout the lifespan and into later stages of life, with little change in frequency or quality. Two distinct patterns of SIB have been proposed. One pattern consists of short bouts that may be maintained by environmental contingencies. A second pattern involves protracted periods of SIB that probably is motivated by biological factors. Recent studies from our laboratory indicated that self-injuring behavior was predicted best (and in some cases only) by its own recent history. In a significant majority of individuals, SIB episodes were self-perpetuating and not related to antecedent conditions. We report in this application that individuals exhibiting "contagious" (i.e. sequentially dependent) patterns of SIB also have a disregulated hypothalamic- pituitary-adrenal (HPA) stress axis. We have concluded that there is both a biological predisposition to, and a biological consequence for, the maintenance of SIB. These conclusions may be premature and a more extensive evaluation of the environmental context is warranted. Moreover, there are no data about what initiates a contagious cycle. The purpose of this proposal is to examine the behavioral, environmental and biological circumstances that initiate and maintain SIB episodes. Thirty individuals exhibiting SIB and thirty control subjects, all residing in a large residential facility will be observed in vivo and during an experimental functional analysis of behavior (FAB). Their behavior, interactions and the environmental conditions will be recorded with computer-assisted procedures. Blood will be collected for measures of HPA activity in the morning on a separate day. The Specific Aims are: (i) Determine how the patterns of SIB are affected by environmental context in both in vivo and FAB conditions using sequentially- and temporally-dependent time series analysis, (ii) Determine if there are consistent patterns of environmental events or relations among behaviors that are antecedent to the first or isolated SIB episodes; (Hi)Determine the relation between the HPA stress axis the initiation of SIB, (iv) Apply and evaluate a rational pharmacological treatment to a selected cohort of subjects who present clear evidence of biological (or internal) motivation for SIB. Findings from this project will contribute to the understanding of the emergence and maintenance of SIB.

自我伤害行为（SIB）在神经发育延迟和精神上令人惊讶 智障人士，没有已知原因，也没有同意治疗。 SIB的表达可能会持续 在整个生命周期内到生命的后期阶段，频率或质量几乎没有变化。两个不同的 已经提出了SIB模式。一种模式由可能由 环境突发事件。第二种模式涉及可能是动机的SIB的旷日持久时期 由生物因素。我们实验室的最新研究表明，预测了自我伤害行为 最好的（在某些情况下仅在某些情况下）截至其自己的近期历史。在绝大多数人中，SIB发作 是自我延续的，与先决条件无关。我们在此申请中报告个人 表现出“传染性”（即顺序依赖）的SIB模式，也没有下丘脑 垂体 - 肾上腺（HPA）应力轴。我们得出的结论是，对 维持SIB的生物学后果。这些结论可能还为时过早，还有更多 有必要对环境环境进行广泛的评估。而且，没有关于什么的数据 启动一个传染性周期。该提案的目的是检查行为，环境和 启动和维护SIB发作的生物环境。三十个人表现出同胞和三十个人 控制对象，所有居住在大型住宅设施中的控制受试者将在体内和实验中观察到 行为的功能分析（FAB）。他们的行为，互动和环境条件将是 用计算机辅助的程序记录。将收集血液，以衡量HPA活性 在不同的一天的早晨。具体目的是：（i）确定SIB的模式如何受到 在体内和FAB条件下使用顺序依赖和时间依赖的时间的环境环境 系列分析，（ii）确定环境事件的一致模式或关系 与第一个或孤立的SIB发作的前提行为； （hi）确定 HPA应力轴的启动SIB的启动，（IV）应用并评估合理的药理学治疗 选定的受试者列出了SIB生物（或内部）动机的明确证据。发现 该项目将有助于理解SIB的出现和维护。