Listening effort under auditory masking conditions in persons with acquired aphasia

获得性失语症患者在听觉掩蔽条件下的听力努力

• 批准号: 10208854
• 负责人: Sarah Noelle Villard
• 金额: $ 8.96万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-03 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208854
• 关键词: Acoustics; Acquired Aphasia; Address; Affect; Age; Aphasia; Area; Auditory; Brain; Chronic; Cognitive; Communication; Communication impairment; Communities; Community Participation; Complex; Comprehension; Data; Development; Electroencephalography; Environment; Exhibits; Expenditure; Family; Fatigue; Goals; Hearing; Impairment; Individual; Investigation; Language; Language Disorders; Lead; Lesion; Linguistics; Location; Magnetic Resonance Imaging; Masks; Measures; Mentors; Methodology; Mission; National Institute on Deafness and Other Communication Disorders; Outcome; Patient Self-Report; Performance; Persons; Phase; Population; Psychoacoustics; Pupil; Quality of life; Rehabilitation therapy; Reporting; Research; Resources; Restaurants; Scientist; Short-Term Memory; Signal Transduction; Source; Speech; Stress; Stroke; Structure; Training; Treatment outcome; United States; Work; age related; career; chronic stroke; clinically relevant; experience; hearing impairment; indexing; negative affect; operation; perceived stress; skills; social; social engagement; social implication; sound; speech processing; speech recognition; stroke-induced aphasia; tool

Project Summary/Abstract Aphasia is a common consequence of stroke, affecting approximately 1 million individuals in the United States and often persisting as a chronic condition. A growing body of work suggests that persons with chronic aphasia (PWA) are poorer than age- and hearing-matched controls at understanding speech when background sounds, or auditory maskers, are present. However, little is currently known about how auditory masking affects listening effort in PWA. Listening effort—that is, the cognitive resources directed towards decoding an auditory signal—is a key construct in the study of receptive speech processing. The presence of auditory maskers can often result in substantial increases in listening effort, which in turn can have significant negative ramifications for listeners, such as increased stress and fatigue, as well as the availability of fewer remaining resources to direct towards concurrent cognitive-linguistic operations. Because auditory masking is ubiquitous in real-world social and community environments (e.g. restaurants, stores, family/social gatherings), gaining a better understanding of this topic is crucial in understanding everyday communication in PWA. This proposal therefore consists of a close investigation into listening effort in aphasia under auditory masking conditions. This investigation is part of a comprehensive training plan that will allow the candidate to gain proficiency in specific tools—including pupillometry, electroencephalography (EEG), and structural magnetic resonance imaging (MRI)—and apply them to address several research aims, under the advisement of a mentoring team of experienced scientists. During the mentored phase, the project will aim to examine whether listening effort is higher in PWA than in age- and hearing-matched controls, as well as to identify possible relationships between brain lesion location and listening effort in PWA. During this initial phase, the candidate will receive training in pupillometry and EEG as measures of listening effort, as well as in structural MRI to collect data on lesion location, in order to compare listening effort in PWA vs controls. During the independent phase, the project will aim to assess the effects of several specific types of auditory masker manipulations, including masker type and location, on listening effort in PWA and controls. Finally, the effect of increased listening effort on verbal working memory in PWA will be directly examined. Throughout the project, careful consideration will be given to differentiating between the effects of aphasia, age, and hearing loss on listening effort. Results will provide critical information about how auditory masking affects PWA, and may have implications for social engagement, community participation, and quality of life in this population. Completion of the project will also allow the candidate to launch an independent research career investigating clinically relevant questions in aphasia and related neurogenic cognitive-communication disorders.

项目概要/摘要 失语症是中风的常见后果，影响着美国大约 100 万人 越来越多的研究表明，慢性病患者往往会持续存在这种情况。 失语症（PWA）在理解背景语音方面比年龄和听力匹配的对照组差 声音或听觉掩蔽是存在的，但是目前人们对于如何进行听觉掩蔽知之甚少。 影响 PWA 中的听力努力，即用于解码的认知资源。 听觉信号——是接受语音处理研究中的一个关键结构。 掩蔽器通常会导致听力努力的大幅增加，这反过来又会产生显着的负面影响 对听众的影响，例如压力和疲劳增加，以及剩余的可用时间减少 因为听觉掩蔽无处不在。 在现实世界的社交和社区环境（例如餐馆、商店、家庭/社交聚会）中，获得 更好地理解这个主题对于理解 PWA 中的日常交流至关重要。 因此，该提案包括对听觉失语症患者的听力努力进行仔细调查。 这项调查是综合培训计划的一部分，该计划将使候选人能够 熟练掌握特定工具，包括瞳孔测量、脑电图 (EEG) 和结构分析 磁共振成像（MRI）——并根据建议将其应用于解决几个研究目标 一个由经验丰富的科学家组成的指导团队在指导阶段的目标是检查。 PWA 中的听力努力是否高于年龄和听力匹配的对照组，以及确定 在 PWA 的初始阶段，大脑病变位置和听力努力之间可能存在关系。 候选人将接受瞳孔测量和脑电图方面的培训，作为听力努力的衡量标准，以及结构方面的培训 MRI 收集病变位置的数据，以便比较 PWA 与对照期间的听力努力。 独立阶段，该项目旨在评估几种特定类型的听觉掩蔽器的效果 操作，包括掩蔽器类型和位置，对 PWA 和控件中的收听效果的影响。 在整个项目中，将直接检查 PWA 中言语工作记忆的听力努力。 将仔细考虑区分失语症、年龄和听力损失对 聆听努力的结果将提供有关听觉掩蔽如何影响 PWA 的重要信息，并且可能会产生影响。 对该人群的社会参与、社区参与和生活质量的影响。 该项目还将允许候选人开展临床调查的独立研究生涯 失语症和相关神经源性认知沟通障碍的相关问题。

项目成果

Energetic and informational masking place dissociable demands on listening effort: Evidence from simultaneous electroencephalography and pupillometrya).

精力充沛和信息掩蔽对聆听努力提出了分离的要求：来自同步脑电图和瞳孔测量的证据a)。

• 发表时间: 2023-08-01
• 作者: Villard, Sarah;Perrachione, Tyler K;Lim, Sung;Alam, Ayesha;Kidd, Gerald
• 通讯作者: Kidd, Gerald