Blood Diseases

血液疾病

• 批准号: 7644365
• 负责人: BERNARD G FORGET
• 金额: $ 45.77万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7644365
• 关键词: Hematological Disease

DESCRIPTION (provided by applicant): This proposal requests support for an ongoing research training program centered in the Hematology Section of the Department of Internal Medicine at Yale University School of Medicine. The Program provides trainees with the research experience needed to develop independent careers in areas relevant to blood diseases. Its primary objective will continue to be development of the investigative careers of M.D., Ph.D., and M.D./Ph.D. trainees. Two to three fellows per year will be recruited for intensive laboratory-based research training lasting 2-3 years. A typical M.D. or M.D./Ph.D. trainee will have already completed residency and one year of clinical training in hematology/oncology. Ph.D. postdoctoral trainees with research interests in molecular and cellular hematology/oncology are also recruited to the program. Trainees devote 80-90% effort to bench research supervised by a participating faculty member. Research experience is supplemented by participation in Sectional, Departmental, and campus-wide seminars, national meetings, and graduate level courses, including courses on research methods and the responsible conduct of research. Research progress and career development is monitored by a progress committee consisting of the research mentor, program director, and two participating faculty members. Research opportunities emphasize cellular and molecular biological analysis of tissues and molecules important for differentiation, function, and diseases of blood cells, including: erythrocyte membrane skeleton protein genes, and their genetic disorders; hematopoietic stem cell biology; genomics and proteomics; lymphoid and monocytic surface molecules; early events in hematopoietic cell differentiation; granulocyte maturation; oncogene expression; immunohematology; molecular virology; immunogenetics; gene transfer; molecular oncology; and endothelial cell biology. Research training takes place within the outstanding research environment of Yale University in well equipped and funded laboratories. The participating faculty includes academic hematologists and oncologists, and basic scientists in the fields of genetics, molecular biology, pathology, cell biology, immunobiology, and basic biology, many of whom are nationally and internationally renowned, and are united by common research interests and collaborations. The program offers trainees an opportunity to perform meaningful research and to develop investigative careers in hematology within a fertile intellectual environment populated by an outstanding interdisciplinary faculty.

描述（由申请人提供）： 该提案要求支持正在进行的研究培训计划，该计划以耶鲁大学医学院内科学系的血液学部门为中心。该计划为受训者提供了在与血液疾病有关的领域发展独立职业所需的研究经验。它的主要目标将继续是M.D.，Ph.D.和M.D./ph.d的调查职业的发展。学员。每年将招募两到三个研究员，以持续2 - 3年的持续实验室研究培训。典型的M.D.或M.D./ph.d。学员将已经完成了居住和血液学/肿瘤学临床培训的一年。博士该计划还招募了具有分子和细胞血液学/肿瘤学研究兴趣的博士后学员。 学员投入了80-90％的努力，以由参与教职员工监督的研究。研究经验补充了参加分区，部门和校园范围内的研讨会，全国会议以及研究生级课程，包括有关研究方法的课程和负责任的研究课程。研究进度和职业发展受到一个进度委员会的监测，该委员会由研究导师，计划主任和两名参与的教职员工组成。研究机会强调了对血液细胞分化，功能和疾病重要的组织和分子的细胞和分子生物学分析，包括：红细胞膜骨架蛋白基因及其遗传疾病；造血干细胞生物学；基因组学和蛋白质组学；淋巴样和单核表面分子；造血细胞分化的早期事件；粒细胞成熟；癌基因表达；免疫系统；分子病毒学；免疫遗传学；基因转移；分子肿瘤学；和内皮细胞生物学。研究培训发生在耶鲁大学在设备齐全和资助的实验室的杰出研究环境中进行。参与的教师包括学术血液学家和肿瘤学家，以及遗传学，分子生物学，病理学，细胞生物学，免疫生物学和基本生物学领域的基础科学家，其中许多人在国内和国际上享有著名，并由共同的研究利益和协作结合在一起。该计划为受训者提供了进行有意义的研究，并在由杰出的跨学科教师培养的肥沃的智力环境中发展血液学的调查职业。