CEPHALEXIN VS CLINDAMYCIN

头孢氨苄 VS 克林霉素

• 批准号: 7604701
• 负责人: AARON CHEN
• 金额: $ 0.11万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604701
• 关键词: Abscess; Adverse effects; Antibiotics; Cephalexin; Cephalosporins; Childhood; Clindamycin; Communities; Computer Retrieval of Information on Scientific Projects Database; Cutaneous; Depth; Disease Outbreaks; Funding; Grant; Incision and drainage; Individual; Infection; Infectious Skin Diseases; Institution; Manufactured football; Nosocomial Infections; Outpatients; Penicillins; Purpose; Reporting; Research; Research Personnel; Resistance; Resources; Retrospective Studies; Role; Skin; Soft Tissue Infections; Source; Treatment Failure; Treatment outcome; United States National Institutes of Health; cost; intravenous administration; methicillin resistant Staphylococcus aureus; pediatrician

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been associated with hospital-acquired infections. In the late 1990's, emergence of a new strain of MRSA within previously healthy individuals was noted in the community. This strain, termed CA-MRSA, often caused impressive deep-seated infections that usually required incision and drainage. Outbreaks within communities, and recently reported in a national football team, have become widespread. Very few studies hav evaluated the proper treatment of CA-MRSA infections. Traditionally, most skin and soft tissue infections were treated with cephalosporin or penicillin antibiotics (for which CA-MRSA would be expected to be resistant), yet many retrospective studies have reported that widespread treatment failures did NOT occur. Furthermore, changes in treatment practices to antibiotics for which CA-MRSA might be susceptible can be problematic in terms of increased cost, necessity of intravenous infusion, or side effect profile. The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by CA-MRSA. We hypothesize that treatment with cephalexin, a penicillin-like antibiotic to which CA-MRSA would be expected to be resistant, does not result in poorer outcomes than treatment with clindamycin, an antibiotic to which CA-MRSA is most often susceptible. This study will hopefully help pediatricians in the community and outpatient setting choose an appropriate antibiotic in the empiric treatment of a presumed CA-MRSA cutaneous abscess.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 传统上，耐甲氧西林金黄色葡萄球菌（MRSA）与医院获得的感染有关。 在1990年代后期，社区中发现了以前健康个体中新的MRSA菌株的出现。 这种称为CA-MRSA的菌株通常会引起令人印象深刻的深层感染，通常需要切口和排水。 社区内的爆发，最近在国家橄榄球队中报道了广泛报道。 很少有研究评估了CA-MRSA感染的适当治疗。 传统上，大多数皮肤和软组织感染都用头孢菌素或青霉素抗生素治疗（预计CA-MRSA将具有抗药性），但许多回顾性研究报告说，没有发生广泛的治疗失败。 此外，在成本增加，静脉输注的必要性或副作用概况方面，CA-MRSA可能会易感的抗生素的治疗方法的变化可能是有问题的。 这项研究的目的是帮助定义抗生素在CA-MRSA引起的小儿皮肤感染中的作用。 我们假设用头孢霉素治疗是一种青霉素样的抗生素，预计CA-MRSA将具有抗性，不会导致比用克林霉素治疗的较差的结局，而克林霉素是一种CA-MRSA最常见的抗生素。 这项研究有望帮助社区中的儿科医生和门诊环境选择适当的抗生素，以对假定的CA-MRSA皮肤脓肿进行经验治疗。