CHANGES IN COGNITIVE FUNCTION IN WOMEN ON REVIVAL

女性认知功能因复兴而发生的变化

• 批准号: 7604570
• 负责人: ADRIAN S. DOBS
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604570
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cross-Sectional Studies; Double-Blind Method; Estrogen Replacement Therapy; Funding; Grant; Ingestion; Institution; Investigation; Isoflavones; Memory; Neuropsychological Tests; Performance; Phytoestrogens; Placebo Control; Placebos; Plants; Postmenopause; Purpose; Randomized; Reporting; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Week; Woman; cognitive function; dietary supplements; improved; long term memory; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Longitudinal and cross-sectional studies of postmenopausal women indicate that performance on tasks of memory improves following estrogen replacement therapy (Sherwin, 2002 for a review; Duka T et al, 2000; Smith YR et al, 2001; Maki et al, 2001). Recently, the use of plant-derived products rich in isoflavone phytoestrogens, known to exert weak estrogenic action, have been shown to improve performance in young men and women on tests of short- and long-term memory (File et al., 2001). The purpose of the present study is to determine if the use of Revival, a popular dietary supplement containing naturally occurring isoflavones, leads to improved memory function in postmenopausal women. We propose to conduct a double-blind, placebo-controlled investigation of the effects of an isoflavone dietary supplement, Revival, taken for 12 weeks, on a neuropsychological test battery that includes assessment of memory function in 100 postmenopausal women (50 women randomized to receive Revival, 50 women randomized to receive placebo). We hypothesize that the ingestion of Revival will result in superior memory performance in postmenopausal women in a manner similar to that seen with estrogen replacement therapy, and consistent with reports in eugonadal subjects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 对绝经后妇女的纵向和横断面研究表明，雌激素替代疗法后记忆任务的表现得到改善（Sherwin，2002 年综述；Duka T 等人，2000 年；Smith YR 等人，2001 年；Maki 等人，2001 年）。 最近，使用富含异黄酮植物雌激素的植物衍生产品（已知具有微弱的雌激素作用）已被证明可以提高年轻男性和女性在短期和长期记忆测试中的表现（File et al., 2001） 。 本研究的目的是确定使用 Revival（一种含有天然异黄酮的流行膳食补充剂）是否可以改善绝经后妇女的记忆功能。 我们建议对服用 12 周的异黄酮膳食补充剂 Revival 对神经心理学测试组的影响进行双盲、安慰剂对照调查，其中包括对 100 名绝经后女性（50 名女性随机接受治疗）的记忆功能进行评估复兴，50 名女性随机接受安慰剂）。 我们假设，摄入 Revival 会导致绝经后女性的记忆表现优异，其方式与雌激素替代疗法相似，并且与性腺功能正常受试者的报告一致。