SLEEP AND PCOS

睡眠与多囊卵巢综合症

• 批准号: 7604763
• 负责人: DAVID A EHRMANN
• 金额: $ 7.66万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604763
• 关键词: Cardiovascular alteration; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Hormonal; Hyperinsulinism; Institution; Metabolic; Metabolic syndrome; Protocols documentation; Research; Research Personnel; Resources; Sleep; Sleep disturbances; Source; Testing; United States National Institutes of Health; Woman

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol has three Specific Aims: 1. to test the hypothesis that sleep disturbances are caused by the hormonal alterations (specifically hyperandrogenemia and hyperinsulinemia) that characterize women with PCOS; 2. to test the hypothesis that sleep disturbances cause the hormonal, metabolic and cardiovascular alterations seen in women with PCOS; 3. to test the hypothesis that in normal young women, experimental manipulations of sleep that partially recapitulate the sleep disturbances characteristic of women with PCOS will result in metabolic, hormonal, and cardiovascular alterations that are typical of the metabolic syndrome.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该方案具有三个特定的目的：1。检验以下假设：睡眠障碍是由荷尔蒙改变（特别是高狂异常血症和高胰岛素血症）引起的，该假设是PCOS女性的特征。 2。检验以下假设，即睡眠障碍会导致PCOS女性的激素，代谢和心血管改变； 3。为了检验以下假设：在正常的年轻女性中，对睡眠的实验性操纵部分概括了PCOS女性的睡眠障碍特征将导致代谢，荷尔蒙和心血管改变是代谢综合征的典型特征。