RENAL MINERAL DELIVERY

肾脏矿物质输送

• 批准号: 7604764
• 负责人: FREDERIC L COE
• 金额: $ 0.42万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604764
• 关键词: Age; Apatites; Basement membrane; Blood specimen; Calcitriol; Calcium; Calcium Oxalate; Calculi; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Creatinine clearance measurement; Crystal Formation; Crystallization; Deposition; Duct (organ) structure; Funding; Grant; Height; Hour; Institution; Insulin; Kidney; Kidney Calculi; Kidney Papilla; Limb structure; Measures; Minerals; Not Site Specific; Patients; Proteins; Purpose; Research; Research Personnel; Resources; Sampling; Serum; Site; Source; United States National Institutes of Health; Urine; Weight; Work; brushite; calcium phosphate; design; driving force; feeding; hypercalciuria; inhibitor/antagonist; rhenanite; sex; urinary; Age; Apatites; Basement membrane; Blood specimen; Calcitriol; Calcium; Calcium Oxalate; Calculi; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Creatinine clearance measurement; Crystal Formation; Crystallization; Deposition; Duct (organ) structure; Funding; Grant; Height; Hour; Institution; Insulin; Kidney; Kidney Calculi; Kidney Papilla; Limb structure; Measures; Minerals; Not Site Specific; Patients; Proteins; Purpose; Research; Research Personnel; Resources; Sampling; Serum; Site; Source; United States National Institutes of Health; Urine; Weight; Work; brushite; calcium phosphate; design; driving force; feeding; hypercalciuria; inhibitor/antagonist; rhenanite; sex; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent work has shown that calcium kidney stone formers have deposits of calcium phosphate (apatite) in their renal papillae, which serve as anchor points for stones. In patients calcium oxalate stones, mineral deposits are found in the interstitium, and the initial site of formation is the basement membrane of the thin limbs of Henle. In others, usually calcium phosphate stone formers, crystal deposits are located in the terminal collecting ducts. The mechanisms by which high urine calcium promotes mineral deposition at specific sites are not known. The objective of the project is to understand the driving forces for the formation of apatite plaque in the kidneys of patients with calcium kidney stones and the forces driving collecting duct.crystal formation in in brushite stone formers. For this purpose, we studied a group of hypercalciuric stone formers and comparable non-stone formers. All subjects were admitted to the GCRC for 14 hours, where they were fed 3 defined meals designed by the CRC dietician to vary with respect to protein and carbohydrate content, but to have equivalent amounts of calcium, phosphate and sodium. One hour urine samples were collected and blood samples were draw at the end of each urine and at the mid-points of the first 2 hours after each meal. Serum and urine mineral levels were determined, as well as PTH, calcitriol and insulin levels. We have also measured all urine factors needed to calculate urine supersaturation with respect to calcium oxalate and calcium phosphate, and as well the ability of each urine to inhibit crystal formation, an indicator of the level of urinary inhibitors of crystallization. Results were analyzed with appropriate adjustment for sex, age, creatinine clearance, height and weight.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 最近的工作表明，钙肾结石形成器在其肾乳头上有磷酸钙（磷灰石）的沉积物，它们是石材的锚点。在草酸钙钙的患者中，在间质中发现了矿物质沉积物，最初的地位位点是亨勒薄肢的地下膜。 在其他情况下，通常是磷酸钙结石，晶体沉积物位于末端收集管道中。 尚不清楚高尿钙在特定部位促进矿物质沉积的机制。该项目的目的是了解钙肾结石患者肾脏形成磷灰石斑块的驱动力，以及在刷子石材形成器中驱动导管的力。为此，我们研究了一组高钙石像和可比的非石材形成器。 所有受试者均被GCRC接纳14小时，在那里，他们被喂食3个由CRC营养师设计的定义的餐食，以在蛋白质和碳水化合物含量方面变化，但含量相当于钙，磷酸盐和钠。收集一小时的尿液样本，并在每次尿液的末端以及每顿饭后的前2小时的中点抽取血液样本。确定血清和尿液矿物质水平，以及PTH，钙三醇和胰岛素水平。 我们还测量了相对于草酸钙和磷酸钙计算尿液过饱和所需的所有尿素因子，以及每种尿液抑制晶体形成的能力，这是结晶尿液抑制剂水平的指标。 通过适当调整性别，年龄，肌酐清除率，身高和体重，分析结果。