CRF AND PERSONALITY

CRF 与个性

• 批准号: 7604759
• 负责人: Royce Lee
• 金额: $ 1.21万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604759
• 关键词: Adult; Affect; Animal Model; Behavioral; Brain; Childhood; Computer Retrieval of Information on Scientific Projects Database; Corticotropin-Releasing Hormone; Data; Early-life trauma; Funding; Grant; Hormones; Human; Hypothalamic structure; Institution; Measures; Monkeys; Personality; Personality Disorders; Psychopathology; Questionnaires; Rattus; Recording of previous events; Research; Research Personnel; Resources; Risk Factors; Source; Stress; United States National Institutes of Health; Up-Regulation; pediatric trauma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Childhood trauma is a risk factor for many psychopathologies, including personality disorder. Although the mechanism in humans by which childhood trauma affects the brain to cause personality disorder is unknown, animal models exist which implicate the hypothalamic-pitutary axis. Animal models in rats and monkeys find evidence that early life trauma causes an upregulation in the expression of brain corticotrophin-releasing factor along with increased behavioral stress reactivity. Pilot data that has already been collected is consistent with a direct realtionship between history of childhood trauma and adult CSF corticotropin-releasing factor levels. The specific aim of the proposed project is to investigate the realtionship between history of childhood trauma as measured by the Childhood Truama Questionnaire and stress hormone alterations in adult, personality disordered subjects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 简介：童年创伤是许多精神病理学（包括人格障碍）的危险因素。 尽管童年创伤影响大脑引起人格障碍的人类机制尚不清楚，但存在动物模型，这意味着下丘脑旁诊断轴。 大鼠和猴子中的动物模型发现，早期生命创伤在脑皮质营养蛋白释放因子的表达以及行为应激反应增加的情况下引起上调。 已经收集的试点数据与儿童创伤史与成人CSF皮质激素释放因子水平之间的直接房地产一致。 拟议项目的具体目的是调查儿童创伤史之间的房地产，如儿童期Truama问卷和成人人格障碍受试者的压力激素改变所衡量的。