ROLE OF MINERALOCOTICOID RECEPTOR IN OBESITY-RELATED ENDOTHELIAL DYSFUNCTION

盐皮质激素受体在肥胖相关内皮功能障碍中的作用

• 批准号: 7604511
• 负责人: Demetra Christou
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604511
• 关键词: Abdomen; Acute; Aldosterone; Blood Vessels; Blood flow; Cardiovascular Diseases; Cardiovascular system; Central obesity; Clinical; Computer Retrieval of Information on Scientific Projects Database; Coronary; Event; Fatty acid glycerol esters; Functional disorder; Funding; Future; Grant; Impairment; Individual; Institution; Intra-abdominal; Measures; Mediating; Mineralocorticoid Receptor; Mineralocorticoids; Nitric Oxide; Obesity; Oxidative Stress; Patients; Physiological; Play; Prevalence; Range; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Vascular Endothelium; Vasodilation; Visceral; Woman; abdominal fat; eplerenone; men; receptor; response; Abdomen; Acute; Aldosterone; Blood Vessels; Blood flow; Cardiovascular Diseases; Cardiovascular system; Central obesity; Clinical; Computer Retrieval of Information on Scientific Projects Database; Coronary; Event; Fatty acid glycerol esters; Functional disorder; Funding; Future; Grant; Impairment; Individual; Institution; Intra-abdominal; Measures; Mediating; Mineralocorticoid Receptor; Mineralocorticoids; Nitric Oxide; Obesity; Oxidative Stress; Patients; Physiological; Play; Prevalence; Range; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Vascular Endothelium; Vasodilation; Visceral; Woman; abdominal fat; eplerenone; men; receptor; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flow-mediated dilation (FMD) reflects the ability of the vascular endothelium to produce vasodilation in response to physiological increases in blood flow. It is primarily mediated by the release of vascular endothelium derived nitric oxide. Brachial FMD is reduced in many types of cardiovascular diseases (CVD). Brachial FMD correlates with coronary vascular endothelial function and predicts future cardiovascular events in patients with CVD. FMD is also impaired in individuals with high intra-abdominal fat, which may contribute to the increased prevalence of CVD in these individuals. Therefore, identifying the mechanisms involved in the impairment of brachial FMD with abdominal visceral obesity has important clinical implications. Experimental evidence suggests that mineralocorticoid receptor (MR)-induced oxidative stress plays a critical role in impaired FMD. Because abdominal visceral obesity is also associated with increased oxidative stress levels and the mineralocorticoid aldosterone, it is possible that at least part of the increased oxidative stress within the arterial wall seen with obesity may be due to an increased formation of ROS by the activation of MR, contributing to the obesity-related decline in FMD. Consequently, the specific aim of this study is to measure FMD before and after acute MR blockade with Eplerenone in men and women with a broad range of abdominal visceral fat.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 流动介导的扩张（FMD）反映了血管内皮产生血管舒张的能力，以响应血液流动的生理增加而产生血管舒张。 它主要是由衍生的一氧化氮的血管内皮释放介导的。 在许多类型的心血管疾病（CVD）中，臂FMD降低了。 臂FMD与冠状动脉血管内皮功能相关，并预测CVD患者的未来心血管事件。 FMD在高腹内脂肪的个体中也受到损害，这可能导致这些个体中CVD患病率的增加。 因此，确定肱臂FMD伴有腹部内脏肥胖的机制具有重要的临床意义。 实验证据表明，矿物皮质激素受体（MR）诱导的氧化应激在FMD受损中起关键作用。 由于腹部内脏肥胖症也与氧化应激水平升高和盐皮质激素醛固酮有关，因此至少有可能肥胖的动脉壁中氧化应激的一部分增加可能是由于MR的激活增加了ROS的增加，从而导致FMD肥胖相关的下降。 因此，这项研究的具体目的是在急性MR封锁前后用eplerenone在腹部内脏脂肪范围广泛的男性和女性中测量FMD。