High-Sensitivity Molecular Imaging with Ultrasound

高灵敏度超声波分子成像

基本信息

批准号：
7690425
负责人：
Paul A Dayton
金额：
$ 4.01万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-19 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7690425
关键词：
Acoustics Adhesions Algorithms Animal Cancer Model Animal Model Animals Area Attention Binding Biological Markers Biomedical Engineering Blood Blood Circulation Blood Vessels Caliber California Cancer Center Chemical Engineering Chemistry Chickens Clinical Clinical Medicine Collaborations Communities Contrast Media Deposition Detection Development Diagnosis Disease Drug Formulations Embryo Endothelium Erythrocytes Exhibits Fluorescence Microscopy Frequencies Human Resources Image Imaging technology Implant In Vitro Inflammation Integrin alphaVbeta3 Integrins Investigation Length Ligands Lipid Chemistry Lipids Malignant Neoplasms Medical Medical Imaging Methodology Methods Microbubbles Microbubbles Ultrasound Contrast Medium Microscopy Modality Modeling Molecular Profiling Molecular Target Movement Neoplasm Metastasis Noise Numbers Pathology Pathology, Other Photography Physiologic pulse Population Probability Property Pulse taking Qualifying Radiation Range Rattus Research Research Personnel Resolution Resources Rheology Scheme Signal Transduction Site Software Engineering Specificity Speed System Techniques Testing Thrombus Time Tissues Transducers Translating Translations Ultrasonics Ultrasonography Universities Ursidae Family Vascular Endothelium Veterinary Medicine Veterinary Schools angiogenesis arteriole base chorioallantoic membrane clinical Diagnosis clinically relevant computerized data processing concept cost density design desire experience hemodynamics improved in vivo intravital microscopy matrigel membrane model molecular imaging new technology novel portability pressure response size targeted delivery tool tumor tumor growth venule

项目摘要

DESCRIPTION (provided by applicant): Recently, the development of targeted contrast agents for molecular imaging has caught the attention of the medical and scientific community. Targeted ultrasound contrast agents, microbubbles which bear adhesion ligands to specific molecular targets expressed in areas such as angiogenesis, inflammation, or thrombus have the potential to make a significant impact in the detection, assessment, and localization of pathologies otherwise undetectable with medical imaging. Because of the convenience and availability of ultrasound as an imaging technology, targeted contrast agents for use with ultrasound have the potential to rapidly transform this modality into an even more powerful clinical tool. Unfortunately, recent studies with targeted ultrasound contrast agents have failed to illustrate the sensitivity hoped for to make this technique revolutionary. In this proposal, we present a plan to increase the sensitivity of ultrasound to targeted contrast agents over an order of magnitude. Our model target for these studies is angiogenesis (the formation of new blood vessels), which is required for tumor growth beyond 1-2 mm in diameter. The integrin alpha(v)beta(3) is over-expressed in regions of angiogenesis, and has been shown to correlate with tumor grade. These properties make the alpha (v)beta(3) integrin an ideal target for site-directed contrast agents. This proposal describes a three-part method to achieve the desired substantial increase in sensitivity by combining a completely new contrast agent with a novel contrast agent delivery technique, and we package these improvements with the substantially improved detection strategies only possible due to the improvements in the agent and the delivery. The combined tools and experience of the Departments of Biomedical and Chemical Engineering, the School of Veterinary Medicine, and the Cancer Center at the University of California, Davis, provide a unique and qualified research group for implementing this new system for molecular imaging with ultrasound.

描述（由申请人提供）：近年来，用于分子成像的靶向造影剂的开发引起了医学界和科学界的关注。靶向超声造影剂是一种微泡，其带有与血管生成、炎症或血栓等区域表达的特定分子靶标的粘附配体，有可能对医学成像无法检测到的病理的检测、评估和定位产生重大影响。由于超声作为一种成像技术的便利性和可用性，与超声一起使用的靶向造影剂有可能迅速将这种方式转变为更强大的临床工具。不幸的是，最近对靶向超声造影剂的研究未能证明这项技术具有革命性的敏感性。在这项提案中，我们提出了一项计划，将超声对目标造影剂的敏感性提高一个数量级。我们这些研究的模型目标是血管生成（新血管的形成），这是肿瘤生长直径超过 1-2 毫米所必需的。整合素 α(v)β(3) 在血管生成区域过度表达，并已被证明与肿瘤分级相关。这些特性使 α (v)beta(3) 整合素成为定点造影剂的理想靶标。该提案描述了一种由三部分组成的方法，通过将全新的造影剂与新颖的造影剂输送技术相结合，实现所需的灵敏度大幅提高，并且我们将这些改进与显着改进的检测策略结合起来，这只有通过改进代理和送货。加州大学戴维斯分校生物医学和化学工程系、兽医学院和癌症中心的综合工具和经验为实施这一新的超声分子成像系统提供了一个独特且合格的研究小组。