Multidisciplinary Program in Female and Male Reproduction

女性和男性生殖多学科项目

• 批准号: 7439018
• 负责人: Eugene D. Albrecht
• 金额: $ 125.75万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7439018
• 关键词: Multidisciplinary; Program; Female; Male; Reproduction; Multidisciplinary; Program; Female; Male; Reproduction

DESCRIPTION (provided by applicant): The objective of the Specialized Cooperative Centers Program in Reproduction Research (SCCPRR) at the University of Maryland School of Medicine is to conduct innovative basic and clinical research on female and male reproductive biology and to apply the knowledge gained from these studies to improve understanding of the etiology and treatment of reproductive dysfunction and infertility in women and men. The thematic focus of this proposal is the role that estrogen plays in regulating maturation of primate fetal ovaries and testes during intrauterine development and vascular remodeling of the uterine endometrium during the menstrual cycle. In Project I (Gerald J. Pepe), the regulatory role of estrogen in utero in programming fetal ovarian follicular and oocyte development and the impact this has on fertility in adulthood will be assessed in the baboon. In Project II (Eugene D. Albrecht), the regulatory role of estrogen in utero in programming baboon fetal testicular and excurrent ductule/epididymal development and the impact this has on fertility in adulthood will be assessed. A combined clinical-basic research study is proposed in Project III (Robert D. Koos), to determine the role of estrogen and progesterone, acting via expression of angiostimulatory and angioinhibitory factors, on endometrial angiogenesis and vascular remodeling in vivo in baboons and in vitro in cocultures of human endometrial and vascular endothelial and mural cells. We will collaborate with experts in human and nonhuman primate reproductive biology at the University of Maryland SCCPRR, Eastern Virginia Medical School, the University of Pittsburgh SCCPRR, and the Johns Hopkins University SCCPRR. Each of the research projects will draw heavily upon the immunocytochemistry Core (Gloria E. Hoffman) for the cellular localization/expression of regulatory factors and receptors. Integration of the scientific effort in this SCCPRR will be achieved through the thematic focus on estrogen's role in developmental maturation of the reproductive system, use of the baboon as a nonhuman primate model, and an established tradition of collaborative research. The discoveries obtained in the baboon primate model are expected to translate to the human to advance knowledge of human reproductive biology.

描述（由申请人提供）：马里兰大学医学学院的专业合作中心计划（SCCPRR）的目标是进行女性和男性生殖生物学的创新基础和临床研究，并运用这些研究所获得的知识，以提高对病因学和对女性和地下妇女和地下妇女和地下和男生生殖功能障碍的理解和治疗。该提案的主题重点是雌激素在调节月经周期期间子宫内发育和子宫内膜的血管重塑过程中调节灵长类胎儿卵巢和睾丸成熟的作用。在项目I（Gerald J. Pepe）中，雌激素在子宫中的调节作用在编程胎儿卵巢卵泡和卵母细胞的发育中，以及这种对成年生育能力的影响将在狒狒中评估。在项目II（Eugene D. Albrecht）中，将评估雌激素在子宫内的调节作用在编程狒狒胎儿睾丸和外表象的膜和肠道膜/附睾发育以及这种对成年后的生育能力的影响。 A combined clinical-basic research study is proposed in Project III (Robert D. Koos), to determine the role of estrogen and progesterone, acting via expression of angiostimulatory and angioinhibitory factors, on endometrial angiogenesis and vascular remodeling in vivo in baboons and in vitro in cocultures of human endometrial and vascular endothelial and mural cells.我们将与马里兰州SCCPRR大学，弗吉尼亚东部医学院，匹兹堡SCCPRR大学和约翰·霍普金斯大学SCCPRR的人类和非人类灵长类动物生殖生物学专家合作。每个研究项目都将大力利用免疫细胞化学核心（Gloria E. Hoffman）来进行调节因素和受体的细胞定位/表达。通过主题关注雌激素在生殖系统发展成熟，将狒狒用作非人类灵长类动物模型以及既定的协作研究传统，将科学努力的整合在这一SCCPRR中。预计在狒狒灵长类动物模型中获得的发现将转化为人类，以促进对人类生殖生物学的了解。