Combating Antimicrobial Resistance through Rapid Implementation of Available Guidelines and Evidence (CARRIAGE)

通过快速实施现有指南和证据来对抗抗菌素耐药性 (CARRIAGE)

• 批准号: 10200821
• 负责人: CHARLESNIKA T EVANS
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200821
• 关键词: Address; Adherence; Advisory Committees; Antibiotic Resistance; Antibiotics; Antimicrobial Resistance; Bacterial Antibiotic Resistance; Behavior; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clostridium difficile; Collaborations; Combating Antibiotic Resistant Bacteria; Communicable Diseases; Consolidated Framework for Implementation Research; Data; Data Collection; Data Set; Development; Education; Engineering; Evaluation; Event; Evidence based practice; Feedback; Focus Groups; Fostering; Future; Goals; Government Agencies; Guidelines; Handwashing; Health; Health Care Costs; Health Services; Health care facility; Healthcare Systems; Hospitals; Infection; Infection Control; Infection prevention; Inpatients; Integrated Health Care Systems; Interview; Investments; Lead; Learning; Life; Mentors; Methods; Mission; Modeling; Occupational Health; Patient Care; Policies; Practice Guidelines; Prevention; Process; Provider; Public Health; Quality of Care; Records; Research; Research Design; Resistance; Safety; Scientist; Series; Services; Strategic Planning; Surveys; System; Time; Translating; Veterans; Work; acute care; antimicrobial; carbapenem-resistant Enterobacteriaceae; clinical decision support; clinical practice; contextual factors; design; drug resistant pathogen; health care delivery; health care quality; health care service organization; health care settings; healthcare-associated infections; implementation design; implementation intervention; implementation science; implementation strategy; improved; innovation; interest; multi-drug resistant pathogen; novel; pathogen; patient oriented; patient safety; prevent; programs; prospective; repaired; routine care; theories; transmission process; uptake

Background: Annually, at least two million illnesses and 23,000 deaths are caused by antibiotic-resistant bacteria in the US alone, with an annual impact of $20-35 billion in excess health care costs. The emergence of antibiotic resistance means the treatment of infections is becoming increasingly difficult, expensive, and, in some cases, nonexistent. Judicious use of antibiotics is essential to slow the emergence of resistance and extend the useful life of effective antibiotics, but prevention of resistance also requires efforts to control pathogen transmission across healthcare settings and reduce healthcare-associated infections. VA is not immune to this rising threat to patient safety, but our national, integrated healthcare system for Veterans offers unique opportunities to significantly alter the course of events and improve the outlook for our future through novel implementation and quality improvement efforts. Objectives: The goal of this QUERI program is to address the growing concern of antimicrobial resistance through strategies targeting improved use of antibiotics and prevention of healthcare-associated infections (HAI) across VA patient care settings. In doing so, we will address the priority goals of our VA operational partners, the QUERI Strategic Plans, the 2014 VHA Blueprint for Excellence, and the goals of the National Action Plan for Combating Antibiotic-resistant Bacteria as put forth by President Obama. Our specific objectives are to (a) promote judicious inpatient antibiotic use through a novel antibiotic self-stewardship "timeout" project that prompts VA providers to evaluate the continued need for antibiotics; (b) support and enhance the implementation of new VA guidelines to detect and prevent the spread of carbapenem-resistant Enterobacteriaceae in VA hospitals; (c) foster improved handwashing practice by repairing the broken audit- and-feedback mechanism in VA acute-care hospitals via a VISN-wide quality improvement project; and (d) evaluate and enhance the implementation of the national C. difficile bundle at VA acute-care facilities; Methods: Program projects will vary in study timeframe and start date over the five-year QUERI program timeframe. Research designs utilized across projects will include the experimental stepped wedge design for implementation of interventions, prospective observational designs of practice implementation of large-scale policy initiatives, and rigorous evaluation of VA national policies. The program will employ complementary implementation strategies and theories guided by an Implementation Core consisting of a team of notable VA implementation scientists with proven track records in designing and executing programs to control antimicrobial resistance and HAIs. Specific implementation strategies will include audit and feedback, clinical decision support, external facilitation, provider education and activation, and adherence engineering. The Promoting Action on Research in Health Services (PARiHS) framework will be used to assess contextual factors influencing implementation within facilities, while work system barriers and facilitators will be assessed using the Consolidated Framework for Implementation Research (CFIR) and the Systems Engineering Initiative for Patient Safety (SEIPS) model. Data collection methods will include the use of national VA datasets, direct observation, and primary data (i.e., surveys, interviews, and focus groups).

背景：每年，至少有 200 万人患病和 23,000 人死亡是由抗生素耐药性引起的 仅在美国，细菌每年就会造成 20-350 亿美元的超额医疗费用。的出现 抗生素耐药性意味着感染的治疗变得越来越困难、昂贵，并且 有些情况，不存在。明智地使用抗生素对于减缓耐药性的出现至关重要 延长有效抗生素的使用寿命，但预防耐药性还需要努力控制 病原体在医疗机构中传播并减少医疗相关感染。弗吉尼亚州不是 免受这种对患者安全日益严重的威胁的影响，但我们为退伍军人提供的国家综合医疗保健系统可以提供 显着改变事件进程并改善我们未来前景的独特机会 新颖的实施和质量改进工作。 目标：该 QUERI 计划的目标是解决日益增长的抗菌素耐药性问题 通过旨在改善抗生素使用和预防医疗相关感染的战略 (HAI) 覆盖 VA 患者护理机构。在此过程中，我们将实现 VA 运营的优先目标 合作伙伴、QUERI 战略计划、2014 年 VHA 卓越蓝图以及国家目标 奥巴马总统提出的抗击抗生素耐药细菌行动计划。我们的具体 目标是 (a) 通过新型抗生素自我管理促进住院患者明智地使用抗生素 “超时”项目促使 VA 提供者评估对抗生素的持续需求； (b) 支持和 加强新​​的 VA 指南的实施，以检测和防止碳青霉烯类抗生素耐药性的传播 退伍军人管理局医院的肠杆菌科细菌； (c) 通过修复破损的审核来促进改进的洗手习惯 通过 VISN 范围内的质量改进项目，在 VA 急症护理医院建立反馈机制；和（四） 评估和加强退伍军人管理局急性护理机构国家艰难梭菌捆绑包的实施； 方法：在五年 QUERI 项目中，项目项目的研究时间和开始日期会有所不同 大体时间。跨项目使用的研究设计将包括实验性阶梯楔形设计 干预措施的实施，大规模实践实施的前瞻性观察设计 政策举措，以及对 VA 国家政策的严格评估。该计划将采用互补的 由著名 VA 团队组成的实施核心指导的实施策略和理论 实施科学家在设计和执行控制程序方面拥有良好的记录 抗菌素耐药性和 HAI。具体实施策略将包括审核和反馈、临床 决策支持、外部促进、提供者教育和激活以及依从工程。这 促进卫生服务研究行动 (PARiHS) 框架将用于评估背景 影响设施内实施的因素，同时将评估工作系统的障碍和促进因素 使用实施研究综合框架（CFIR）和系统工程 患者安全倡议 (SEIPS) 模型。数据收集方法将包括使用国家 VA 数据集， 直接观察和原始数据（即调查、访谈和焦点小组）。

项目成果

Setting a Research Agenda in Prevention of Healthcare-Associated Infections (HAIs) and Multidrug-Resistant Organisms (MDROs) Outside of Acute Care Settings.

制定预防急性护理环境之外的医疗相关感染 (HAI) 和多重耐药生物 (MDRO) 的研究议程。

• 发表时间: 2018
• 影响因子: 4.5
• 作者: Evans, Charlesnika T;Jump, Robin L;Krein, Sarah L;Bradley, Suzanne F;Crnich, Christopher J;Gupta, Kalpana;Perencevich, Eli N;Vander Weg, Mark W;Morgan, Daniel J
• 通讯作者: Morgan, Daniel J

Epidemiology and outcomes associated with carbapenem-resistant Acinetobacter baumannii and carbapenem-resistant Pseudomonas aeruginosa: a retrospective cohort study.

与耐碳青霉烯类鲍曼不动杆菌和耐碳青霉烯类铜绿假单胞菌相关的流行病学和结果：一项回顾性队列研究。

• 发表时间: 2022-05-24
• 影响因子: 3.7
• 作者: Vivo, Amanda;Fitzpatrick, Margaret A;Suda, Katie J;Jones, Makoto M;Perencevich, Eli N;Rubin, Michael A;Ramanathan, Swetha;Wilson, Geneva M;Evans, Martin E;Evans, Charlesnika T
• 通讯作者: Evans, Charlesnika T

Laboratory practices for identification and reporting of carbapenem-resistant Enterobacteriaceae in Department of Veterans Affairs facilities.

退伍军人事务部设施中耐碳青霉烯类肠杆菌科细菌鉴定和报告的实验室实践。

• 发表时间: 2019-04
• 影响因子: 4.5
• 作者: Fitzpatrick, Margaret A;Suda, Katie J;Ramanathan, Swetha;Guihan, Marylou;Brown, Charnetta;Safdar, Nasia;Evans, Martin;Jones, Makoto M;Pfeiffer, Christopher D;Klutts, J Stacey;Icardi, Michael;Perencevich, Eli;Rubin, Michael;Evans, Charlesnika
• 通讯作者: Evans, Charlesnika

Increased carbapenemase testing following implementation of national VA guidelines for carbapenem-resistant Enterobacterales (CRE).

在实施国家 VA 耐碳青霉烯肠杆菌 (CRE) 指南后，增加了碳青霉烯酶检测。

• 发表时间: 2022
• 作者: Fitzpatrick, Margaret A;Suda, Katie J;Ramanathan, Swetha;Wilson, Geneva;Poggensee, Linda;Evans, Martin;Jones, Makoto M;Pfeiffer, Christopher D;Klutts, J Stacey;Perencevich, Eli;Rubin, Michael;Evans, Charlesnika T
• 通讯作者: Evans, Charlesnika T

Research Agenda for Microbiome Based Research for Multidrug-resistant Organism Prevention in the Veterans Health Administration System.

退伍军人健康管理系统中基于微生物组的多重耐药生物预防研究的研究议程。

• 发表时间: 2018
• 影响因子: 4.5
• 作者: Kates, Ashley E;Tischendorf, Jessica S;Schweizer, Marin;Herwaldt, Loreen;Samore, Matthew;Dukes, Kimberly C;Gerding, Dale N;Diekema, Daniel J;Safdar, Nasia
• 通讯作者: Safdar, Nasia