MODULATION AND NEUROPLASTIC BEHAVIOR IN INHERITENCE FORM OF HYPERTENSION

遗传性高血压的调节和神经塑性行为

• 批准号: 7631444
• 负责人: AZEEZ A AILERU
• 金额: $ 21.5万
• 依托单位: WINSTON-SALEM STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7631444
• 关键词: Action Potentials; Affect; African American; Animal Model; Animals; Antihypertensive Agents; Autonomic ganglion; Behavior; Biochemical; Biological; Blood Pressure; Cells; Cerebrovascular Circulation; Cervical; Chest; Data; Disease; Electric Stimulation; Event; Exhibits; Genetic; Genetic Models; Genetic Predisposition to Disease; Goals; High Blood Pressure; Human; Hypertension; Ion Channel; Knock-out; Knowledge; Lead; Maintenance; Modeling; Molecular; Monitor; Morbidity - disease rate; Nerve; Neuraxis; Neurons; Neurostimulation procedures of spinal cord tissue; Organism; Patch-Clamp Techniques; Pattern; Perception; Peripheral; Physiological; Physiology; Population; Preventive; Property; Purpose; Range; Rattus; Research; Signal Pathway; Signal Transduction; Sympathetic Ganglia; Sympathetic Nervous System; Synaptic Transmission; Synaptic plasticity; System; Techniques; Testing; Therapeutic; Therapeutic Intervention; Transgenic Organisms; United States; Work; base; caucasian American; expectation; health disparity; innovation; mortality; novel; postsynaptic; presynaptic; prevent; receptor; response; transmission process

Hypertension affects over 50 million people in the United States and is disturbingly higher in African Americans than in white Americans. Evidence suggests that a genetic predisposition to hypertension may underlie this health disparity. Studies suggest that hypertensive humans and animal models of hypertension exhibit increased peripheral sympathetic nervous system activity (SNA) but the knowledge of the events that lead to elevated SNA and its significance in the genesis and maintenance of elevated blood pressure is rudimentary.

高血压在美国影响超过5000万人，非洲人令人不安 美国人比白人美国人。有证据表明，高血压的遗传易感性 这是这种健康差异的基础。研究表明，高血压人和高血压的动物模型 表现出增加的外周交感神经系统活动（SNA），但对事件的了解 导致SNA升高及其在血压升高的起源和维持中的重要性是 基本。