COBRE CORE D: INFORMATICS SUPPORT CORE

COBRE CORE D：信息学支持核心

• 批准号: 7720752
• 负责人: RANDOLPH J. NOELLE
• 金额: $ 11.75万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720752
• 关键词: Bioinformatics; Budgets; Centers of Research Excellence; Communities; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Funding; Gel; Gene Expression; Genes; Genome; Genomics; Grant; Human; Informatics; Institution; Language; Microarray Shared Resource; Mus; Polymerase Chain Reaction; Proteomics; Research; Research Personnel; Resources; Scientist; Services; Slide; Source; Technology; Thinking; United States National Institutes of Health; cost; macromolecule; member; new technology; programs; protein purification

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Informatics Core is an administrative Core that provides support to COBRE members for the use of existing proteomics (Proteomics Facility Core) and genomics (Microarray Shared Resource) facilities at Dartmouth. We propose that by incentivizing the use of these Cores, it will provide valuable new technologies to the young COBRE investigators who may not have access to the technology due to limited budgets, as well as introduce to established investigators, new technologies with which they are not familiar. Extended, shared use of these Cores will create a sense of community and common language for scientists to interact between ongoing COBRE programs and the scientific community, as a whole. Within the Proteomics Core investigators will find support for the: 1. Isolation and purification of proteins, 2. 2D Gel Analysis of Macromolecules. 3. Mass Spectral Analysis of Macromolecules. 4. Quantitative Analysis of Biomolecular Interactions, 5. Bioinformatics Support Services. Within the MicroArray Shared Resource, COBRE members will find support for the: 1. Analysis of Gene Expression by QT-RT PCR, 2. Full-Genome transcriptional profiling of both of mouse and human genes and 3. Bioinformatics support. Resources provided to this Core will underwrite the cost of service, on a sliding scale, for present COBRE members, past COBRE members and members of other COBRE initiatives within the Dartmouth community. In addition to providing additional access to these Cores to COBRE members, we think that this initiative will strengthen and extend existing inter-COBRE interactions.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 信息学核心是一种管理核心，可为达特茅斯（Dartmouth）使用现有蛋白质组学（蛋白质组学设施核心）（蛋白质组学设施核心）（蛋白质组学设施核心）（MicroArray共享资源）提供支持。 我们建议，通过激励使用这些核心的使用，它将为年轻的Cobre调查人员提供有价值的新技术，他们可能由于预算有限而无法使用该技术，并向既定的研究人员介绍了他们不熟悉的新技术。 扩展，共同使用这些核心将为科学家创造一种社区感和通用语言，以使正在进行的鞋底计划与整个科学界之间的互动。在蛋白质组学中，核心研究人员将为1。蛋白质的分离和纯化，2。2D凝胶分析大分子的支持。 3。大分子的质谱分析。 4。生物分子相互作用的定量分析，5。生物信息学支持服务。 在微阵列共享资源中，cobre成员将为：1。通过QT-RT PCR对基因表达的分析，2。小鼠和人类基因的全基因组转录分析以及3。生物信息信息支持。提供给该核心的资源将以滑动规模的价格为目前的毛cre成员，过去的毛病成员以及达特茅斯社区中其他毛线倡议的成员承保服务成本。 除了向Cobre成员提供对这些核心的更多访问权外，我们认为该计划将加强和扩展现有的近代互动。