MAG. SOUR. IMAG. & THE RE-ORG. OF COGNIT. FUNCT. IN CHILDREN WITH SPINA BIFIDA

磁力。

• 批准号: 7409734
• 负责人: ANDREW C. PAPANICOLAOU
• 金额: $ 23.1万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7409734
• 关键词: Address; Attention; Birth; Brain; Cerebellar malformation; Cerebrum; Child; Classification; Cognitive; Comprehension; Discrimination; Face; First Pregnancy Trimester; Hydrocephalus; Image; Language; Magnetism; Maps; Mediating; Motor; Neurologic; Neurons; Parietal Lobe; Perception; Personal Satisfaction; Procedures; Reading; Role; Sampling; Source; Spinal Dysraphism; Stenosis; Upper Extremity; Variant; Visual Perception; Visual attention; base; research study; skills; somatosensory

The objective of this proposal is to utilize magnetic source imaging (MSI) to evaluate the organization of brain functions in children with spina bifida (SB). Children with SB sustain a congenital insult to the brain that begins in the first trimester and results in hydrocephalus that is usually treated at birth. It is well-established that many children with SB have unusual profiles of cognitive ability, with strengths in word reading, math facts, and object-based visual perception in the face of difficulties with reading comprehension, math procedures, and many aspects of action-based visual perception, attention, and motor function. What is unclear is how the SB brain mediates these functions and the extent to which variations within the SB group reflect differences in cerebral reorganization. In this proposal, we propose systematic explorations of functional organization of key motor, somatosensory, language, and cognitive skills that characterize the modal profile associated with SB in a sample of 136 children with SB, 20 with aqueductal stenosis (AS), and 60 controls. Four specific aims are proposed, each representing a separate experiment. Aim 1 (Motor, somatosensory, and language mapping) attempts to identify the brain activation profiles indicative of the neuronal mechanisms that mediate basic somatosensory and motor functions of the upper extremities as well as receptive language function among 136 SB children and 60 controls. Aim 2 (Reading and arithmetic) addresses the representation of reading and math skills in 60 children with SB who vary in these skills. Aim 3 (Visual attention) addresses the role of the parietal lobe in mediating visual attention skills using a line bisection task in 40 children with SB divided according to whether they show or do not show a leftward bias on a horizontal line bisection task in Project 3, and 20 controls. Aim 4 (Rhythm discrimination) uses a rhythm perception task to assess cerebellar function in 20 children with SB characterized by early hydrocephalus and a congenital cerebellar malformation, 20 with AS characterized by early hydrocephalus, but no cerebellar malformation, and 20 controls. The results should help establish how the congenitally malformed brain reorganizes function as well as help establish the basis for the neurological mechanisms by which these functions are mediated in children with SB.

该建议的目的是利用磁源成像（MSI）评估脊柱裂（SB）儿童的脑功能组织。患有SB的儿童维持对大脑的先天性侮辱，该侮辱始于头三个月，并导致通常在出生时接受治疗的脑积水。众所周知的是，许多SB的儿童具有不寻常的认知能力，具有文字阅读，数学事实和基于对象的视觉的优势 面对阅读理解，数学程序以及基于动作的视觉感知，注意力和运动功能的许多方面的许多方面的感知。尚不清楚的是SB脑如何介导这些功能以及SB组内的变化在多大程度上反映了脑重组的差异。在此提案中，我们提出了关键运动，体感，语言和认知能力的功能组织的系统探索，这些功能组织在136名SB儿童，20个具有含水狭窄的儿童（AS）和60个对照中的样本中与SB相关的模态概况的特征。提出了四个具体目标，每个目标都代表一个单独的实验。 AIM 1（运动，体感和语言映射）试图识别指示介导上肢基本体感和运动功能的神经元机制的大脑激活曲线以及接受 136名SB儿童和60个对照中的语言功能。 AIM 2（阅读和算术）解决了60名患有SB儿童的阅读和数学技能的表示，这些技能在这些技能方面有所不同。 AIM 3（视觉注意）（视觉注意）解决了顶叶在40个患有SB的儿童中使用线二分一分配任务在项目中分配的角色一分配任务中的作用 3和20个控件。 AIM 4（节奏歧视）使用节奏感知任务来评估20名患有早期脑积水和先天性小脑畸形为特征的SB儿童的小脑功能，其中20个为特征，其特征是早期脑积水，但没有小脑畸形和20个控制。结果应有助于确定先天性畸形的大脑如何重新组织功能，并有助于建立神经系统的基础 这些功能在SB儿童中介导的机制。