COBRE in Lipidomics and Pathobiology

COBRE 在脂质组学和病理生物学中的应用

• 批准号: 7276977
• 负责人: Lina M OBEID
• 金额: $ 219万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-26 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276977
• 关键词: COBRE; Lipidomics; Pathobiology

DESCRIPTION (provided by applicant): The emerging Center in Lipidomics and Pathobiology at the Medical University of South Carolina (MUSC) builds on substantial accomplishments during the first phase of the COBRE (Sept 2002 - July 2006). These include mentoring and retention of 10 targeted junior faculty investigators, 239 publications in peer review journals from by all COBRE participants (including 63 papers and 61 oral and poster presentations by target investigators), participation by more than 25 MUSC research faculty in COBRE activities, and development and enhancement of highly successful, innovative scientific core facilities, including a unique core in Lipidomics. The COBRE has also been very successful in recruiting minorities (3) and women (6) as target faculty. The strategic focus of the next phase is to establish a recognized research center that will compete effectively for ongoing peer-reviewed funding. The mentoring focus targets five additional highly promising junior investigators recently recruited to the field of lipidomics. The scientific focus remains on developing the field of lipidomics and applying it to the study of important pathobiological processes. The study of bioactive lipids and their functional involvement in clinically-relevant disorders has emerged as an area of exceptional strength at MUSC. The organizing hypothesis of this COBRE states that the diversity of bioactive lipids provides a rich network of pathways that regulate cell function. Dysfunctions in these pathways contribute to the pathobiology of specific diseases, including cancer progression and metastasis, accelerated aging, inflammation, and fungal pathogenesis. Counterbalancing the biological significance of lipids are unique considerations that arise from the relative difficulties of studying lipids and lipid-interacting proteins. These necessitate the development of competent shared facilities and collaborative efforts to bring various disciplines and expertise to bear on specific problems. Therefore, the overarching goal of this proposal is to develop an interdisciplinary Center of Lipidomics and Pathobiology that will facilitate and sustain this field of research. These goals will be advanced by pursuing the following specific aims: 1) Expand the critical mass of funded investigators in research areas encompassed by the COBRE, with a continued emphasis on mentoring; 2) Develop and enhance key areas of research infrastructure through the continued development of novel cores; and 3) Sustain the long-term viability of the COBRE through development of a Center for Lipidomics and Pathobiology at MUSC. These activities should result in a highly developed interdisciplinary research center with a critical mass of collaborative, independently and programmatically funded investigators in an evolving area of research of major significance to cancer biology, aging, inflammation, and infectious diseases.

描述（由申请人提供）：南卡罗来纳州医科大学（MUSC）的脂质组学和病理学新兴中心（MUSC）在柯布尔第一阶段（2002年9月至2006年7月）建立了重大成就。其中包括对10位有针对性的初级教师研究者的指导和保留，所有Cobre参与者的同行评审期刊的239个出版物（包括63篇论文和61篇针对目标研究者的口头和海报演讲），超过25位MUSC研究教师参与Cobre活动，以及非常成功的，包括非常成功，广泛的科学核心核心机构，包括一项独特的独特核心。该鞋底在招募少数族裔（3）和妇女（6）作为目标教师方面也非常成功。下一阶段的战略重点是建立一个公认的研究中心，该研究中心将有效地竞争进行同行评审的资金。这项指导重点针对五名高度有前途的初级调查人员，最近招募到脂质组学领域。科学的重点仍然放在发展脂肪态学领域，并将其应用于重要病理生物学过程的研究。生物活性脂质及其在与临床相关的疾病中的功能受累的研究已成为MUSC的特殊强度领域。该毛病的组织假设指出，生物活性脂质的多样性提供了调节细胞功能的丰富途径网络。这些途径的功能障碍有助于特定疾病的病理生物学，包括癌症进展和转移，加速衰老，炎症和真菌发病机理。平衡脂质的生物学意义是源于研究脂质和脂质相互作用蛋白的相对困难引起的独特考虑。这些需要开发有能力的共享设施和协作努力，以带来各种学科和专业知识，以解决特定问题。因此，该提案的总体目标是建立一个脂肪组学和病理生物学的跨学科中心，该中心将有助于和维持这一研究领域。这些目标将由 追求以下具体目的：1）扩大资金研究人员的关键质量 毛茸茸所包含的区域，继续着重于指导； 2）通过持续发展新核心，开发和增强了研究基础设施的关键领域； 3）通过在MUSC建立脂质症和病理学中心来维持毛病的长期生存能力。这些活动应导致一个高度发展的跨学科研究中心，并在对癌症生物学，衰老，炎症和感染性疾病的主要意义的不断发展的研究领域中进行了重要的协作，独立和程序化资助的研究者。