OMEGA-3 FATTY ACIDS, ASPIRIN, AND PLATELET FUNCTION

OMEGA-3 脂肪酸、阿司匹林和血小板功能

• 批准号: 7610340
• 负责人: WILLIAM S HARRIS
• 金额: $ 0.37万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610340
• 关键词: Address; Aspirin; Bleeding time procedure; Blood; Blood Clot; Blood Platelets; Blood coagulation; Coagulation Process; Computer Retrieval of Information on Scientific Projects Database; Eskimo Population; Fish Oils; Funding; Grant; Hemorrhage; Injury; Institution; Lead; Molecular; Myocardial Infarction; Omega-3 Fatty Acids; Pharmaceutical Preparations; Recruitment Activity; Research; Research Personnel; Resources; Risk; Site; Source; Tablets; Testing; United States National Institutes of Health; Week; base; day; Address; Aspirin; Bleeding time procedure; Blood; Blood Clot; Blood Platelets; Blood coagulation; Coagulation Process; Computer Retrieval of Information on Scientific Projects Database; Eskimo Population; Fish Oils; Funding; Grant; Hemorrhage; Injury; Institution; Lead; Molecular; Myocardial Infarction; Omega-3 Fatty Acids; Pharmaceutical Preparations; Recruitment Activity; Research; Research Personnel; Resources; Risk; Site; Source; Tablets; Testing; United States National Institutes of Health; Week; base; day

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Omega-3 fatty acids from fish oils are known to reduce the risk for heart attacks, but the precise mechanisms by which they do this are not clear. One of the earliest know effects of fish oils (first seen in Eskimos) was prolonged bleeding times. Bleeding times are mostly influenced by how well the blood platelets aggregate at a site of injury. Drugs like aspirin inhibit platelet function, making the blood less likely to clot, and (to a point) this is a good thing -- it reduces the risk for blood-clot based heart attack. (Of course, too much platelet inhibition can lead to hemorrhage, not a good thing). We know how aspirin inhibits platelet function, but how do omega-3 fatty acids do it? What are the molecular mechanisms by which they operate, and what happens if you give fish oils and aspirin TOGETHER? This project will address these questions. We will recruit 10 healthy subjects and then do a panel of platelet tests in four settings: at baseline, one day after taking an aspirin tablet, after 4 weeks of taking fish oils, and after taking one aspirin tablet while on fish oil.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 众所周知，来自鱼油的omega-3脂肪酸降低了心脏病发作的风险，但是这样做的确切机制尚不清楚。 鱼油的最早效果之一（首次在爱斯基摩人出现）是长时间的出血时间。 出血时间主要受损伤部位的血小板聚集的影响。 像阿司匹林这样的药物抑制血小板功能，使血液凝结的可能性降低，并且（至关重要的是）这是一件好事 - 它降低了基于血液闭合的心脏病发作的风险。 （当然，太多的血小板抑制会导致出血，而不是一件好事）。 我们知道阿司匹林如何抑制血小板功能，但是omega-3脂肪酸如何做到？ 它们运行的​​分子机制是什么？如果您一起给鱼油和阿司匹林，会发生什么？ 该项目将解决这些问题。 我们将招募10名健康受试者，然后在四个环境中进行一组血小板测试：在服用阿司匹林片剂后一天，服用鱼油4周后一天，以及在鱼油上服用一台阿司匹林片剂后。