Measurement of Neuroexcitation during Bladder Filling: A Novel Metric for Overactive Bladder Phenotyping

膀胱充盈过程中神经兴奋的测量：膀胱过度活动表型的新指标

基本信息

批准号：
10191877
负责人：
Adam Philip Klausner
金额：
$ 22.76万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-25 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10191877
关键词：
Acute Affect Age Anterior Area Base of the Brain Bladder Brain Brain region Chronic Consumption Data Development Diagnostic Engineering Esthesia Evaluation Event Functional Magnetic Resonance Imaging Functional disorder Future Gender Geography Goals Gold Hemoglobin Hydration status Image Individual Interdisciplinary Study Light Measurement Measures Methods Monitor Near-Infrared Spectroscopy Overactive Bladder Participant Pathway interactions Pattern Phase Phenotype Population Prefrontal Cortex Process Protocols documentation Research Research Design Sensory Stimulus Supine Position Symptoms Techniques Technology Testing Time Urodynamics Urology Validation Woman afferent nerve age group base brain pathway cingulate gyrus detector diagnostic technologies imaging modality improved men meter micturition urgency midbrain central gray substance multidisciplinary neuroimaging novel response urologic

项目摘要

Project Summary: Overactive Bladder (OAB), defined mainly by the symptom of urinary urgency, is a multifactorial condition, affecting more than 25% of the population. Because urgency is the brain's interpretation of multifactorial events, it is important to understand areas of brain activation that occur during bladder filling. Recently, there has been a growing body of research using functional MRI (fMRI) to identify brain regions and pathways associated with OAB. However, fMRI is expensive, time-consuming, and requires highly-specialized experts. Thus, a critical research objective is the development of office-based neuroimaging technologies to improve OAB phenotyping. Our multi-disciplinary research group combining urology, engineering, and neuroimaging expertise has made advances in the development of novel office-based technologies for OAB evaluation. We created a real-time Sensation Meter used during bladder filling. We also developed a novel functional Brain NIRS (fNIRS) protocol that shows localized regions of cortical neuroexcitation in response to bladder filling. Our hypothesis is that fNIRS can be used to identify different patterns of OAB representing new phenotypic subtypes. We will test our hypothesis in two aims. In the first aim, we will identify patterns of neuroexcitation with fNIRS during natural bladder filling in normal men and women with OAB using our established 3-fill hydration protocol. We will then use this information to evaluate age-matched women with OAB. The second aim will compare patterns of neuroexcitation with fNIRS and fMRI during natural bladder filling in women with OAB. Successful completion of this proposal will create new office-based neuroimaging technology using fNIRS that, in combination with our established sensation meter and hydration protocols, can ultimately be used for improved phenotyping of OAB in future studies. The data from this study will be used in subsequent multi-PI R01 proposals to test our fNIRS technology on larger participant groups with varying forms of voiding dysfunction and also to study the acute and chronic effects of OAB treatments on sensation and neuroimaging pathways.

项目概要：膀胱过度活动症 (OAB) 主要表现为尿急症状，是一种多因素病症，影响超过25%的人口。因为紧迫性是大脑对多因素事件的解释，了解膀胱充盈期间发生的大脑激活区域非常重要。近来，有越来越多的研究使用功能性 MRI (fMRI) 来识别与以下疾病相关的大脑区域和通路 OAB。然而，功能磁共振成像昂贵、耗时，并且需要高度专业化的专家。因此，一个关键的研究目标是开发基于办公室的神经影像技术以改善 OAB 表型。我们的多学科研究小组结合了泌尿学、工程学和神经影像学专业知识，取得了用于 OAB 评估的新型办公技术的开发进展。我们创建了一个实时膀胱充盈期间使用的感觉计。我们还开发了一种新颖的功能性脑近红外光谱 (fNIRS) 协议显示了响应膀胱充盈的皮质神经兴奋的局部区域。我们的假设是 fNIRS 可用于识别代表新表型亚型的 OAB 的不同模式。我们将在两个目标上检验我们的假设。第一个目标是，我们将使用 fNIRS 识别神经兴奋模式使用我们既定的 3 次填充水合方案，对患有 OAB 的正常男性和女性进行自然膀胱充盈。然后，我们将使用这些信息来评估年龄匹配的 OAB 女性。第二个目标将比较患有 OAB 的女性膀胱自然充盈过程中 fNIRS 和 fMRI 的神经兴奋模式。该提案的成功完成将使用 fNIRS 创建新的基于办公室的神经影像技术，与我们既定的感觉计和水合方案相结合，最终可用于改善未来研究中 OAB 的表型分析。本研究的数据将用于后续的多 PI R01 提案中在具有不同形式排尿功能障碍的较大参与者群体中测试我们的 fNIRS 技术研究 OAB 治疗对感觉和神经影像通路的急性和慢性影响。