PHYSIOLOGY OF HEART RATE RECOVERY AFTER SUBMAXIMAL EXERCISE IN SUBJECTS WITH CAD

CAD 受试者次极量运动后心率恢复的生理学

• 批准号: 7604258
• 负责人: JEFFREY J GOLDBERGER
• 金额: $ 6.03万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604258
• 关键词: PHYSIOLOGY; HEART; RATE; RECOVERY; AFTER

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The risk of sudden death is increased during and following exercise. Diminished resting parasympathetic tone is also associated with increased mortality. Recently, attenuated heart rate recovery after exercise has been shown to predict mortality yet, no information is available regarding the interaction between exercise and parasympathetic tone on cardiac electrophysiology. The aim of the proposed study is to test the following hypotheses: a) there is diminished effect of parasympathetic reactivation on recovery of heart rate and QT interval in subjects with coronary artery disease and left ventricular dysfunction. This will be assessed by sequential exercise testing with and without parasympathetic blockade in subjects with coronary artery disease with and without moderate to severe left ventricular dysfunction; b) new non-invasive indices of heart rate variability during recovery are correlated with the effects of parasympathetic reactivation on recovery of heart rate and QT interval. This study will provide important insight into the pathophysiologic link between diminished parasympathetic tone and the risk of sudden death. The results may support the use of specific indices of parasympathetic tone during exercise and/or recovery as prognostic markers rather than indices derived at rest.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 运动期间和运动后猝死的风险会增加。 静息副交感神经张力减弱也与死亡率增加有关。 最近，运动后心率恢复减弱已被证明可以预测死亡率，但尚无关于运动与副交感神经张力之间对心脏电生理学的相互作用的信息。 本研究的目的是检验以下假设：a) 副交感神经重新激活对冠状动脉疾病和左心室功能障碍受试者心率和 QT 间期恢复的影响减弱。 这将通过对患有或不患有中度至重度左心室功能障碍的冠状动脉疾病受试者进行有或没有副交感神经阻滞的序贯运动测试来评估； b) 恢复期间新的非侵入性心率变异性指标与副交感神经重新激活对心率和 QT 间期恢复的影响相关。 这项研究将为了解副交感神经张力减弱与猝死风险之间的病理生理联系提供重要的见解。 结果可能支持在运动和/或恢复期间使用特定的副交感神经张力指数作为预后标记，而不是在休息时得出的指数。