PHYSIOLOGY OF HEART RATE RECOVERY AFTER SUBMAXIMAL EXERCISE IN SUBJECTS WITH CAD

CAD 受试者次极量运动后心率恢复的生理学

• 批准号: 7604258
• 负责人: JEFFREY J GOLDBERGER
• 金额: $ 6.03万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604258
• 关键词: PHYSIOLOGY; HEART; RATE; RECOVERY; AFTER

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The risk of sudden death is increased during and following exercise. Diminished resting parasympathetic tone is also associated with increased mortality. Recently, attenuated heart rate recovery after exercise has been shown to predict mortality yet, no information is available regarding the interaction between exercise and parasympathetic tone on cardiac electrophysiology. The aim of the proposed study is to test the following hypotheses: a) there is diminished effect of parasympathetic reactivation on recovery of heart rate and QT interval in subjects with coronary artery disease and left ventricular dysfunction. This will be assessed by sequential exercise testing with and without parasympathetic blockade in subjects with coronary artery disease with and without moderate to severe left ventricular dysfunction; b) new non-invasive indices of heart rate variability during recovery are correlated with the effects of parasympathetic reactivation on recovery of heart rate and QT interval. This study will provide important insight into the pathophysiologic link between diminished parasympathetic tone and the risk of sudden death. The results may support the use of specific indices of parasympathetic tone during exercise and/or recovery as prognostic markers rather than indices derived at rest.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 运动期间和之后的猝死风险增加。 静息副交感神经的降低也与死亡率增加有关。 最近，运动后的心率恢复已被证明可以预测死亡率，尚无有关运动和副交感神经生理学上的相互作用的信息。 拟议的研究的目的是检验以下假设：a）副交感神经重新激活对冠状动脉疾病和左心室功能障碍受试者心率和QT间隔的恢复的影响减少。 这将通过在有或没有中度至重度左心室功能障碍的受试者中进行有或没有副交感的受试者进行连续的运动测试来评估这一点； b）恢复过程中心率变异性的新的非侵入性指标与副交感神经重新激活对心率和QT间隔的恢复的影响相关。 这项研究将提供对副交感神经降低与猝死风险之间的病理生理联系的重要见解。 结果可能支持在运动和/或恢复过程中用作预后标记的特定指标，而不是在静止下得出的指数。