Applications of Polymerization-induced Phase Separation of Restorative Materials

聚合诱导的修复材料相分离的应用

• 批准号: 7643315
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 37.08万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7643315
• 关键词: Acids; Address; Biocompatible Materials; Bisphenol A-Glycidyl Methacrylate; Chemistry; Clinical; Complex; Coupling; Dental; Development; Diffuse; Dimensions; Drug Formulations; Exposure to; Filler; Free Radicals; Healthcare; Heterogeneity; Individual; Interphase; Kinetics; Lead; Life; Mechanics; Methacrylates; Morphology; Patients; Performance; Phase; Plant Resins; Polymers; Process; Property; Reaction; Recovery; Relative (related person); Relaxation; Research; Route; Services; Staging; Stress; Structure; Surface; Swelling; System; Time; Tissues; Variant; Water; Work; base; composite restoration; crosslink; design; dimer; functional group; improved; interfacial; irradiation; monomer; nano; next generation; novel; photopolymerization; polymerization; polymerization shrinkage; programs; restoration placement; restorative material; uptake

DESCRIPTION (provided by applicant): In 1999, patients in the USA received 85,788,400 composite restorations and the numbers continue to rise. Dental composite restorations represent the most prevalent exposure to biomaterials designed to restore form and function of replaced tissues. As such, further improvements in these widely used materials will have a considerable health care impact. While current materials are generally good, dental composites still suffer from deficiencies that limit their utility and performance. These problems include: relatively low conversion leading to leachable monomer, which along with water uptake, provide a decline in mechanical properties over time; lack of toughness; and most significantly, excessive polymerization shrinkage that causes stress. Shrinkage and stress associated with polymerization mean that intact restored margins can not be achieved reliably. All these problems complicate the placement of restorations and limit their service life. In this project, we address these issues through the inherent versatility of polymeric materials that allows controlled formation of heterogeneous structures. Polymerization-induced phase separation will be used to create nano- to micro-scale heterogeneous polymeric materials with high conversion, improved toughness and notably, with minimal stress development due to a late-stage shrinkage recovery unique to this approach. The research plan provides for development of (i) all-methacrylate resin compositions that form heterogeneous polymers, (ii) controlled formation of heterogeneous interpenetrating polymer networks obtained by simultaneous free radical and cationic photopolymerization processes applied to mixtures of monomers with different reactive functional groups and (iii) introduction of novel surface treatments for reinforcing fillers that provide a complementary additional tailored interface in composite materials based on the phase-separating resins. The proposed program will clearly delineate the effective control parameters that can be used to manipulate the polymerization-induced phase separation process to produce low shrinkage and low stress polymeric materials with improved strength, durability and toughness relative to conventional homogeneous materials. These resulting composite formulations will be suitable as next generation, improved dental restoratives. This research will advance fundamental understanding of complex polymeric systems while providing short- and medium-term clinical benefits with restorative materials.

描述（由申请人提供）：1999年，美国的患者接受了85,788,400份综合修复体，数量继续增加。牙科复合修复体是最普遍的暴露于旨在恢复替代组织的形式和功能的生物材料的暴露。因此，这些广泛使用的材料的进一步改进将产生可观的医疗保健影响。尽管当前的材料通常是好的，但牙科复合材料仍然遭受限制其效用和性能的缺陷。这些问题包括：相对较低的转化率导致可渗出的单体随着水的吸收，随着时间的推移提供了机械性能的下降；缺乏韧性；最重要的是，过度的聚合收缩会导致压力。与聚合相关的收缩和压力意味着无法可靠地实现完整的恢复边缘。所有这些问题使修复体的放置变得复杂并限制了他们的使用寿命。在这个项目中，我们通过聚合物材料的固有多功能性来解决这些问题，该材料允许控制异质结构的控制形成。聚合诱导的相分离将用于创建具有高转化率，较高韧性的纳米至微尺度异质聚合物材料，并且由于这种方法独有的后期收缩恢复而导致应力的发展最小。该研究计划为开发（i）形成异构聚合物的全甲基丙烯酸酯树脂组成，（ii）通过同时适用于与不同反应式功能型混合物的同时自由基和阳离子光聚聚合过程获得的异质互穿的聚合物网络的受控形成。 （iii）引入新型的表面处理，以增强填充剂，以基于相分离树脂提供互补的复合材料量身定制界面。拟议的程序将清楚地描述有效的控制参数，可用于操纵聚合诱导的相分离过程，以产生低收缩和低应力聚合物材料，相对于常规均匀材料，强度，耐用性和韧性提高了。这些由此产生的复合制剂将适合作为下一代，改善牙齿修复剂。这项研究将促进对复杂聚合系统的基本了解，同时通过恢复性材料提供短期和中期临床益处。