Facility Core B--Pulmonary Toxicology

设施核心B——肺毒理学

• 批准号: 7599000
• 负责人: Peter S Thorne
• 金额: $ 27.37万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7599000
• 关键词: Acute; Aerosols; Airway Resistance; Allergens; Animal Model; Animals; Area; Asthma; Behavior; Biological Assay; Biological Markers; Biology; Breathing; Consultations; Core Facility; Development; Devices; Disease; Dose; End Point; Endotoxins; Environmental Health; Evaluation; Exposure to; Funding; Gases; Generations; Goals; Host resistance; Inhalation Exposure; Inhalation Therapy; Inhalation Toxicology; Knockout Mice; Lung; Lung diseases; Maintenance; Measurement; Methodology; Nose; Performance; Physiological; Predisposition; Prevention; Productivity; Property; Research; Research Personnel; Rodent; Sampling; Science; Scientist; Services; Structure of parenchyma of lung; System; Systems Analysis; Testing; Toxicology; Transgenic Organisms; improved; innovation; interest; methacholine; nanoparticulate; novel; post-doctoral training; pre-doctoral; resistance factors; response; toxicant; vapor

The goal of the Pulmonary Toxicology Facility Core (PTF, formerly the Inhalation Toxicology Facility) is to provide the facilities and expertise for EHSRC investigators to enhance the productivity and quality of their pulmonary toxicology research and to assist them in exploring new investigative areas in asthma, pulmonary biology, inhalation toxicology, or aerosol science. In addition, investigators from NIEHS-funded Environmental Health Centers are supported with expertise and assays for evaluation of exposures to asthma triggers. This facility provides assistance for testing hypotheses regarding the: ¿ Pulmonary biology of asthma and other environmental lung diseases; ¿ Development and prevention of environmental lung disease; ¿ Physicochemical properties and behavior of endotoxin, allergens, bioaerosols, and other airborne toxicants; and ¿ Performance of sampling devices commonly used by aerosol scientists and hygienists for environmental assessment.

肺毒理学设施核心（PTF，以前是吸入毒理学设施）的目标是 为EHSRC调查人员提供设施和专业知识，以提高其生产率和质量 肺毒理学研究并协助他们探索哮喘的新调查区域， 肺生物学，吸入毒理学或气溶胶科学。此外，来自NIEHS资助的调查员 环境卫生中心得到了专业知识和测定的支持，以评估 哮喘触发。该设施为测试有关以下情况的假设提供了帮助。 „哮喘和其他环境肺部疾病的肺生物学； �环境肺部疾病的发展和预防； �内毒素，过敏原，生物溶质和其他空气寄生的物理化学特性和行为 有毒物质；和 �气雾科学家和卫生学家通常使用的采样设备的性能 环境评估。