RODENT MODELS CORE

啮齿动物模型核心

• 批准号: 7712875
• 负责人: MARSHA RUTH MAILICK
• 金额: $ 28.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7712875
• 关键词: Achievement; Animals; Behavioral; Caring; Central Nervous System Diseases; Consultations; Cryopreservation; Data; Data Analyses; Developmental Disabilities; Engineering; Equipment; Future; Generations; Guidelines; Knock-out; Laboratories; Laboratory Animals; Location; Maintenance; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Mouse Strains; Mus; Neurodegenerative Disorders; Phenotype; Publications; Quality of Care; Rattus; Research; Research Personnel; Research Project Grants; Resources; Rodent; Rodent Model; Services; Training; Transgenic Organisms; Universities; behavior test; cost; design; feeding; member; model development; mutant; novel; research study

INTRODUCTION The Rodent Models Core provides technical support for the generation and characterization of transgenic and knockout strains of mice, access to expensive behavioral equipment for mice and rats that can be shared among several investigators, and expertise in the behavioral phenotyping of mouse and rat models of MRDD and related disorders of the CNS. In addition, the Core is responsible for the care, feeding, and recordkeeping related to the use of mice and rats by MRDDRC projects and the maintenance of specific rodent models of development, developmental disabilities, and neurodegenerative diseases. This Core has been renamed during the present project period, reflecting a sharpening of its focus and considerable new expertise and services added during the past five years in order to be both responsive to the growing and changing needs of MRDDRC investigators and to contribute to the evolving scientific agenda of the MRDDRC. The space allocated to this Core is in the midst of a major renovation that, as of January 2005, resulted in the temporary relocation of all animals to other facilities on campus, with reassignment of the caretaker staff to those facilities. While renovation is taking place, Core services are continuing uninterrupted at those alternate locations. This description of the Rodent Models Core includes an explanation of how this Core will operate when the animals return in 2007, with newly trained staff who will operate this exceptional and fully modernized facility serving the diverse scientific needs of MRDDRC investigators using rodent models. In the description below, the present tense is used to portray resources and services that continue uninterrupted in temporary locations during the renovation, past tense is used to refer to improvements made prior to the renovation, and future tense is used to refer to new Core services that will be provided after the renovation is completed in 2007. Therefore, the description of the Rodent Models Core reflects the strengths of past accomplishments as well as the promise of future achievements.

介绍 啮齿动物模型核心为转基因的产生和表征提供技术支持和 小鼠的敲除菌株，可以分享的小鼠和老鼠的昂贵行为设备 在几个研究者中 和中枢神经系统的相关疾病。此外，核心负责护理，喂养和记录保存 与MRDDRC项目使用小鼠和大鼠的使用以及特定啮齿动物的维护有关 发育，发育障碍和神经退行性疾病的模型。这个核心一直是 在本项目期间重命名，反映了其重点和相当大的新专业知识的提升 和过去五年中添加的服务，以既响应不断增长又会变化 MRDDRC研究人员的需求，并为MRDDRC的不断发展的科学议程做出贡献。 分配给该核心的空间是在2005年1月的重大翻新中 将所有动物临时搬迁到校园的其他设施，重新分配看护人的工作人员 这些设施。在进行翻新时，核心服务在这些替代方面继续不间断 位置。对啮齿动物模型核心的描述包括对该核心将如何运行的解释 当动物在2007年返回时，新训练的员工将经营这种杰出而完全现代化的 使用啮齿动物模型，为MRDDRC研究人员提供多种科学需求的设施。在描述中 下面，当前时态用于描绘临时不间断的资源和服务 翻新期间的位置，过去时态用于指修改之前进行的改进，以及 未来时态用于参考翻新完成后将提供的新核心服务 2007年。因此，对啮齿动物模型核心的描述反映了过去成就的优势 以及未来成就的希望。