Vitamin D status in pregnant women

孕妇的维生素 D 状况

• 批准号: 7617944
• 负责人: Theresa O. Scholl
• 金额: $ 19.5万
• 依托单位: UNIV OF MED/DENT NJ-SCH OSTEOPATHIC MED
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7617944
• 关键词: African American; Biological Assay; Birth Weight; Cardiovascular Diseases; Characteristics; Cholecalciferol; Complication; Conceptions; Data; Early Diagnosis; Elderly; Ergocalciferols; Ethnic Origin; Fasting; Fetal Growth Retardation; Food; Gestational Diabetes; High Pressure Liquid Chromatography; Hispanics; Human; Infant; Life; Low Birth Weight Infant; Low income; Methods; Minority; New Jersey; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevention; Public Health; Puerto Rican; Research; Research Personnel; Risk; Risk Factors; Sampling; Screening procedure; Seasons; Skin; Skin Pigmentation; Supplementation; Ultraviolet B Radiation; United States; Vitamin D; Vitamin D Deficiency; Vitamin D2; Vulnerable Populations; Weight Gain; Woman; cohort; dietary supplements; fortification; high risk; pregnant; prognostic; public health relevance; reproductive

DESCRIPTION (provided by investigator): Vitamin D is present in food either naturally or by fortification and included in nutritional supplements. It is also synthesized photochemically by the skin from ultraviolet B radiation. Vitamin D synthesis varies by season and with latitude as well as according to intensity of skin pigmentation. Recent research in the United States found lower circulating levels of 25 (OH) D, the primary indicator of vitamin D status, among minority women who were either pregnant or in their reproductive years. The extent to which maternal vitamin D has an influence on the course and outcome of human pregnancy remains to be more completely studied. We propose to use the HPLC method to assay cholecaliferol (vitamin D3) and ergocalciferol (vitamin D2) to assess maternal vitamin D status. This will be accomplished by analyzing existing fasting samples and data derived from the 2001-2006 cohort (N=1510) of young, low income minority gravidae from Camden, New Jersey to determine: 1. The prognostic importance of maternal vitamin D status for birth weight, gestation duration and poor pregnancy outcomes (low birth weight, preterm delivery, fetal growth restriction). 2. The relation of maternal vitamin D status to important complications of pregnancy (gestational diabetes and pre-eclampsia). 3. The relationship of maternal vitamin D status to maternal diet and supplement use, season of year, ethnicity, overweight/obesity, and other maternal characteristics. PUBLIC HEALTH RELEVANCE: This project has important public health implications for early detection and prevention of adverse pregnancy outcomes in a vulnerable population. If pregnant women who are vitamin D deficient are at risk, then screening and supplementation before conception or early in gestation before a complication develops or an adverse outcome occurs is feasible. The research also has implications for ethnic disparities during pregnancy. African American and some Hispanic groups (e.g. Puerto Ricans) are at increased risk of bearing low birth weight infants who are delivered preterm or small for gestation, of developing gestational diabetes and, some studies suggest, pre-eclampsia (1,2). If vitamin D deficiency is a risk factor for any or all of these problems then the underlying cause will have been uncovered and the disparity will be preventable. Underscoring the importance of prevention during reproductive life is the fact that small infants born to the women may be at high risk of cardiovascular disease and type 2 diabetes in later life.

描述（研究人员提供）：维生素D自然或通过防御能力存在于食物中，并包括在营养补充剂中。它也是由紫外线B辐射的皮肤在光化学上合成的。维生素D合成随季节和纬度以及皮肤色素沉着强度而变化。美国最近的研究发现，在怀孕或生殖年中，较低的循环水平为25（OH）D，这是维生素D状况的主要指标。孕产妇维生素D对人类怀孕的过程和结果有影响的程度尚待更全面地研究。我们建议使用HPLC方法分析胆固醇（维生素D3）和Ergocalciferol（维生素D2）来评估母体维生素D状态。这将通过分析来自新泽西州卡姆登市的年轻，低收入的少数少数族裔少数族裔少数族裔少数民族（n = 1510）来得出的现有禁食样本和数据来实现：1。产妇维生素D状况对出生体重，妊娠持续时间和不良怀孕的预后重要性（低出生体重，胎儿生长，胎儿的差异，胎儿，胎儿生长，胎儿）。 2。母体维生素D状态与妊娠重要并发症的关系（妊娠糖尿病和前子糖尿病）。 3。孕产妇维生素D状况与孕产妇饮食和补充使用，一年的季节，种族，超重/肥胖和其他母体特征的关系。公共卫生相关性：该项目对脆弱人群的早期发现和预防不良怀孕结局具有重要的公共卫生影响。如果缺乏维生素D的孕妇处于危险之中，那么在并发症发生之前或发生妊娠期的早期筛查和补充是可行的。该研究还对怀孕期间的种族差异有影响。非洲裔美国人和一些西班牙裔群体（例如波多黎各人）的风险增加，患有早产或小的婴儿体重为妊娠，患妊娠糖尿病，并且一些研究表明，先前的诊断前（1,2）。如果维生素D缺乏症是任何或全部这些问题的危险因素，那么基本原因将被发现，并且差异将是可以预防的。强调在生殖生活期间预防的重要性是，妇女出生的小婴儿可能患有心血管疾病的高风险和后来的2型糖尿病。