REGIONAL HETEROGENEITY OF OVINE MYOFIBER INCLINATION ANGLE

绵羊肌纤维倾斜角的区域异质性

• 批准号: 7601916
• 负责人: Daniel B Ennis
• 金额: $ 0.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601916
• 关键词: Anterolateral; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Depth; Funding; Grant; Heart; Helix (Snails); Heterogeneity; Histological Techniques; Institution; Lateral; Left ventricular structure; Location; Modeling; Performance; Publishing; Research; Research Personnel; Resources; Slice; Source; United States National Institutes of Health; Variant; ear helix; insight; papillary muscle; regional difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Quantification of myofiber inclination angle is necessary for calculating myofiber shortening strains and for modeling cardiac performance. This study offers insight into the regional differences in transmural myofiber inclination angle. Quantitative histologic techniques were used to characterize regional variations in myofiber orientation by examining the local helix angle in five healthy ovine hearts at an average of 9.4 (SD 2.2) transmural locations in eight circumferentially arranged blocks and within four slices across the left ventricle (LV). The mean midwall myofiber inclination angle was -7¿ (SD 9), but was better characterized by spatial heterogeneity (an average of 0¿ in the posterolateral and anterolateral wall near the papillary muscles, and -9¿ in all other regions). The transmural pitch (angular change per wall depth) averaged 93¿ (SD 21) and was lowest in the posterior wall (51¿ in the basal posterior sector) and highest in the anterolateral wall (130¿ in the mid-equatorial anterolateral sector). Transmural myofiber orientations were fit with cubic functions with a mean RMS error of 18¿ (SD 6¿). The lowest RMS fit error was in the lateral mid-equatorial sector (9¿) and highest RMS fit error was in the basal postero-septal sector (33¿) indicating that myofiber arrangement in the postero-septal wall may be less conserved than within the lateral wall. Our results corroborate previously published results, but importantly highlight regional differences in myofiber organization that may impact any results obtained from computational models.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 肌纤维倾斜角的量化对于计算肌纤维缩短应变和模拟心脏性能是必要的。本研究通过检查局部螺旋角来深入了解透壁肌纤维倾斜角的区域差异。在五个健康的绵羊心脏中，在八个圆周排列的块和左心室的四个切片内平均有 9.4 (SD 2.2) 个透壁位置(LV) 平均中壁肌纤维倾斜角为-7¿ （SD 9），但更好地以空间异质性为特征（乳头肌附近的后外侧和前外侧壁平均为 0¿，所有其他区域的平均跨壁节距（每个壁深度的角度变化））。 93° （SD 21），后壁最低（后基底区 51¿），前侧壁最高（中赤道前外侧区 130¿），透壁肌纤维方向与具有平均 RMS 的三次函数拟合。误差18° (SD 6¿). 最低的 RMS 拟合误差在外侧中赤道部分 (9¿)，最高的 RMS 拟合误差在基底后间隔部分 (33¿)，表明后间隔壁中的肌纤维排列。我们的结果证实了先前发表的结果，但重要的是强调了肌纤维组织的区域差异，这可能会影响从计算模型获得的任何结果。