REGIONAL HETEROGENEITY OF OVINE MYOFIBER INCLINATION ANGLE

绵羊肌纤维倾斜角的区域异质性

• 批准号: 7601916
• 负责人: Daniel B Ennis
• 金额: $ 0.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601916
• 关键词: Anterolateral; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Depth; Funding; Grant; Heart; Helix (Snails); Heterogeneity; Histological Techniques; Institution; Lateral; Left ventricular structure; Location; Modeling; Performance; Publishing; Research; Research Personnel; Resources; Slice; Source; United States National Institutes of Health; Variant; ear helix; insight; papillary muscle; regional difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Quantification of myofiber inclination angle is necessary for calculating myofiber shortening strains and for modeling cardiac performance. This study offers insight into the regional differences in transmural myofiber inclination angle. Quantitative histologic techniques were used to characterize regional variations in myofiber orientation by examining the local helix angle in five healthy ovine hearts at an average of 9.4 (SD 2.2) transmural locations in eight circumferentially arranged blocks and within four slices across the left ventricle (LV). The mean midwall myofiber inclination angle was -7¿ (SD 9), but was better characterized by spatial heterogeneity (an average of 0¿ in the posterolateral and anterolateral wall near the papillary muscles, and -9¿ in all other regions). The transmural pitch (angular change per wall depth) averaged 93¿ (SD 21) and was lowest in the posterior wall (51¿ in the basal posterior sector) and highest in the anterolateral wall (130¿ in the mid-equatorial anterolateral sector). Transmural myofiber orientations were fit with cubic functions with a mean RMS error of 18¿ (SD 6¿). The lowest RMS fit error was in the lateral mid-equatorial sector (9¿) and highest RMS fit error was in the basal postero-septal sector (33¿) indicating that myofiber arrangement in the postero-septal wall may be less conserved than within the lateral wall. Our results corroborate previously published results, but importantly highlight regional differences in myofiber organization that may impact any results obtained from computational models.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 肌纤维倾斜角的定量对于计算肌纤维缩短应变和对心脏性能进行建模是必需的。这项研究提供了对透壁肌纤维倾斜角区域差异的见解。定量的组织学技术用于通过检查五个健康卵巢心脏中的局部螺旋角度，平均在八个圆周布置的块中，在四个切片中以五个健康的位置检查局部螺旋方向的区域变化。平均中间的肌纤维倾斜角为-7（SD 9），但以空间异质性为特征（在乳头肌肉附近的后载膜和前外侧壁中为0？，在所有其他地区为-9。）。透壁俯仰（每个壁深度变化）平均为93（SD 21），在后壁中最低（基本后扇区中的51？），在前侧壁中最高（在中外侧的内侧外侧部门为130€）。透壁肌纤维方向与三次函数拟合，平均RMS误差为18？（SD 6。）。最低的RMS拟合误差是在侧端部门（9€）中，最高的RMS拟合误差在基本的后隔板扇区（33？），表明后隔壁壁中的肌纤维排列可能比横向壁内的构成构成。我们的结果证实了先前发表的结果，但重要的是强调了肌纤维组织中的区域差异，这些差异可能会影响从计算模型获得的任何结果。