COMPARISON OF HEMODYNAMIC AND NEURAL RESPONSES IN CAT VISUAL CORTEX USING COMPL

使用 COMPL 比较 CAT 视觉皮层的血流动力学和神经反应

• 批准号: 7601624
• 负责人: C KAYSER
• 金额: $ 6.49万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601624
• 关键词: Animals; Complex; Computer Retrieval of Information on Scientific Projects Database; Count; Dependence; Dissociation; Felis catus; Frequencies; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Institution; Measures; Range; Relative (related person); Research; Research Personnel; Resources; Signal Transduction; Site; Source; Spike Potential; Stimulus; United States National Institutes of Health; Visual Cortex; analog; blood oxygenation level dependent response; hemodynamics; relating to nervous system; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We compare fMRI-BOLD responses in anesthetized cats with local field potentials (LFPs), aggregate high-frequency responses (analog-Mua) and spiking activity recorded in primary and higher visual cortex of alert animals. The similarity of the activations in these electrophysiological signals to those in the BOLD is quantified by counting recording sites where different stimuli elicit the same relative activation as in the imaging experiments. Using artificial stimuli, a comparison of BOLD and LFP strongly depends on the frequency range used. Stimulating with complex or natural stimuli reduces this frequency dependence and yields a good match of LFP and BOLD. In general, this match is best between 20 and 50 Hz. The measures of high-frequency activity behave qualitatively different: the responses of the analog-Mua match those of the LFP; the spiking activity shows a low concordance with the BOLD signal. This dissociation of BOLD and spiking activity is most prominent upon stimulation with natural stimuli.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们将麻醉猫的 fMRI-BOLD 反应与局部场电位 (LFP)、聚合高频反应（模拟 Mua）以及警觉动物的初级和高级视觉皮层中记录的尖峰活动进行比较。这些电生理信号中的激活与粗体中的激活的相似性是通过对不同刺激引起与成像实验中相同的相对激活的记录位点进行计数来量化的。使用人工刺激，BOLD 和 LFP 的比较很大程度上取决于所使用的频率范围。用复杂或自然的刺激来刺激可以减少这种频率依赖性，并产生 LFP 和 BOLD 的良好匹配。一般来说，这种匹配在 20 到 50 Hz 之间效果最好。高频活动的测量在性质上有所不同：模拟 Mua 的响应与 LFP 的响应相匹配；尖峰活动与 BOLD 信号的一致性较低。这种 BOLD 和尖峰活动的分离在自然刺激的刺激下最为突出。