COMPARISON OF HEMODYNAMIC AND NEURAL RESPONSES IN CAT VISUAL CORTEX USING COMPL

使用 COMPL 比较 CAT 视觉皮层的血流动力学和神经反应

• 批准号: 7601624
• 负责人: C KAYSER
• 金额: $ 6.49万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601624
• 关键词: Animals; Complex; Computer Retrieval of Information on Scientific Projects Database; Count; Dependence; Dissociation; Felis catus; Frequencies; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Institution; Measures; Range; Relative (related person); Research; Research Personnel; Resources; Signal Transduction; Site; Source; Spike Potential; Stimulus; United States National Institutes of Health; Visual Cortex; analog; blood oxygenation level dependent response; hemodynamics; relating to nervous system; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We compare fMRI-BOLD responses in anesthetized cats with local field potentials (LFPs), aggregate high-frequency responses (analog-Mua) and spiking activity recorded in primary and higher visual cortex of alert animals. The similarity of the activations in these electrophysiological signals to those in the BOLD is quantified by counting recording sites where different stimuli elicit the same relative activation as in the imaging experiments. Using artificial stimuli, a comparison of BOLD and LFP strongly depends on the frequency range used. Stimulating with complex or natural stimuli reduces this frequency dependence and yields a good match of LFP and BOLD. In general, this match is best between 20 and 50 Hz. The measures of high-frequency activity behave qualitatively different: the responses of the analog-Mua match those of the LFP; the spiking activity shows a low concordance with the BOLD signal. This dissociation of BOLD and spiking activity is most prominent upon stimulation with natural stimuli.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们比较了与局部场电位（LFP），骨料高频反应（模拟-MUA）以及在警报动物的初级和更高视觉皮层中记录的局部场电位（LFP），高频反应（模拟MUA）和尖峰活性的fMRI-bold反应。通过计算记录位点，在这些电生理信号中激活与BOLD中的激活相似，在这些记录位点中，不同的刺激引起与成像实验相同的相对激活。使用人工刺激，大胆和LFP的比较在很大程度上取决于所使用的频率范围。用复杂或自然的刺激刺激可降低这种频率依赖性，并产生LFP和粗体的良好匹配。通常，这场比赛在20至50 Hz之间最好。高频活动的度量在质上不同：模拟-MUA的响应与LFP的响应相匹配；尖峰活动与粗体信号的一致性低。在用自然刺激刺激时，大胆和尖峰活动的这种解离是最突出的。