HILBERT PHASE MICROSCOPY FOR INVESTIGATION OF RAPID DYNAMICS IN BIOLOGICAL SYST

用于研究生物系统快速动力学的希尔伯特相显微镜

• 批准号: 7600895
• 负责人: Gabriela K Popescu
• 金额: $ 3.52万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600895
• 关键词: Biological; Cells; Computer Retrieval of Information on Scientific Projects Database; Erythrocytes; Funding; Grant; Image; Institution; Investigation; Measurement; Measures; Microscopy; Nature; Optics; Phase; Process; Research; Research Personnel; Resolution; Resources; Source; Structure; System; Techniques; United States National Institutes of Health; Water; millisecond; novel; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We developed Hilbert phase microscopy (HPM) as a novel optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. The potential of this technique for studying biological systems was demonstrated with measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale was exemplified with measurements on evaporating micron-size water droplets.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们开发了希尔伯特相位显微镜（HPM）作为一种新颖的光学技术，用于测量与光学透明物体相关的高横向分辨率定量相位图像。由于其单次性质，HPM 适合研究快速现象 发生在生物细胞等透明结构中。通过对红细胞的测量证明了该技术研究生物系统的潜力，同时其在毫秒尺度上量化动态过程的能力也得到了证明。 以微米级水滴蒸发的测量为例。