CORE--AUDITORY PHYSIOLOGY

核心--听觉生理学

• 批准号: 7662401
• 负责人: David Francis Dolan
• 金额: $ 15.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7662401
• 关键词: Address; Animal Testing; Animals; Auditory; Auditory Brainstem Responses; Auditory Physiology; Condition; Data Correlations; Future; Graph; Histology; Human Resources; Individual; Journals; Measurement; Measures; Methods; Mus; Noise; Operative Surgical Procedures; Physiological; Physiology; Procedures; Publications; Quality Control; Research; Research Personnel; Schedule; Services; Standards of Weights and Measures; Stria Vascularis; Techniques; Work; data management

The Physiology Core will provide integrated services to the researchers of the individual projects. The Core personnel will work to coordinate physiological testing of animals with each individual project directors. The auditory brainstem response will be the primary method to evaluate auditory sensitivity across all projects. The endocochlear potential will be measured to address the status of stria vascularis in young and old mice. The Physiology Core will also coordinate noise exposures of animals with respect to each investigator's needs for exposures that will produce either temporary (ITS) or permanent (PTS) threshold shifts to meet the needs of the projects. The Physiology Core will provide all of the standard materials and services to accomplish the physiological measurements. The results obtained from the procedures described in this core will be analyzed and coordinated for statistical significance with the Data Management team and they will serve as consultants to discuss interpretation of data and correlation with other results. The Core will analyze and prepare graphs for presentation at scientific forums and publication in scientific journals. To further promote efficient and successful Core operation, frequent meetings will be used to discuss progress in research, emerging techniques and assist in future directions. Procedures are in place for scheduling and prioritization of services and quality control. The Histology Core and Physiology Core will work closely together to coordinate physiological and morphological characterization of animals under experimental conditions.

生理核心将为各个项目的研究人员提供综合服务。核心人员将致力于协调动物的生理测试与每个项目主管。听觉脑干响应将是评估所有项目中听觉敏感性的主要方法。将测量内切的电位，以解决年轻小鼠和老鼠中血管血管的状态。生理核心还将协调动物的噪声暴露于每个研究者的暴露需求，以产生临时（ITS）或永久（PTS）阈值转移以满足需求 项目。生理核心将提供所有标准材料和服务以完成生理测量。从本核心中描述的程序中获得的结果将进行分析和协调，以与数据管理团队的统计意义，并将作为顾问讨论对数据的解释以及与其他结果相关的解释。核心将在科学论坛和科学期刊上的科学论坛和出版物上进行分析和准备图表。为了进一步促进高效且成功的核心运作，将使用频繁的会议来讨论研究进展， 新兴技术并协助未来的方向。可以安排和优先级服务和质量控制的程序。组织学核心和生理核心将在实验条件下紧密合作，以协调动物的生理和形态特征。