Visceral Adiposity and Mortality in Japanese Americans

日裔美国人的内脏肥胖和死亡率

• 批准号: 7587453
• 负责人: MARGUERITE J MCNEELY
• 金额: $ 12.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7587453
• 关键词: Abdomen; Accounting; Age; Area; Asian Americans; Blood Pressure; Blood Tests; Body fat; Body mass index; Cardiovascular Diseases; Cause of Death; Cessation of life; Cholesterol; Clinical; Communities; Data; Death Certificates; Diabetes Mellitus; Diagnostic; Diet; Dyslipidemias; Enrollment; Family history of; Fasting; Fatty acid glycerol esters; Glucose; Goals; Health; Height; High Density Lipoprotein Cholesterol; Hip region structure; Hypertension; Insulin; Insulin Resistance; Intake; Intra-abdominal; Japan; Japanese American; Japanese Population; Knowledge; LDL Cholesterol Lipoproteins; Lead; Life; Life Style; Lipids; Longitudinal Studies; Measures; Medical History; Metabolic; Metabolic syndrome; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; OGTT; Obesity; Overweight; Pharmaceutical Preparations; Physical activity; Population; Prospective Studies; Public Health; Research; Risk; Smoking; Triglycerides; Visceral; Visit; Weight; Woman; X-Ray Computed Tomography; abdominal fat; base; clinically significant; diabetes risk; follow-up; glucose tolerance; high risk; improved; indexing; longitudinal database; men; mortality; public health relevance; saturated fat; sex; Abdomen; Accounting; Age; Area; Asian Americans; Blood Pressure; Blood Tests; Body fat; Body mass index; Cardiovascular Diseases; Cause of Death; Cessation of life; Cholesterol; Clinical; Communities; Data; Death Certificates; Diabetes Mellitus; Diagnostic; Diet; Dyslipidemias; Enrollment; Family history of; Fasting; Fatty acid glycerol esters; Glucose; Goals; Health; Height; High Density Lipoprotein Cholesterol; Hip region structure; Hypertension; Insulin; Insulin Resistance; Intake; Intra-abdominal; Japan; Japanese American; Japanese Population; Knowledge; LDL Cholesterol Lipoproteins; Lead; Life; Life Style; Lipids; Longitudinal Studies; Measures; Medical History; Metabolic; Metabolic syndrome; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; OGTT; Obesity; Overweight; Pharmaceutical Preparations; Physical activity; Population; Prospective Studies; Public Health; Research; Risk; Smoking; Triglycerides; Visceral; Visit; Weight; Woman; X-Ray Computed Tomography; abdominal fat; base; clinically significant; diabetes risk; follow-up; glucose tolerance; high risk; improved; indexing; longitudinal database; men; mortality; public health relevance; saturated fat; sex

DESCRIPTION (provided by applicant): The Japanese American Community Diabetes Study (JACDS) began in 1983 to describe the metabolic effects of westernization that may contribute to the higher risk for type 2 diabetes observed in Japanese Americans compared with native Japanese and US non-Hispanic whites. This prospective study enrolled a total of 735 men and women of 100% Japanese ancestry. Study visits occurred at baseline, 2.5 years, 5-6 years and 10- 11 years. Complete data for key variables is available for 733 subjects for 1 visit, and 70% of subjects have complete data for 3 visits. At each visit information about medical history, medication use, family history, diet, and physical activity was obtained, and weight, height, blood pressure, fasting blood tests (insulin, glucose and lipids), and visceral (intra-abdominal) fat area by computed tomography were measured. A 75-g oral glucose tolerance test was also performed at each visit. The overall aim of the proposed research is to use this rich longitudinal database to improve knowledge about the clinical significance of excess visceral fat (visceral adiposity). Our specific aim is to determine the associations between visceral adiposity, cardiovascular disease (CVD) mortality and all-cause mortality after accounting for differences in age, sex, smoking, body mass index, diet and physical activity. Mortality and cause of death from death certificates will be ascertained through December 31, 2005 by searching the National Death Index. We project that during the average follow-up period of 18 years there will be 111 deaths from CVD and 250 deaths from all causes among the 733 subjects with complete data for 1 visit. The results of this study will lead to a clearer understanding of the clinical impact of visceral adiposity on cardiovascular disease mortality and all-cause mortality after accounting for commonly used measures of obesity, such as body mass index. PUBLIC HEALTH RELEVANCE: This project is relevant to the public health because it will determine whether excess body fat inside the abdomen (visceral fat) contributes to the risk of death. We will also see whether the risk of death is higher in people who have more visceral fat even after accounting for obesity based on height and weight, diet and physical activity. This study also will improve understanding of the health risks for Asian Americans.

描述（由申请人提供）：日裔美国人社区糖尿病研究（JACDS）始于1983年，以描述西方化的代谢作用，这可能导致日裔美国人与日本本地和非日本人和非西班牙裔白人相比，日裔美国人观察到的2型糖尿病风险更高。这项前瞻性研究总共招募了735名日本血统的男女。研究访问发生在基线，2。5年，5 - 6年零10至11年。密钥变量的完整数据可用于1次访问的733名受试者，并且有70％的受试者具有3次访问的完整数据。在每次有关病史，药物使用，家族病史，饮食和体育锻炼的信息中，都测量了体重，体重，高度，血压，空腹血液测试（胰岛素，葡萄糖和脂质）以及计算机断层扫描的内脏（腹腔内）脂肪面积。每次访问还进行了75克口服葡萄糖耐受性测试。拟议的研究的总体目的是使用这个丰富的纵向数据库来提高有关过量内脏脂肪（内脏肥胖）的临床意义的知识。我们的具体目的是确定内脏肥胖，心血管疾病（CVD）死亡率（CVD）死亡率和全因死亡率之间的关联。死亡证明的死亡率和死亡原因将在2005年12月31日搜索国家死亡指数，从而确定死亡证明。我们预计，在18年的平均随访期间，CVD死亡111例，在733名受试者中有250人死亡，其中有250人死亡，并有完整的数据访问。这项研究的结果将使对内脏肥胖对心血管疾病死亡率和全因死亡率的临床影响有更清晰的了解，并考虑了常用的肥胖症措施，例如体重指数。 公共卫生相关性：该项目与公共卫生有关，因为它将决定腹部（内脏脂肪）内部过量的体内脂肪是否有助于死亡的风险。我们还将看到即使根据身高和体重，饮食和体育锻炼来考虑肥胖后，患有更多内脏脂肪的人的死亡风险是否更高。这项研究还将提高对亚裔美国人健康风险的了解。