Einstein-Rockefeller-CUNY Center for AIDS Research

爱因斯坦-洛克菲勒-纽约市立大学艾滋病研究中心

基本信息

批准号：
9922220
负责人：
HARRIS GOLDSTEIN
金额：
$ 289.44万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9922220
关键词：
AIDS prevention AIDS/HIV problem Academia Acquired Immunodeficiency Syndrome Adherence Area Back Basic Science Behavioral Behavioral Research Behavioral Sciences Biological Markers Cells Centers for Disease Control and Prevention (U.S.)Cities Clinical Clinical Research Collaborations Communities Community Health Development Discipline Disease Progression Early Diagnosis Epidemic Epidemiology Financial Support Government HIV HIV Infections HIV Seronegativity HIV Seropositivity HIV diagnosis HIV therapy HIV-1 Health Services Accessibility Health system Immunologic Adjuvants Improve Access Incidence Individual Infection Infrastructure Institution Interdisciplinary Study Interleukin-15 Leadership Link Medicine Mentors Methods Mission Modality New York New York City Outcome Outcomes Research Patients Persons Population Prevention Prevention strategy Preventive Process Prophylactic treatment Public Health Public Health Schools Reporting Research Research Personnel Resource Sharing Resources Science Services Strategic Planning Structure Technology Testing Translating Translational Research Treatment outcome United States United States National Institutes of Health Universities Vaginal Ring Viral antiretroviral therapy base bench to bedside career college community partnership design disease transmission epidemiology study forging health disparity high risk high risk population implementation research implementation science implementation strategy improved improved outcome innovation multidisciplinary neutralizing antibody next generation novel novel therapeutics patient population population health pre-clinical research prevent programs recruit research study skills social disparities synergism topical antiretroviral transmission process working group

项目摘要

PROJECT SUMMARY As the AIDS research community and public health systems locally, nationally and globally focus efforts on preventing HIV transmission and ending the epidemic, it is critical to integrate our efforts across institutions and disciplines, sharing resources among many researchers to achieve the greatest gain in scientific understanding. In the current absence of a CFAR in New York, an epicenter of HIV infection, our strategic planning process made clear that the greatest contribution of a New York City-based CFAR would be achieved by reaching out to other institutions. Thus, the Einstein/Rockefeller/CUNY (ERC)-CFAR has created a highly synergistic new partnership of non-overlapping complementary resources, linking a strong basic and clinical research institution (Einstein)`with a large patient base, a globally pre-eminent basic science institution (Rockefeller), and a strong public health/implementation science institution (CUNY) to catalyze research to prevent HIV and end the epidemic. We are structured to collaborate extensively across disciplines and institutions to drive a trans-institutional, interdisciplinary, and coordinated research agenda by ERC-CFAR investigators focused on “bench to bedside to community and back to the bench” research, and translating science into reality by assessing implementation of strategies and treatments shown to be efficacious in clinical and bench research. The ERC-CFAR will stimulate, coordinate, and support an integrated multidisciplinary research agenda to achieve our mission, to arrest the AIDS epidemic, through improving utilization of current treatments and developing new therapies, such as potent broadly neutralizing antibodies, for prevention, reducing the incidence of new infections; treatment, improving treatment outcomes among infected individuals; and eradication of HIV reservoirs. The ERC-CFAR will develop new research aimed at ending the epidemic by implementing five Specific Aims: 1) To empower a proactive, inclusive, and integrated program leadership approach to drive a trans-institutional, interdisciplinary, and coordinated research agenda by ERC-CFAR investigators focused on “bench to bedside to community and back to the bench” research to reduce HIV incidence, improve access to treatment, promote adherence, improve outcomes and eradicate HIV reservoirs to arrest the AIDS epidemic; 2) To utilize three Scientific Cores to support and advance the basic, clinical, behavioral, epidemiological, translational, and implementation research of the ERC-CFAR investigators; 3) To provide the intellectual, technical, and financial support to advance the careers of the next generation of young, innovative, and interdisciplinary HIV/AIDS investigators, while recruiting established investigators into HIV/AIDS research and forging new collaborations across institutions; 4) To build an innovative community partnership with representatives from government, community, and academia, to participate in collaborative studies to optimize HIV diagnosis, treatment, and prevention outcomes. 5) Identify pioneering scientific initiatives aligned with those identified by the Office of AIDS Research (OAR) Trans-NIH Strategic Plan for HIV- related research and actuate them by assembling interdisciplinary research/community ERC-CFAR teams and creative collaborations locally with other NYC HIV investigators and nationally with other CFARs.

项目概要随着艾滋病研究界和公共卫生系统在地方、国家和全球范围内集中努力在预防艾滋病毒传播和结束这一流行病方面，整合我们各机构的努力至关重要和学科，在许多研究人员之间共享资源，以实现科学的最大收获由于纽约是艾滋病毒感染中心，目前缺乏 CFAR，因此我们的战略是：规划过程明确表明，总部位于纽约市的恒虚警将实现最大贡献通过与其他机构联系，爱因斯坦/洛克菲勒/纽约市立大学 (ERC)-CFAR 创造了一个高度资源不重叠互补的协同新伙伴关系，链接强大的基础和临床研究机构（爱因斯坦）`拥有庞大的患者基础，全球卓越的基础科学研究机构（洛克菲勒）和强大的公共卫生/实施科学研究机构（纽约市立大学）来促进研究我们的结构是跨学科和跨领域合作。机构通过 ERC-CFAR 推动跨机构、跨学科和协调的研究议程研究人员专注于“从工作台到床边到社区再回到工作台”的研究，并将通过评估临床有效的实施策略和治疗方法，将科学变为现实 ERC-CFAR 将促进、协调和支持综合的多学科研究。研究议程，以实现我们的使命，通过提高现有资源的利用率来遏制艾滋病的流行治疗和开发新疗法，例如用于预防的有效广泛中和抗体，减少新感染的发生率；治疗，改善感染者的治疗结果； ERC-CFAR 将开展新的研究，旨在通过以下方式结束艾滋病毒流行。实施五个具体目标： 1) 增强积极主动、包容和综合的计划领导力 ERC-CFAR 推动跨机构、跨学科和协调的研究议程的方法研究人员专注于“从工作台到床边到社区再回到工作台”的研究，以减少艾滋病毒发病率、改善获得治疗的机会、促进依从性、改善结果并根除艾滋病毒储存库遏制艾滋病流行；2）利用三个科学核心支持和推进基础、临床、 ERC-CFAR 调查人员的行为、流行病学、转化和实施研究；3) 提供智力、技术和财政支持，以促进下一代年轻人的职业发展，创新的、跨学科的艾滋病毒/艾滋病调查员，同时招募成熟的调查员艾滋病毒/艾滋病研究和跨机构建立新的合作；4) 建立创新社区；与政府、社区和学术界的代表建立伙伴关系，参与合作优化艾滋病毒诊断、治疗和预防结果的研究 5) 确定开创性的科学成果。与艾滋病研究办公室 (OAR) 跨 NIH 艾滋病毒战略计划所确定的举措相一致相关研究并通过组建跨学科研究/社区 ERC-CFAR 团队来推动它们与纽约市其他艾滋病毒调查人员在当地以及在全国范围内与其他 CFAR 进行创造性合作。