CORE--NEUROPATHOLOGY

核心--神经病理学

• 批准号: 7459835
• 负责人: JULIE A. SCHNEIDER
• 金额: $ 46.04万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7459835
• 关键词: Aging; Alzheimer' s Disease; Arts; Autopsy; Biological; Blood; Brain; Cerebral Infarction; Cerebrospinal Fluid; Clinical; Cognitive; Collaborations; Collection; Country; DNA; Data; Dementia; Diagnosis; Diagnostic; Elderly; Funding; Goals; Journals; Lewy Body Disease; Link; Lymphocyte; Manuscripts; Methods; Microscopic; Neurobiology; Pathologic; Peer Review; Preservation Technique; Procedures; Process; Publications; Religion and Spirituality; Research; Research Personnel; Resources; Risk Factors; Specimen; Standards of Weights and Measures; System; Tissues; Work; antibody-dependent cell cytotoxicity; brain tissue; data management; indexing; mild neurocognitive impairment; minority subjects; motor impairment; neuropathology; research study

The major goal of the Neuropathology core of the Rush ADCC is to facilitate research on Alzheimer's disease and other dementias by providing to investigators a resource of well-preserved brain tissue, biological specimens, and neuropathologic data and diagnoses, from clinically well-characterized older subjects. Over the past years, the Core has supported an array of different studies including clinical-pathologic studies, studies of mild cognitive impairment and studies linking risk factors to the neuropathology and neurobiology underlying cognitive and motor impairment with aging. In addition the core has distributed tissue to externally-funded investigators at Rush, at other Alzheimer's disease centers, and other researchers across the country, and has facilitated the publication of numerous manuscripts in peer-reviewed journals. The core will continue to facilitate these studies and publications and with recruitment in both the Religious Orders Study Core and Clinical Core further extend these efforts to include minority subjects and subjects with atypical dementias. The Neuropathology Core plans to continue to practice optimal autopsy and collection procedures to obtain ante-mortem and post-mortem specimens and continue to use the uniform, standard and flexible techniques for preservation, processing and storage that allow for diverse research studies. The Core will continue to use state of the art diagnostic assessments on brain tissue to diagnose Alzheimer's disease, cerebral infarctions, Lewy body diseases, and will expand assessments for atypical dementias. Using modern data management systems the Neuropathology Core will index and store data and diagnoses making these readily available for external research. The Neuropathology Core will continue to distribute high quality specimens and neuropathologic data and diagnoses to externally funded investigators to facilitate and expand the scope of research on Alzheimer's disease and other dementias.

Rush ADCC神经病理学核心的主要目标是促进有关阿尔茨海默氏病的研究 和其他痴呆症通过向研究人员提供保存完好的脑组织的资源，生物学 来自临床表征良好的老年受试者的标本以及神经病理数据和诊断。超过 过去几年，核心支持了一系列不同的研究，包括临床病理学研究， 对危险因素与神经病理学和神经生物学联系的轻度认知障碍和研究的研究 衰老的基本认知和运动障碍。另外，核心具有分布的组织 拉什，其他阿尔茨海默氏病中心的外部资助的调查员和其他研究人员 国家，并促进了在同行评审期刊上发表众多手稿的出版。核心意愿 继续促进这些研究和出版物，并在两个宗教秩序研究中招募 核心和临床核心进一步扩展了这些努力，以包括少数群体和非典型受试者 痴呆症。神经病理学核心计划继续练习最佳尸检和收集程序 要获得事前验尸和验尸标本，并继续使用统一，标准和柔韧性 保存，加工和存储的技术，可以进行多种研究。核心意愿 继续使用对脑组织的最先进的诊断评估来诊断阿尔茨海默氏病， 脑梗塞，路易人的身体疾病，并将扩大非典型痴呆症的评估。使用现代 数据管理系统神经病理学核心将索引并存储数据，并诊断为这些 容易用于外部研究。神经病理学核心将继续分发高质量 标本和神经病理学数据，并向外部资助的研究人员进行诊断，以促进和扩展 关于阿尔茨海默氏病和其他痴呆症的研究范围。