LURDS-LIVING UNRELATED KIDNEY DONOR AND SIBLING FOLLOW-UP STUDY

LURDS-活体无关肾脏捐赠者和兄弟姐妹随访研究

• 批准号: 7608168
• 负责人: MATTHEW R. WEIR
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608168
• 关键词: Address; Affect; Blood Pressure; Cardiovascular Diseases; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Donor person; End stage renal failure; Enrollment; Follow-Up Studies; Funding; Genetic Predisposition to Disease; Grant; Growth; Homocysteine; Homocystine; Individual; Inflammation; Informed Consent; Institution; Kidney; Kidney Diseases; Kidney Transplantation; Knowledge; Life; Lipids; Metabolic syndrome; Numbers; Obesity; Observational Study; Patients; Plasma; Relative (related person); Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Siblings; Source; Staging; United States National Institutes of Health; age related; blood glucose regulation; cardiovascular disorder risk; improved; normal aging; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The growth in the use of living kidney donors makes it imperative to study possible adverse, long-term consequences of donation. This prospective cohort study will address whether donation increases the risk of developing end-stage kidney disease (ESRD) and/or increases the risk of cardiovascular disease (CVD). Pairs of living unrelated or distantly related kidney transplant donors and normal sibling controls will be enrolled. It has been argued that there is a gradual, long-term, compensatory GFR increase that offsets the normal age-associated decline in GFR, and thereby reduces the risk for ESRD. This proposal will make serial determinations of GFR during the first 3 years after donation to determine when the maximum post-donation GFR occurs. This will set the stage for long-term follow-up studies to determine how much the subsequent age-related declines in GFR increase the risk of ESRD. In addition, a number of observational studies report that patients with mild reductions in GFR are at increased risk for CVD. While CVD risk factors may cause Kidney damage, a growing amount of circumstantial evidence suggests that a mild reduction in GFR could adversely affect blood pressure, plasma lipids, glucose homeostasis, homocysteine, and even systemic inflammation. These effects may be most pronounced in the growing number of individuals who develop obesity and the metabolic syndrome. Living kidney donation makes it possible to study the effects of moderate reductions in GFR on CVD risk factors prospectively, using comparable siblings as normal controls. Using unrelated and distantly related donors will allow us to study the effects of donation per set, independent of genetic predisposition from having a close relative with kidney disease. Altogether, this study will provide useful information that will improve the informed consent for living kidney donors and enhance our knowledge of the role of the kidney, if any, in CVD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 活着的肾脏供体使用的增长使得必须研究捐赠的不利，长期后果。这项前瞻性队列研究将解决捐赠是否增加患终末期肾脏疾病（ESRD）的风险和/或增加心血管疾病（CVD）的风险。将招募成对的无关或遥远相关的肾脏移植供体和正常兄弟姐妹对照组。有人认为，存在逐渐，长期的代偿性GFR增加，抵消了与年龄相关的GFR下降，从而降低了ESRD的风险。该提案将在捐赠后的前三年对GFR进行序列确定，以确定最大捐赠后GFR何时发生。这将为长期随访研究奠定阶段，以确定随后与年龄相关的GFR下降的程度增加了ESRD的风险。此外，许多观察性研究报告称，GFR轻度降低的患者的CVD风险增加。尽管CVD危险因素可能会导致肾脏损害，但越来越多的间接证据表明，GFR的轻度降低可能会对血压，血浆脂质，葡萄糖稳态，同型半胱氨酸甚至全身性炎症产生不利影响。这些影响在越来越多的肥胖和代谢综合征的个体中最为明显。活肾捐赠使得使用可比的兄弟姐妹作为正常对照，可以前瞻性地研究GFR中等降低对CVD风险因素的影响。使用无关且遥远的供体将使我们能够研究每组捐赠的影响，而与遗传易感性无关，因为它们具有亲密的肾脏疾病。总的来说，这项研究将提供有用的信息，以改善活着的肾脏供体的知情同意，并增强我们对CVD肾脏（如果有的话）作用的了解。